INT57217

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Context Info
Confidence 0.24
First Reported 1994
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.18
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF3) signal transduction (PENK) extracellular region (PENK)
nucleolus (ATF3) nucleus (ATF3)
ATF3 (Homo sapiens)
PENK (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 2 95.84 Very High Very High Very High
adenocard 2 75.00 Quite High
Enkephalin 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuroblastoma 2 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ATF-3 stimulates binding of Jun-D to the proenkephalin CRE-2 element and acts synergistically with Jun-D to induce proenkephalin gene expression.
ATF-3 Positive_regulation (induce) of Gene_expression (expression) of proenkephalin gene
1) Confidence 0.24 Published 1994 Journal Mol. Endocrinol. Section Abstract Doc Link 8152431 Disease Relevance 0.08 Pain Relevance 0.08
Cotransfection experiments indicate that activation of proenkephalin gene expression by ATF-3 is dependent upon both the catalytic subunit of the cAMP-dependent protein kinase and the CRE-2 element.
ATF-3 Positive_regulation (activation) of Gene_expression (expression) of proenkephalin gene
2) Confidence 0.24 Published 1994 Journal Mol. Endocrinol. Section Abstract Doc Link 8152431 Disease Relevance 0.10 Pain Relevance 0.09

General Comments

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