INT57222

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1994
Last Reported 2010
Negated 1
Speculated 5
Reported most in Body
Documents 22
Total Number 60
Disease Relevance 54.71
Pain Relevance 3.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF3) nucleolus (ATF3) nucleus (ATF3)
Anatomy Link Frequency
colon 19
subcutis 2
epithelial cells 1
SW620 1
SK-N-MC 1
ATF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 2 99.60 Very High Very High Very High
cINOD 143 99.12 Very High Very High Very High
antagonist 40 97.60 Very High Very High Very High
COX-2 inhibitor 79 92.84 High High
analgesia 11 83.44 Quite High
adenocard 2 75.00 Quite High
Thalamus 1 74.64 Quite High
Pain 110 69.20 Quite High
Analgesic 37 61.92 Quite High
Inflammation 25 60.80 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 356 100.00 Very High Very High Very High
Stress 267 100.00 Very High Very High Very High
Colon Cancer 1999 99.88 Very High Very High Very High
Cancer 3212 99.84 Very High Very High Very High
Metastasis 554 99.84 Very High Very High Very High
Targeted Disruption 117 99.78 Very High Very High Very High
Carcinoma 207 99.40 Very High Very High Very High
Colorectal Cancer 14 99.08 Very High Very High Very High
INFLAMMATION 124 98.88 Very High Very High Very High
Dna Damage 10 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, overexpression of antisense ATF3 was protumorigenic in vitro, however, not in vivo.
Gene_expression (overexpression) of ATF3
1) Confidence 0.78 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15897233 Disease Relevance 0.58 Pain Relevance 0.21
Overexpression of ATF3 in the sense orientation decreased focus formation in vitro and reduced the size of mouse tumor xenografts by 54% in vivo.
Gene_expression (Overexpression) of ATF3 associated with cancer
2) Confidence 0.78 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15897233 Disease Relevance 0.57 Pain Relevance 0.23
Furthermore, overexpression of ATF3 inhibited invasion to a similar degree as sulindac sulfide treatment, whereas antisense ATF3 increased invasion.
Gene_expression (overexpression) of ATF3
3) Confidence 0.78 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15897233 Disease Relevance 0.44 Pain Relevance 0.15
To ascertain the biological significance of ATF3, we overexpressed full-length ATF3 protein in the sense and antisense orientations.
Gene_expression (overexpressed) of ATF3
4) Confidence 0.78 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15897233 Disease Relevance 0.56 Pain Relevance 0.24
In this report, we show that ATF3 mRNA and protein expression are up-regulated in HCT-116 human colorectal cancer cells following treatment with NSAIDs, troglitazone, diallyl disulfide, and resveratrol.
Gene_expression (expression) of ATF3 associated with colorectal cancer and cinod
5) Confidence 0.78 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15897233 Disease Relevance 0.50 Pain Relevance 0.26
With microarray analysis, several genes relating to invasion and metastasis were identified by ATF3 overexpression and were confirmed by real-time reverse transcription-PCR, and several of these genes were modulated by sulindac sulfide, which inhibited invasion in these cells.
Gene_expression (overexpression) of ATF3 associated with metastasis
6) Confidence 0.78 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15897233 Disease Relevance 0.54 Pain Relevance 0.25
Because Hsp90 inhibition is known to affect a broad variety of signaling pathways, it is reasonable to conclude that inhibitors such as 17-DMAG overall lead to a net-gain in ATF3 expression.


Gene_expression (expression) of ATF3
7) Confidence 0.77 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.84 Pain Relevance 0
Indeed we found that blocking Hsp90 induces ATF3 protein expression in human gastric (TMK-1), colon (HT29, HCT116, SW620), and pancreatic (L3.6pl) cancer cell lines (Figure 1A and [8]).
Gene_expression (expression) of ATF3 in SW620 associated with cancer
8) Confidence 0.77 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.58 Pain Relevance 0
We conclude from these experiments that ATF3 expression in colon cancer cells is complexly controlled through the interaction of multiple molecular signaling pathways.
Gene_expression (expression) of ATF3 in colon associated with colon cancer
9) Confidence 0.77 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.73 Pain Relevance 0
Importantly, in vitro growth rates of Luc-shRNA and ATF3-shRNA transfected HCT116 cells were statistically not different (data not shown).
Gene_expression (transfected) of ATF3-shRNA
10) Confidence 0.77 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.21 Pain Relevance 0
Transgenic mice that overexpress ATF3 in basal epithelial cells develop epidermal hyperplasia, dysplastic lesions and oral squamous cell carcinoma [16].
Gene_expression (overexpress) of ATF3 in epithelial cells associated with targeted disruption, skin cancer and hyperplasia
11) Confidence 0.77 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.47 Pain Relevance 0
We next tested the effects of inhibited ATF3 expression on tumor metastasis in vivo in a model of hepatic tumor growth and in a model of peritoneal carcinomatosis.
Gene_expression (expression) of ATF3 associated with cancer, carcinoma and metastasis
12) Confidence 0.77 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.49 Pain Relevance 0
Thus, drug-induced overexpression of ATF3 may have beneficial effects in only a subset of colon cancer cells.
Gene_expression (overexpression) of ATF3 in colon associated with colon cancer
13) Confidence 0.77 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.49 Pain Relevance 0
We conclude that ATF3 is likely to be down-regulated in colon cancers, hence supporting the rationale of therapeutically inducing ATF3 expression in this cancer entity.


Gene_expression (expression) of ATF3 in colon associated with cancer and colon cancer
14) Confidence 0.77 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.54 Pain Relevance 0
For the analysis of ATF3 mRNA expression, snap frozen tissue samples of primary human colon carcinomas (n = 5) and corresponding non-neoplastic colon tissues (n = 5) were obtained from the anonymized tumor tissue bank of the Department of Pathology (University of Regensburg), as approved by clinical ethics committee [25].
Gene_expression (expression) of ATF3 mRNA in colon associated with cancer and colon cancer
15) Confidence 0.77 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.77 Pain Relevance 0
Tumors were harvested after 14 days of treatment to determine ATF3 protein expression (n = 3 per group).

(2) One-million ATF3-shRNA, or Luc-shRNA transfected HCT116 human colorectal cancer cells were injected into the subcutis of nude mice (n = 9-10 per group).

Spec (determine) Gene_expression (expression) of ATF3 in subcutis associated with cancer and colon cancer
16) Confidence 0.77 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.74 Pain Relevance 0
In colon cancer, the effects of ATF3 expression are particularly perplexing.
Gene_expression (expression) of ATF3 in colon associated with colon cancer
17) Confidence 0.77 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.56 Pain Relevance 0.11
In one respect, ATF3 was shown to be overexpressed in human colon cancer specimens and appears to promote tumor growth and migration in an experimental HT29 colon cancer model [18,19].
Gene_expression (overexpressed) of ATF3 in colon associated with cancer and colon cancer
18) Confidence 0.77 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.57 Pain Relevance 0.12
The effects of diminished ATF3 expression on tumor growth in vivo were first investigated in a subcutaneous tumor model using HCT116 cells.
Gene_expression (expression) of ATF3 associated with cancer
19) Confidence 0.77 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.10 Pain Relevance 0
Since studies report conflicting results regarding the role and expression of ATF3 in colorectal cancers, we determined ATF3 mRNA expression in human colon cancer specimens.
Gene_expression (expression) of ATF3 in colon associated with colon cancer
20) Confidence 0.77 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.68 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox