INT57163

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Context Info
Confidence 0.75
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 2.45
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (AGFG1) transport (AGFG1) Golgi apparatus (AGFG1)
RNA binding (AGFG1) cytoplasmic membrane-bounded vesicle (AGFG1) nucleus (AGFG1)
Anatomy Link Frequency
Tooth 1
AGFG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 6 91.16 High High
agonist 214 89.60 High High
opiate 2 87.12 High High
Catecholamine 1 83.96 Quite High
metalloproteinase 1 74.52 Quite High
imagery 19 5.00 Very Low Very Low Very Low
Pain 11 5.00 Very Low Very Low Very Low
lancinating pain 6 5.00 Very Low Very Low Very Low
peripheral neuropathy 6 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pigment Disorder 12 99.04 Very High Very High Very High
Disease 150 98.42 Very High Very High Very High
Syndrome 128 97.92 Very High Very High Very High
Choroideremia 19 96.96 Very High Very High Very High
Charcot Marie Tooth Disease 54 92.48 High High
Mouth Disease 26 91.92 High High
Intellectual Impairment 25 89.24 High High
Death 9 84.08 Quite High
Apoptosis 8 83.36 Quite High
Hypercalcemia 25 80.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunocytochemistry and flow cytometry revealed that growth hormone and Rab proteins were coexpressed in the same cells.
Gene_expression (coexpressed) of Rab
1) Confidence 0.75 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 8144603 Disease Relevance 0 Pain Relevance 0.29
The REP brings the Rab to the RabGGT (Rab geranylgeranyl transferase) for the addition of—generally—two geranylgeranyl groups.
Gene_expression (transferase) of Rab
2) Confidence 0.14 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2413085 Disease Relevance 0 Pain Relevance 0
The REP brings the Rab to the RabGGT (Rab geranylgeranyl transferase) for the addition of—generally—two geranylgeranyl groups.
Gene_expression (transferase) of Rab
3) Confidence 0.14 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2413085 Disease Relevance 0 Pain Relevance 0
They first associate with a Rab escort protein (REP) and form a stable complex that is the substrate for the subsequent dual prenylation of C-terminal cysteine motifs via Rab geranylgeranyl transferase (RabGGT).
Gene_expression (transferase) of Rab
4) Confidence 0.14 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2413085 Disease Relevance 0.07 Pain Relevance 0
Although the clinical phenotype in these monogenic inherited diseases is highly variable and dependent on the type of tissue in which the defective Rab or its associated protein is expressed, frequent features are hypopigmentation (Griscelli syndrome), eye defects (Choroideremia, Warburg Micro syndrome and Martsolf syndrome), disturbed immune function (Griscelli syndrome and Charcot–Marie–Tooth disease) and neurological dysfunction (X-linked non-specific mental retardation, Charcot–Marie–Tooth disease, Warburg Micro syndrome and Martsolf syndrome).
Gene_expression (expressed) of Rab in Tooth associated with anesthesia, intellectual impairment, pigment disorder, choroideremia, syndrome, mouth disease, disease and charcot marie tooth disease
5) Confidence 0.12 Published 2008 Journal Eur J Pediatr Section Abstract Doc Link PMC2413085 Disease Relevance 1.75 Pain Relevance 0.09
The transfer of Rab proteins between acceptor and donor membranes is facilitated by the GDP dissociation inhibitor (GDI) (the GDI cycle is shown with red arrows).
Gene_expression (transfer) of Rab
6) Confidence 0.12 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2413085 Disease Relevance 0.05 Pain Relevance 0
Termination of Rab function is mediated through hydrolysis of the ?
Gene_expression (function) of Rab
7) Confidence 0.07 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0 Pain Relevance 0
In the absence of REP or RabGGT, Rab proteins remain in the cytosol in an inactive state.
Neg (absence) Gene_expression (absence) of Rab
8) Confidence 0.05 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2413085 Disease Relevance 0.06 Pain Relevance 0
For internalizations involving the co-expression of the various Rab proteins, HEK.hIP, HEK. hIP?
Gene_expression (expression) of Rab
9) Confidence 0.04 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.03
For internalizations involving the co-expression of the various Rab proteins, HEK.hIP, HEK. hIP?
Gene_expression (-) of Rab
10) Confidence 0.04 Published 2008 Journal Biochim Biophys Acta Section Body Doc Link PMC2680976 Disease Relevance 0 Pain Relevance 0.03
These are required for the post-translational prenylation (transfer of long-chain isoprenoid lipids) of proteins, including the GTP-binding proteins Ras, Rho, Rac, and Rab.
Gene_expression (transfer) of Rab
11) Confidence 0.02 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138713 Disease Relevance 0.53 Pain Relevance 0.04

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