INT57182

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Context Info
Confidence 0.55
First Reported 1994
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.37
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Dhfr) mRNA binding (Dhfr)
Dhfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
methotrexate 2 99.78 Very High Very High Very High
cINOD 1 61.04 Quite High
palliative 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 2 96.52 Very High Very High Very High
Cancer 9 75.00 Quite High
Carcinoma 1 72.88 Quite High
Breast Cancer 1 65.68 Quite High
Lung Cancer 2 25.00 Low Low
Disease 1 25.00 Low Low
Colon Cancer 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of dihydrofolate reductase.
Negative_regulation (Inhibition) of dihydrofolate reductase
1) Confidence 0.55 Published 1994 Journal Z. Naturforsch., C, J. Biosci. Section Title Doc Link 8148008 Disease Relevance 0.10 Pain Relevance 0.06
The primary site of action of the classic antifolate methotrexate is direct inhibition of dihydrofolate reductase, but it also inhibits TS indirectly by diminishing levels of the TS cosubstrate 5,10-methylenetetrahydrofolate.
Negative_regulation (inhibition) of dihydrofolate reductase associated with methotrexate
2) Confidence 0.08 Published 2002 Journal Expert Opin Investig Drugs Section Abstract Doc Link 12457437 Disease Relevance 0.28 Pain Relevance 0.09

General Comments

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