INT57157

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Context Info
Confidence 0.75
First Reported 1994
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 5
Total Number 8
Disease Relevance 3.97
Pain Relevance 4.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TDGF1) extracellular space (TDGF1) Golgi apparatus (TDGF1)
plasma membrane (TDGF1) nucleus (TDGF1) embryo development (TDGF1)
Anatomy Link Frequency
pancreas 1
dermis 1
posterior 1
skin 1
TEK 1
TDGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 144 100.00 Very High Very High Very High
Calcitonin gene-related peptide 14 100.00 Very High Very High Very High
chemokine 11 100.00 Very High Very High Very High
substance P 17 99.94 Very High Very High Very High
Limbic system 1 99.88 Very High Very High Very High
depression 36 99.76 Very High Very High Very High
Fibrositis 154 98.90 Very High Very High Very High
Neuropeptide 6 98.28 Very High Very High Very High
Pain 96 97.92 Very High Very High Very High
Enkephalin 6 97.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 32 99.76 Very High Very High Very High
Fibromyalgia 154 98.90 Very High Very High Very High
Hypersensitivity 13 98.68 Very High Very High Very High
Pain 94 97.92 Very High Very High Very High
Pancreatic Cancer 2 97.00 Very High Very High Very High
Contact Dermatitis 28 95.84 Very High Very High Very High
Ductal Carcinoma 3 95.36 Very High Very High Very High
Papillary Adenocarcinoma 1 94.04 High High
Adenoma 2 92.40 High High
Mucinous Cystadenoma 1 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of cripto gene product was examined immunohistochemically in 45 surgically resected pancreatic tumors, including 32 invasive ductal carcinomas, 4 intraductal papillary adenocarcinomas, 4 intraductal papillary adenomas, 2 mucinous cystadenomas, 2 islet cell tumors, and one solid and cystic tumor, and compared with that in 32 areas of accompanying chronic pancreatitis present in the cases of invasive ductal carcinomas and 5 non-tumorous areas of pancreas without pancreatitis.
Spec (examined) Gene_expression (expression) of cripto in pancreas associated with mucinous cystadenoma, islet cell adenoma, pancreatitis, adenoma, ductal carcinoma, papillary adenocarcinoma, cancer, pancreatic cancer and chronic pancreatitis
1) Confidence 0.75 Published 1994 Journal Jpn. J. Cancer Res. Section Abstract Doc Link 8144392 Disease Relevance 1.16 Pain Relevance 0.09
On the other hand, right branch shows overexpression areas with genes such as CASP 10, CD30-L, and CD-40-L (TNF family), ras-like small, FGF 3 and 5, TDGF1, ERK5, MIF, IFNGR2, MIG, IFN-alpha, beta, gamma, IL-3, -4, -9 and -13, IP-10, HPRT, DCC, TEK, netrin-2, cadherins 4, 8, 12 and 13 [33], MMP3, 8, 10, 12 and 13 (metalloproteinase), COL11A2, CCNG1, CDC-6, ATM, N-MYC, and p53.
Gene_expression (overexpression) of TDGF1 in TEK associated with metalloproteinase
2) Confidence 0.55 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.66 Pain Relevance 0.05
Using indirect immunohistochemistry, we analyzed the distribution of calretinin (CR), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), substance P (SP), neurokinin A (NKA), vasoactive intestinal peptide (VIP), nitric oxide synthase (NOS), tyrosine hydroxylase (TH), histamine, serotonin, enkephalin, and, enzyme histochemically, NADPH-diaphorase (NADPH-d).
Spec (analyzed) Gene_expression (distribution) of CR associated with neuropeptide, enkephalin, serotonin, substance p and calcitonin gene-related peptide
3) Confidence 0.23 Published 1997 Journal Acta Histochem. Section Abstract Doc Link 9381913 Disease Relevance 0 Pain Relevance 0.55
In the present study, we carried out histochemical and immunohistochemical procedures in the Pa of normal individuals to visualize the pattern of distribution of acetylcholinesterase (AChE), calbindin D-28k (CB), parvalbumin (PV), calretinin (CR), limbic system-associated membrane protein (LAMP), substance P (SP), and enkephalin (ENK).
Gene_expression (distribution) of CR associated with enkephalin, limbic system and substance p
4) Confidence 0.23 Published 2004 Journal Synapse Section Abstract Doc Link 14666515 Disease Relevance 0 Pain Relevance 0.39
In the dermis, SP-, CR-, VIP-, CGRP- and NKA-positive nerve fibers were detected.
Gene_expression (detected) of CR in dermis associated with calcitonin gene-related peptide and substance p
5) Confidence 0.18 Published 1997 Journal Acta Histochem. Section Abstract Doc Link 9381913 Disease Relevance 0 Pain Relevance 0.70
These data suggest that, regardless of whether an individual is an FM patient or a healthy control, individuals with higher levels of Glx and Glx/Cr also have enhanced sensitivity to induced pressure pain.



Gene_expression (levels) of Cr associated with pain, glutamate and fibrositis
6) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945024 Disease Relevance 0.72 Pain Relevance 0.95
In our study, a significant correlation was noted in the posterior gyrus between Glx levels and Glx/Cr ratios with depression (higher levels of glutamate correlated with higher depression scoring), pain measured with a sphygmomanometer (high levels of glutamate correlated with lower sphygmomanometer pressure, which means more proneness to experiencing pain), and global function assessed with FIQ (higher levels of glutamate levels correlated with worse global function).
Gene_expression (ratios) of Cr in posterior associated with pain, glutamate and depression
7) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945024 Disease Relevance 0.88 Pain Relevance 1.16
We studied the kinetics of the expression of CS-1 fibronectin, thymus and activation-regulated chemokine (CCL17/ TARC) and different chemokine receptors (CR) in skin biopsies from individuals suffering from back problems, with the antigen responsible of their contact dermatitis and an irrelevant antigen.


Gene_expression (expression) of CR in skin associated with chemokine and contact dermatitis
8) Confidence 0.02 Published 2002 Journal BMC Dermatol Section Abstract Doc Link PMC122084 Disease Relevance 0.55 Pain Relevance 0.14

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