INT57189

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Context Info
Confidence 0.56
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.35
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Chat) transferase activity, transferring acyl groups (Chat)
Anatomy Link Frequency
spinal 4
neurons 2
apoptotic cell 2
motoneurons 2
Chat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 2 100.00 Very High Very High Very High
Nerve growth factor 88 99.80 Very High Very High Very High
methadone 7 99.56 Very High Very High Very High
Hippocampus 14 90.16 High High
withdrawal 7 87.76 High High
Calcitonin gene-related peptide 1 82.88 Quite High
GABAergic 6 62.00 Quite High
Sciatica 6 25.00 Low Low
Intracerebroventricular 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 24 99.54 Very High Very High Very High
Apoptosis 22 99.32 Very High Very High Very High
Nervous System Injury 2 96.80 Very High Very High Very High
Injury 15 93.44 High High
Alzheimer's Dementia 4 75.00 Quite High
Aging 6 71.20 Quite High
Down Syndrome 2 63.56 Quite High
Disease 14 62.84 Quite High
Neurodegenerative Disease 14 32.12 Quite Low
Targeted Disruption 8 20.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, after avulsion, expression of APP and A/beta were downregulated in the spinal ventral horn of aged rats, and marked loss of spinal motor neurons and downregulated ChaT expression were observed.
Negative_regulation (downregulated) of Gene_expression (expression) of ChaT in spinal
1) Confidence 0.56 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12898540 Disease Relevance 0.46 Pain Relevance 0
RT97 expression was present in approximately 80% (+/-3.7) of surviving motoneurons at 7 dpo, and it was related to the regenerative response of motoneurons, as revealed by decreased ChAT expression and co-localization with GAP43.
Negative_regulation (decreased) of Gene_expression (expression) of ChAT in motoneurons
2) Confidence 0.53 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19331524 Disease Relevance 0 Pain Relevance 0.04
Thus, prenatal exposure to methadone appears to produce a delay in the expression of ChAT in striatal neurons.
Negative_regulation (delay) of Gene_expression (expression) of ChAT in neurons associated with methadone
3) Confidence 0.43 Published 1993 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8149590 Disease Relevance 0 Pain Relevance 0.60
In contrast, after avulsion, expression of APP and A/beta were downregulated in the spinal ventral horn of aged rats, and marked loss of spinal motor neurons and downregulated ChaT expression were observed.
Negative_regulation (downregulated) of Gene_expression (expression) of ChaT in spinal
4) Confidence 0.41 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12898540 Disease Relevance 0.46 Pain Relevance 0
However, there were always more cells labeled with p75, suggesting that some cholinergic cells had lost ChAT expression but continued expressing p75 (Figure 1C).
Negative_regulation (lost) of Gene_expression (expression) of ChAT
5) Confidence 0.25 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2826326 Disease Relevance 0.13 Pain Relevance 0.10
Our results establish that cholinergic cells do not respond to disconnection of their target, as induced by axotomy, with apoptotic cell-death, but rather with down-regulation of the neurotransmitter-synthesizing enzyme ChAT and NGF receptors.
Negative_regulation (regulation) of Gene_expression (synthesizing) of ChAT in apoptotic cell associated with neurotransmitter, nerve growth factor, apoptosis and death
6) Confidence 0.25 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2826326 Disease Relevance 0.30 Pain Relevance 0.33

General Comments

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