INT57136

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Context Info
Confidence 0.51
First Reported 1993
Last Reported 2004
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.60
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Alas1) nucleolus (Alas1) biosynthetic process (Alas1)
nucleus (Alas1) transferase activity, transferring acyl groups (Alas1) cytoplasm (Alas1)
Anatomy Link Frequency
CAR 1
body 1
Alas1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 10 100.00 Very High Very High Very High
Paracetamol 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 2 100.00 Very High Very High Very High
Porphyria 5 97.96 Very High Very High Very High
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No changes in the activity of ALA-S and in the hepatic and urinary porphyrin, ALA and PBG contents were observed.
Neg (No) Regulation (changes) of ALA-S associated with porphyria
1) Confidence 0.51 Published 1993 Journal Arzneimittelforschung Section Abstract Doc Link 8141818 Disease Relevance 0.27 Pain Relevance 0.42
Effects of different doses of clonidine (CAS 4205-90-7) (15, 150, or 300 micrograms/kg body weight) over a period of 3, 14, or 64 days on the activities of delta-aminolevulinic acid synthase (ALA-S) and the P450 dependent isoenzymes aminopyrine-N-demethylase (ADM), 7-ethoxycoumarin-O-deethylase (7-ECO-D), and 7-ethoxyresorufin-O-deethylase (7-ERO-D) as well as on the hepatic porphyrin and P450 content were studied in female rats.
Regulation (Effects) of ALA-S in body associated with body weight and clonidine
2) Confidence 0.38 Published 1993 Journal Arzneimittelforschung Section Abstract Doc Link 8141818 Disease Relevance 0.23 Pain Relevance 0.29
Although Alas1 is regulated transcriptionally by CAR-modulators having DR4 motifs in the promoter region as well as CYP2B1/2, BMAL1-NPAS2 and BMAL1-CLOCK heterodimers would be responsible for the daily physiological fluctuation in phase with Rev-erb?
Regulation (regulated) of Alas1 in CAR
3) Confidence 0.24 Published 2004 Journal Nucl Recept Section Body Doc Link PMC517509 Disease Relevance 0.10 Pain Relevance 0

General Comments

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