INT57145

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Context Info
Confidence 0.61
First Reported 1993
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.34
Pain Relevance 2.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRD1) cytoplasm (OPRD1) signal transducer activity (OPRD1)
Anatomy Link Frequency
brain 2
neuronal 1
OPRD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 13 100.00 Very High Very High Very High
nMDA receptor 10 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
Delta opioid receptors 2 100.00 Very High Very High Very High
Spinal cord 2 99.40 Very High Very High Very High
Opioid 12 98.40 Very High Very High Very High
mu opioid receptor 10 97.12 Very High Very High Very High
Neurotransmitter 1 89.48 High High
Central nervous system 5 85.92 High High
Cannabinoid receptor 9 84.00 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 3 82.52 Quite High
Hyperplasia 1 82.08 Quite High
Nervous System Malformation 1 74.48 Quite High
Teratocarcinoma 2 54.20 Quite High
Pituitary Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of the analyses also were compared with the density and distribution of delta-opioid receptors in the human brain in vitro.
Transcription (distribution) of delta-opioid in brain associated with delta opioid receptors
1) Confidence 0.61 Published 1999 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 10478647 Disease Relevance 0 Pain Relevance 0.35
Northern blot analysis revealed two transcripts for the N-methyl-D-aspartate receptor messenger RNA (4.2 and 4.4 kb) and two transcripts for delta opioid receptor messenger RNA (7.0 and 11.0 kb).
Transcription (transcripts) of delta opioid receptor associated with nmda receptor and opioid receptor
2) Confidence 0.43 Published 1997 Journal Neuroscience Section Abstract Doc Link 9219948 Disease Relevance 0.05 Pain Relevance 0.69
Northern blot analysis revealed two transcripts for the N-methyl-D-aspartate receptor messenger RNA (4.2 and 4.4 kb) and two transcripts for delta opioid receptor messenger RNA (7.0 and 11.0 kb).
Transcription (transcripts) of delta opioid receptor associated with nmda receptor and opioid receptor
3) Confidence 0.43 Published 1997 Journal Neuroscience Section Abstract Doc Link 9219948 Disease Relevance 0.05 Pain Relevance 0.67
These studies also found evidence for secretin, prostacyclin, opioid and alpha2-adrenergic receptors In support of this we found significantly high levels of mRNA for Ptgir1, Ptger1, Ptger3, Ptger4, Oprd1, Oprl1 and Adra2b.
Transcription (levels) of Oprd1 associated with opioid
4) Confidence 0.17 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0.08 Pain Relevance 0.14
Delta opioid receptor mRNA distribution in the brain: comparison to delta receptor binding and proenkephalin mRNA.
Transcription (distribution) of Delta opioid receptor mRNA in brain associated with enkephalin and opioid receptor
5) Confidence 0.03 Published 1993 Journal J. Chem. Neuroanat. Section Title Doc Link 8142072 Disease Relevance 0 Pain Relevance 0.55
Little mu or delta receptor mRNA expression was detected in any regions of neuronal proliferation prior to birth.
Transcription (detected) of delta receptor mRNA in neuronal
6) Confidence 0.00 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 9673792 Disease Relevance 0.16 Pain Relevance 0.59

General Comments

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