INT57118

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Context Info
Confidence 0.56
First Reported 1994
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.65
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BGLAP) extracellular region (BGLAP) cell adhesion (BGLAP)
Golgi apparatus (BGLAP) structural molecule activity (BGLAP) cytoplasm (BGLAP)
Anatomy Link Frequency
osteoblasts 2
BGLAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 66 96.84 Very High Very High Very High
Rsd 1 84.00 Quite High
Inflammation 12 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
dexamethasone 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 66 96.84 Very High Very High Very High
Osteoporosis 34 95.28 Very High Very High Very High
Hypercalcemia 8 88.60 High High
Cleidocranial Dysplasia 1 84.76 Quite High
Complex Regional Pain Syndromes 1 84.00 Quite High
Disease 9 82.80 Quite High
Metabolic Bone Disease 2 82.12 Quite High
Chronic Renal Failure 2 62.12 Quite High
Calcification 1 31.32 Quite Low
INFLAMMATION 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The osteocalcin level measured with the two-site immunoradiometric assay specific for the intact molecule or with a conventional bovine RIA was rapidly decreased after incubation of serum at room temperature (-20 and -15%, respectively, after 3 h), whereas the total level of intact osteocalcin plus N-terminal midfragment was not changed.
Neg (not) Transcription (changed) of osteocalcin
1) Confidence 0.56 Published 1994 Journal J. Bone Miner. Res. Section Abstract Doc Link 8140939 Disease Relevance 0.78 Pain Relevance 0.08
BGLAP was described as a late marker of developing osteoblasts appearing with matrix mineralization [27] and was maximally expressed on day 21.
Transcription (described) of BGLAP in osteoblasts
2) Confidence 0.52 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.12 Pain Relevance 0
g/mL), or both together on human OA subchondral bone osteoblasts, in the presence or absence of 1,25(OH)2D3 (vitamin D3) (50 nM), was determined on the bone biomarkers alkaline phosphatase and osteocalcin, on the expression (mRNA) and production (enzyme-linked immunosorbent assay) of bone remodelling factors OPG and RANKL, and on the pro-resorptive activity of these cells.
Transcription (expression) of osteocalcin in osteoblasts associated with osteoarthritis
3) Confidence 0.23 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246236 Disease Relevance 0.65 Pain Relevance 0.29
Quantitative RT-PCR analysis showed lower levels of OC and ALP mRNA in T-MPCs compared with BM-MPCs (Figure 3b).
Transcription (levels) of OC
4) Confidence 0.22 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575631 Disease Relevance 0.10 Pain Relevance 0

General Comments

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