INT57138

Context Info Confidence 0.30 First Reported 1993 Last Reported 2010 Negated 2 Speculated 1 Reported most in Body Documents 13 Total Number 14 Disease Relevance 18.51 Pain Relevance 0.64

Anatomy Link Frequency coronary artery 1 heart 1 Hdlcl1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 46 100.00 Pain 17 88.28 Angina 10 82.64 Restless leg syndrome 1 72.32 alcohol 13 48.68 cytokine 2 14.60 Analgesic 6 5.00 withdrawal 6 5.00 ischemia 6 5.00 Bile 6 5.00

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 738 100.00 Diabetes Mellitus 165 100.00 INFLAMMATION 52 100.00 Hypertension 11 100.00 Hypertriglyceridemia 18 99.80 Disease 38 99.76 Cardiovascular Disease 60 99.40 Coronary Heart Disease 60 98.92 Coronary Artery Disease 70 98.64 Obesity 130 98.54

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High cholesterol (>5.2 mmol/L [213 mg/dL]) increased the risk of death from coronary heart disease, as would be expected; nevertheless, the excess risk associated with low HDL-cholesterol (?

HDL-cholesterol Binding (associated) of in heart associated with coronary heart disease, disorder of lipid metabolism and death

1) Confidence 0.30 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 1.25 Pain Relevance 0

In total, 8545 patients were included in the analysis; about one-third of patients had low HDL-cholesterol, and about one-fifth of patients had a potentially atherogenic combination of low HDL-cholesterol and elevated triglycerides (Table 1).

HDL-cholesterol Binding (combination) of associated with hypertriglyceridemia and disorder of lipid metabolism

2) Confidence 0.23 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 1.12 Pain Relevance 0

Importantly, the increased cardiovascular risk associated with low HDL-cholesterol was greater than that associated with elevated LDL-cholesterol, and persisted after adjustment for other lipid parameters and cardiovascular risk factors.

HDL-cholesterol Binding (associated) of associated with disorder of lipid metabolism

3) Confidence 0.23 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 0.91 Pain Relevance 0

Thus, the ARBITER 2 and ARBITER 3 trials demonstrate that increased HDL-cholesterol during treatment with Niaspan® and a statin was associated with clinically significant anti-atherogenic benefits in patients with coronary artery disease.

HDL-cholesterol Binding (associated) of in coronary artery associated with coronary artery disease and disorder of lipid metabolism

4) Confidence 0.23 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 1.06 Pain Relevance 0

Similar associations between low HDL-cholesterol and cardiovascular risk hold in other populations.

HDL-cholesterol Binding (associations) of associated with disorder of lipid metabolism

5) Confidence 0.23 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 1.02 Pain Relevance 0

This landmark study defined a significant association (p < 0.001) between low HDL-cholesterol and a range of cardiovascular endpoints in men and women during 4 years of follow-up.

HDL-cholesterol Binding (association) of associated with disorder of lipid metabolism

6) Confidence 0.22 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 0.90 Pain Relevance 0

No significant interactions were found between triglycerides and HDL-cholesterol.

HDL-cholesterol Neg (No) Binding (interactions) of associated with disorder of lipid metabolism

7) Confidence 0.22 Published 2010 Journal Eur J Epidemiol Section Body Doc Link PMC2991549 Disease Relevance 1.10 Pain Relevance 0

Female sex, low HDL-cholesterol, and absence of diabetes were associated with aortoiliac disease.

HDL-cholesterol Binding (associated) of associated with diabetes mellitus, disease and disorder of lipid metabolism

8) Confidence 0.10 Published 2003 Journal Vasc Med Section Abstract Doc Link 14518611 Disease Relevance 2.08 Pain Relevance 0.09

Low HDL-cholesterol and female sex were associated with disease severity.

HDL-cholesterol Binding (associated) of associated with disease and disorder of lipid metabolism

9) Confidence 0.10 Published 2003 Journal Vasc Med Section Abstract Doc Link 14518611 Disease Relevance 1.85 Pain Relevance 0.07

Thus, the aim of this study was to evaluate: 1) the nature and linearity of the association between different indicators of obesity and serum adiponectin levels, 2) whether or not anticipated inverse associations between adiponectin and HDL-cholesterol, triglycerides/apo B and CRP exist independent of BMI or waist circumference, 3) whether SHBG plays an independent role on concentrations of adiponectin in Turkish men and women in whom both atherogenic dyslipidemia and MetS prevail 11.

HDL-cholesterol Neg (not) Binding (associations) of associated with obesity and disorder of lipid metabolism

10) Confidence 0.02 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.03 Pain Relevance 0.09

HDL-cholesterol, apo B and CRP, parameters related to pro- and anti-inflammatory processes, showed different associations in the sexes.

HDL-cholesterol Binding (associations) of associated with inflammation and disorder of lipid metabolism

11) Confidence 0.02 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.06 Pain Relevance 0.05

In addition, its possible interaction with LDL- and HDL-cholesterol levels was investigated.

HDL-cholesterol Binding (interaction) of associated with disorder of lipid metabolism

12) Confidence 0.02 Published 2002 Journal Atherosclerosis Section Abstract Doc Link 12052486 Disease Relevance 1.65 Pain Relevance 0.14

Low HDL-cholesterol, total/HDL ratio, triglycerides and hypertension were associated with manifest CVD cross-sectionally.

HDL-cholesterol Binding (associated) of associated with cardiovascular disease, hypertension and disorder of lipid metabolism

13) Confidence 0.01 Published 1993 Journal Atherosclerosis Section Abstract Doc Link 8141850 Disease Relevance 2.23 Pain Relevance 0.14

Self-rated health showed a consistent association with serum HDL-cholesterol in the cross-sectional Oslo Health Study Objective: To examine the association between serum HDL-cholesterol concentration (HDL-C) and self rated health (SRH) in several age groups of men and women.

HDL-cholesterol Spec (examine) Binding (association) of associated with disorder of lipid metabolism

14) Confidence 0.01 Published 2007 Journal International Journal of Medical Sciences Section Title Doc Link PMC2096714 Disease Relevance 0.61 Pain Relevance 0.05

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