INT57178

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Context Info
Confidence 0.38
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.77
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (REG1A)
Anatomy Link Frequency
NAcc 1
REG1A (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 4 100.00 Very High Very High Very High
addiction 10 99.88 Very High Very High Very High
nMDA receptor 4 99.00 Very High Very High Very High
Nucleus accumbens 6 98.88 Very High Very High Very High
Opioid 3 88.48 High High
depression 58 87.20 High High
narcan 1 77.20 Quite High
agonist 2 69.84 Quite High
Action potential 8 65.44 Quite High
antagonist 1 41.40 Quite Low
Disease Link Frequency Relevance Heat
Opiate Addiction 2 99.88 Very High Very High Very High
Cancer 148 98.08 Very High Very High Very High
Depression 59 87.20 High High
Disease 33 79.36 Quite High
Li-fraumeni Syndrome 49 78.72 Quite High
Anxiety 12 50.68 Quite High
Sexually Transmitted Diseases 3 31.44 Quite Low
Cervical Cancer 11 5.00 Very Low Very Low Very Low
Shock 9 5.00 Very Low Very Low Very Low
Death 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The metropolitan physicians and surgeons who controlled the ICRF and the BECC considered education to be an unnecessary diversion from the main objectives of their organisations.
Regulation (controlled) of ICRF
1) Confidence 0.38 Published 2010 Journal Social History of Medicine Section Body Doc Link PMC2911267 Disease Relevance 1.00 Pain Relevance 0
To find out the cellular correlates of opiate addiction, the effects of three kinds of opiate peptides on membrane potential and postsynaptic potentials (PSPs) in a slice preparation of NAcc were studies by intracellular recording and current-clamp technique.
Regulation (effects) of PSPs in NAcc associated with nucleus accumbens, addiction and opiate
2) Confidence 0.13 Published 1993 Journal Sheng Li Xue Bao Section Abstract Doc Link 8146677 Disease Relevance 0.20 Pain Relevance 1.07
Regarding the absolute ┬ľnon-normalized- values, the average value of the PSPs during down states in vivo was 4.3┬▒1.2 mV (n?
Regulation (value) of PSPs
3) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1925142 Disease Relevance 0.07 Pain Relevance 0.04
APV did not block the effects of depolarization on the PSPs (N = 5; Table 2).
Regulation (effects) of PSPs
4) Confidence 0.03 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2832108 Disease Relevance 0.50 Pain Relevance 0.23

General Comments

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