INT57192

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Context Info
Confidence 0.41
First Reported 1994
Last Reported 2011
Negated 4
Speculated 2
Reported most in Body
Documents 43
Total Number 46
Disease Relevance 17.48
Pain Relevance 24.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
synapses 4
dentate gyrus 3
hippocampus 2
postsynaptic membrane 1
PVN 1
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 1405 100.00 Very High Very High Very High
amygdala 823 100.00 Very High Very High Very High
Pain 181 100.00 Very High Very High Very High
c fibre 48 100.00 Very High Very High Very High
Glutamate 96 99.98 Very High Very High Very High
Periaqueductal grey 4 99.88 Very High Very High Very High
depression 567 99.84 Very High Very High Very High
nMDA receptor 330 99.78 Very High Very High Very High
Hippocampus 306 99.60 Very High Very High Very High
Sciatic nerve 12 99.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 221 100.00 Very High Very High Very High
Urological Neuroanatomy 24 99.88 Very High Very High Very High
Depression 565 99.84 Very High Very High Very High
Targeted Disruption 230 99.72 Very High Very High Very High
Anaerobic Bacterial Infections 32 99.60 Very High Very High Very High
Appetite Loss 45 99.14 Very High Very High Very High
Anxiety Disorder 198 98.40 Very High Very High Very High
Disease 73 98.22 Very High Very High Very High
Hypersensitivity 4 98.14 Very High Very High Very High
Cognitive Disorder 85 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study investigated the electrophysiological and behavioral consequences of the interactions between LTP and descending oxytocinergic antinociceptive mechanisms mediated by the hypothalamic paraventricular nucleus (PVN).
LTP Binding (interactions) of in PVN associated with long-term potentiation and antinociceptive
1) Confidence 0.41 Published 2009 Journal Pain Section Abstract Doc Link 19493620 Disease Relevance 0.50 Pain Relevance 0.88
To favor the detection of any putative change in extracellular glutamate associated with LTP, our experimental strategy included the following features. 1) Two separate series of experiments were carried out with animals under pentobarbital or urethan anesthesia; 2) changes in extracellular concentration of glutamate were monitored continuously by microdialysis coupled to enzyme amperometry; and 3) dialysate glutamate levels and changes in the slope of excitatory postsynaptic potential evoked by activation of the perforant path were recorded precisely at the same site.
LTP Binding (associated) of associated with anesthesia, glutamate and long-term potentiation
2) Confidence 0.31 Published 1999 Journal J. Neurophysiol. Section Abstract Doc Link 10200209 Disease Relevance 0 Pain Relevance 0.61
It should be noted that both L-NAME and the nNOS deficiency in knockout mice per se reduced the magnitude of LA-LTP.
LTP Binding (magnitude) of associated with targeted disruption, long-term potentiation and amygdala
3) Confidence 0.29 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0.17 Pain Relevance 1.46
In accordance with these investigations we directly show for the first time that the magnitude of LA-LTP is weaker in coronal than in horizontal slices.
LTP Binding (magnitude) of associated with long-term potentiation and amygdala
4) Confidence 0.29 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 0.92
These results suggest that metabotropic glutamate receptors play a role in facilitation of the formation of LTP in the dentate gyrus in vivo.
LTP Binding (formation) of in dentate gyrus associated with glutamate receptor and long-term potentiation
5) Confidence 0.28 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8149983 Disease Relevance 0.28 Pain Relevance 0.51
Intracerebroventricular injection of AP3 (50 nmol) prior to application of tetanic stimulation did not significantly affect LTP induced by 100-pulse, 100-Hz tetanus, but inhibited the formation of LTP by weaker tetanus (30 pulses at 60 Hz).
LTP Binding (formation) of associated with anaerobic bacterial infections, long-term potentiation and intracerebroventricular
6) Confidence 0.28 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8149983 Disease Relevance 0.29 Pain Relevance 0.53
The ERK activation is also suggested to contribute to the formation of LTD as well as LTP in the prefrontal cortex, in which the ERK activation is required for LTD mediated by the coactivation of dopamine receptors and metabotropic glutamate receptors [49].


LTP Binding (formation) of in prefrontal associated with glutamate receptor, dopamine receptor and long-term potentiation
7) Confidence 0.28 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0.25 Pain Relevance 0.82
Furthermore, we found that the MEK inhibitors did not affect the maintenance of cingulate LTP.
LTP Neg (not) Binding (maintenance) of associated with long-term potentiation
8) Confidence 0.28 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.32
The molecular mechanisms underlying the maintenance of LTP are not well understood.
LTP Binding (maintenance) of associated with long-term potentiation
9) Confidence 0.28 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.91
Even when the impermutable PPF-like facilitation was further enhanced (by about +120%), the enhancement was not correlated with either form of LTP, but exhibited the interaction of changes in the dorsal PPF, rather than in the heterotopic priming effect through the ventral projection.
LTP Binding (interaction) of in ventral associated with long-term potentiation
10) Confidence 0.27 Published 2006 Journal Brain Res. Section Abstract Doc Link 16859647 Disease Relevance 0 Pain Relevance 0.53
For example, reduced CA1 LTP is selectively associated with impaired contextual but not auditory fear memory in PKC?
CA1 LTP Binding (associated) of associated with anxiety disorder and long-term potentiation
11) Confidence 0.21 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 1.00 Pain Relevance 0.46
HFS at C-fibre intensity of sciatic nerve fibre afferents induces LTP of C-fibre, but not A?
LTP Binding (fibre) of in sciatic nerve associated with c fibre, long-term potentiation and sciatic nerve
12) Confidence 0.20 Published 2007 Journal Mol Pain Section Body Doc Link PMC1852298 Disease Relevance 0.30 Pain Relevance 1.31
Cannabinoids prevent the formation of LTP in the amygdala via activation of CB1 receptors.
LTP Neg (prevent) Binding (formation) of in amygdala
13) Confidence 0.20 Published 2005 Journal Schmerz Section Body Doc Link 16328555 Disease Relevance 0 Pain Relevance 0
LTP as a mechanism for open-eye potentiation
LTP Binding (potentiation) of in eye associated with long-term potentiation
14) Confidence 0.20 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674473 Disease Relevance 0.20 Pain Relevance 0.25
A study in GluR1-knockout mice showed that approximately 10% of the normal amount of GluR1 is sufficient for LTP (Mack et al. 2001).
LTP Binding (sufficient) of associated with targeted disruption and long-term potentiation
15) Confidence 0.19 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1892123 Disease Relevance 0.19 Pain Relevance 0.44
We also found increased LTP in CS-KO mice in both the hippocampal CA1 and dentate gyrus regions (Huang and Saido, unpublished data), even though no significant difference in LTP was detected in ?
LTP Binding (found) of in dentate gyrus associated with targeted disruption and long-term potentiation
16) Confidence 0.19 Published 2008 Journal Mol Brain Section Body Doc Link PMC2561015 Disease Relevance 0.66 Pain Relevance 0.16
A persistent late phase of LTP (L-LTP) in cortical and thalamic inputs to the LA, which is induced by repeated high frequency trains of presynaptic stimulation and is dependent on new protein synthesis, was found to be mediated by activation of ?
L-LTP Binding (inputs) of associated with long-term potentiation
17) Confidence 0.18 Published 2010 Journal Mol Brain Section Body Doc Link PMC2877027 Disease Relevance 0.40 Pain Relevance 0.52
A persistent late phase of LTP (L-LTP) in cortical and thalamic inputs to the LA, which is induced by repeated high frequency trains of presynaptic stimulation and is dependent on new protein synthesis, was found to be mediated by activation of ?
LTP Binding (inputs) of associated with long-term potentiation
18) Confidence 0.18 Published 2010 Journal Mol Brain Section Body Doc Link PMC2877027 Disease Relevance 0.40 Pain Relevance 0.52
Intact associative LTP at Cortico-LA synapses in early and late symptomatic Mecp2308/Y mutant mice
LTP Binding (associative) of in synapses associated with amygdala
19) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2896423 Disease Relevance 0 Pain Relevance 0.42
Next, we examined associative LTP at Cortico-LA synapses of adult Mecp2 KO mice.
LTP Spec (examined) Binding (associative) of in synapses associated with amygdala
20) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2896423 Disease Relevance 0.05 Pain Relevance 0.41

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