INT57169

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Context Info
Confidence 0.72
First Reported 1994
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.39
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp2b1)
Anatomy Link Frequency
liver 1
kidney 1
Cyp2b1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 14 99.46 Very High Very High Very High
lidocaine 8 77.12 Quite High
anesthesia 1 70.12 Quite High
Inflammation 1 27.68 Quite Low
Analgesic 1 25.00 Low Low
Glutamate 5 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 5 97.56 Very High Very High Very High
Necrosis 1 86.84 High High
Cancer 60 86.48 High High
Glioma 18 77.92 Quite High
Severe Combined Immunodeficiency 3 76.08 Quite High
Pancreatic Cancer 1 75.84 Quite High
Injury 4 75.00 Quite High
Colon Cancer 16 68.32 Quite High
Hypoxia 3 51.52 Quite High
Suicidal Behaviour 7 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The administration of ACET down-regulated CYP1A2 and CYP2B1 expression in CD rats, while up-regulating them in NF rats.
Gene_expression (expression) of CYP2B1 associated with paracetamol
1) Confidence 0.72 Published 2009 Journal J Appl Toxicol Section Abstract Doc Link 18798224 Disease Relevance 0 Pain Relevance 0.58
These findings suggest that formation of MEGX in vivo is dependent on the levels of CYP2B1 or 3A2 in rat liver.
Gene_expression (levels) of CYP2B1 in liver
2) Confidence 0.58 Published 1997 Journal Drug Metab. Dispos. Section Abstract Doc Link 9172946 Disease Relevance 0 Pain Relevance 0.40
This pretreatment regimen caused marked increases in immunochemically determined levels of CYP2A1, CYP2B1, CYP2B2, CYP2C6, and CYP3A2, and in the activities of 2 alpha-, 2 beta-, 6 beta-, 7 alpha-, 16 alpha-, and 16 beta-hydroxylation and 17-oxidation of testosterone.
Spec (determined) Gene_expression (levels) of CYP2B1
3) Confidence 0.55 Published 1995 Journal Drug Metab. Dispos. Section Abstract Doc Link 8565792 Disease Relevance 0 Pain Relevance 0.07
The protein levels of CYP2B1 and 2E1 were significantly decreased by FFx; a decrease that was not prevented by GdCl3 treatment.
Gene_expression (levels) of CYP2B1
4) Confidence 0.52 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 14723344 Disease Relevance 0.44 Pain Relevance 0.07
The results are consistent with the hypothesis that CYP1A1 produces NAPQI preferentially because of closer proximity of the heme iron to the amide nitrogen, whereas CYP2B1 produces 3-OH-APAP preferentially because of closer proximity of the heme iron to the phenolic oxygen in this isoform.
Gene_expression (produces) of CYP2B1
5) Confidence 0.52 Published 1994 Journal J. Med. Chem. Section Abstract Doc Link 8145237 Disease Relevance 0 Pain Relevance 0.07
Feline kidney cells transfected with CYP2B1 were sensitized to IFO, and killed via necrotic rather than apoptotic mechanisms [91].
Gene_expression (transfected) of CYP2B1 in kidney associated with apoptosis
6) Confidence 0.16 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 0.94 Pain Relevance 0

General Comments

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