INT57187

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Context Info
Confidence 0.69
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 49
Total Number 51
Disease Relevance 27.59
Pain Relevance 11.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
astrocytes 8
retina 3
brain 3
spinal cord 3
photoreceptor 3
Gfap (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 252 100.00 Very High Very High Very High
glial activation 23 100.00 Very High Very High Very High
Morphine 11 99.70 Very High Very High Very High
allodynia 16 99.62 Very High Very High Very High
Sciatic nerve 14 99.44 Very High Very High Very High
Eae 14 99.14 Very High Very High Very High
Lasting pain 10 99.10 Very High Very High Very High
Hippocampus 131 98.32 Very High Very High Very High
Dorsal horn 42 98.24 Very High Very High Very High
cytokine 204 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 184 99.80 Very High Very High Very High
Cancer 154 99.68 Very High Very High Very High
Neuropathic Pain 130 99.62 Very High Very High Very High
Glaucoma 162 99.60 Very High Very High Very High
Injury 667 99.52 Very High Very High Very High
Hypertrophy 25 99.52 Very High Very High Very High
Stab Wounds 90 99.16 Very High Very High Very High
Brain Injury 133 99.12 Very High Very High Very High
Death 109 99.12 Very High Very High Very High
Pain 61 99.10 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This tumor-induced injury of sensory nerve fibers is accompanied by an increase in ongoing and movement-evoked pain behaviors, an upregulation of activating transcription factor 3 (ATF3) and galanin by sensory neurons that innervate the tumor-bearing femur, upregulation of glial fibrillary acidic protein (GFAP) and hypertrophy of satellite cells surrounding sensory neuron cell bodies within the ipsilateral dorsal root ganglia (DRG), and macrophage infiltration of the DRG ipsilateral to the tumor-bearing femur.
Positive_regulation (upregulation) of glial fibrillary acidic protein in sensory neurons associated with pain, hypertrophy, cancer and injury
1) Confidence 0.69 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15817267 Disease Relevance 1.73 Pain Relevance 0.79
Here, we found that chronic pain by sciatic nerve ligation caused a dramatic increase in glial fibrillary acidic protein (GFAP)-like immunoreactivity (IR), which is located in the dendritic astrocytes, with its expanding distribution in the cingulate cortex (CG) of mice.
Positive_regulation (increase) of GFAP in astrocytes associated with lasting pain and sciatic nerve
2) Confidence 0.67 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17316991 Disease Relevance 0.26 Pain Relevance 0.37
Injuries to the anterior segment and neuroretina following intracameral inoculation were evaluated pathologically via histological evaluation, molecularly via upregulation of glial fibrillary acidic protein (GFAP), and functionally via assessment of photoreceptor degeneration and electroretinogram (ERG) out to 24 days.
Positive_regulation (upregulation) of glial fibrillary acidic protein in photoreceptor associated with injury
3) Confidence 0.66 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2276183 Disease Relevance 0.49 Pain Relevance 0.11
Injuries to the anterior segment and neuroretina following intracameral inoculation were evaluated pathologically via histological evaluation, molecularly via upregulation of glial fibrillary acidic protein (GFAP), and functionally via assessment of photoreceptor degeneration and electroretinogram (ERG) out to 24 days.
Positive_regulation (upregulation) of GFAP in photoreceptor associated with injury
4) Confidence 0.66 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2276183 Disease Relevance 0.49 Pain Relevance 0.11
GFAP immunoreactivity was increased in Müller cells from the inner to the outer limiting membranes in retina from rats with elevated intraocular pressure [37].
Positive_regulation (increased) of GFAP in retina associated with ocular hypertension
5) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.99 Pain Relevance 0.16
Western blot analysis demonstrated significantly increased GFAP protein in retina and optic nerve of DBA/2J mice by 3 months of age (Figures 6E-H).


Positive_regulation (increased) of GFAP protein in optic nerve
6) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.38 Pain Relevance 0
Absence of IL-1R1 signaling leads to attenuated hypertrophy of astrocytes and delayed induction of GFAP (Fig. 1 and 2)
Positive_regulation (induction) of GFAP in astrocytes associated with hypertrophy
7) Confidence 0.58 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.26 Pain Relevance 0.10
Tg2576 mice display age-related neocortical and hippocampal amyloid deposits, which correlate with microglia activation, reactive astrocytes with increased GFAP, IL-1?
Positive_regulation (increased) of GFAP in astrocytes associated with amyloid plaque
8) Confidence 0.57 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC527877 Disease Relevance 1.46 Pain Relevance 0.53
The increase in Gfap is consistent with astrocyte response to neuronal cell damage [117].
Positive_regulation (increase) of Gfap in neuronal
9) Confidence 0.53 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2588578 Disease Relevance 0.69 Pain Relevance 0.07
In summary, this study on the effect of a penetrating brain injury in mice lacking IL-1R1 demonstrates that IL-1R1 deletion results in: 1) attenuated hypertrophy of astrocytes; 2) delayed cellular GFAP induction; 3) diminished induction of PAR1; 4) intact induction of extracellular matrix proteins and 5) intact induction of glutamate transporters, glutamine synthetase and S-100B.
Positive_regulation (induction) of GFAP in extracellular matrix associated with hypertrophy, glutamate and penetrating head injuries
10) Confidence 0.50 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.96 Pain Relevance 0.17
At 7 days after sciatic nerve ligation, the immunoreactivities (IRs) of the specific astrocyte marker glial fibrillary acidic protein (GFAP) and the specific microglial marker OX-42, but not the specific oligodendrocyte marker O4, were increased on the ipsilateral side of the spinal cord dorsal horn in nerve-ligated mice compared with that on the contralateral side.
Positive_regulation (increased) of GFAP in spinal cord dorsal horn associated with dorsal horn, sciatic nerve and spinal cord
11) Confidence 0.50 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16606373 Disease Relevance 0.25 Pain Relevance 0.66
Mechanical allodynia was significantly enhanced in the GFAP-TNF transgenic mice compared with the wild type mice.
Positive_regulation (enhanced) of GFAP associated with targeted disruption and allodynia
12) Confidence 0.49 Published 2000 Journal Neuroreport Section Abstract Doc Link 10718321 Disease Relevance 1.37 Pain Relevance 0.64
Increased GFAP labeling suggests the activation of glial cells overlaying the implant following the implantation surgery and this may be an inflammatory reaction to MEA.
Positive_regulation (Increased) of GFAP in glial cells associated with inflammation
13) Confidence 0.49 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802502 Disease Relevance 0.33 Pain Relevance 0.05
Formalin increased spinal cord c-Fos expression and glial fibrillary acidic protein immunostaining in both wild-type and transgenic mice.
Positive_regulation (increased) of glial fibrillary acidic protein in spinal cord associated with targeted disruption and spinal cord
14) Confidence 0.49 Published 2007 Journal Neuroreport Section Abstract Doc Link 17426605 Disease Relevance 0.62 Pain Relevance 0.34
Quantitative fluorescent measurements of intracellular free Ca2+ ([Ca2+]i) using Fura-2 as well as fluo-3 and computer-aided image analysis showed that 1 microM morphine significantly increased [Ca2+]i in flat, polyhedral, glial fibrillary acidic protein (GFAP) immunoreactive astrocytes at 2 and 6 min, and at 72 h.
Positive_regulation (increased) of glial fibrillary acidic protein in astrocytes associated with morphine
15) Confidence 0.46 Published 1993 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8149585 Disease Relevance 0 Pain Relevance 1.14
In contrast, the high Id2/Lpin1 expresser (the BXD38 strain) at 6 days after injury displayed GFAP labeling of Muller cells only at the peripheral retina and a delayed upregulation of GFAP in the central retina.
Positive_regulation (upregulation) of GFAP in retina associated with injury and sprains and strains
16) Confidence 0.44 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.49 Pain Relevance 0.06
In the neuroretina, a transient loss in ERG B-wave amplitudes was detected, but photoreceptor degeneration and GFAP upregulation were not.
Positive_regulation (upregulation) of GFAP in photoreceptor
17) Confidence 0.44 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2276183 Disease Relevance 0.40 Pain Relevance 0.13
This also correlated with neuroretinal trauma evidenced by a sustained loss in ERG function, increased GFAP levels indicative of active Muller as well as astrocyte cell gliosis, and significant photoreceptor cell degeneration.
Positive_regulation (increased) of GFAP in photoreceptor cell associated with injury and gliosis
18) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 1.09 Pain Relevance 0.15
At 7 days after sciatic nerve ligation, the immunoreactivities (IRs) of the specific astrocyte marker glial fibrillary acidic protein (GFAP) and the specific microglial marker OX-42, but not the specific oligodendrocyte marker O4, were increased on the ipsilateral side of the spinal cord dorsal horn in nerve-ligated mice compared with that on the contralateral side.
Positive_regulation (increased) of glial fibrillary acidic protein in spinal cord dorsal horn associated with dorsal horn, sciatic nerve and spinal cord
19) Confidence 0.44 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16606373 Disease Relevance 0.25 Pain Relevance 0.67
An increase in glial fibrillary acid protein (GFAP) immunoreactivity was observed in the contralateral SC at 7, 30, and 90 days after NMDA injection and in the ipsilateral SC at 7 days, while brain-derived neurotrophic factor (BDNF) expression was increased in the contralateral SC at 30 and 90 days.
Positive_regulation (increase) of GFAP in brain
20) Confidence 0.44 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2664844 Disease Relevance 0 Pain Relevance 0

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