INT57232

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Context Info
Confidence 0.36
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 9.42
Pain Relevance 6.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleolus (Casp3) nucleus (Casp3) intracellular (Casp3)
Anatomy Link Frequency
NAc 2
cleavage 2
Brain 1
apoptotic cell 1
cerebellum 1
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 22 100.00 Very High Very High Very High
Nucleus accumbens 24 99.68 Very High Very High Very High
Hippocampus 60 99.52 Very High Very High Very High
antagonist 19 99.34 Very High Very High Very High
cocaine 3 99.22 Very High Very High Very High
Opioid 2 98.76 Very High Very High Very High
ischemia 162 98.68 Very High Very High Very High
Glutamate 616 97.96 Very High Very High Very High
agonist 10 95.24 Very High Very High Very High
Serotonin 6 94.64 High High
Disease Link Frequency Relevance Heat
Death 407 100.00 Very High Very High Very High
Apoptosis 573 99.68 Very High Very High Very High
Cerebral Hypoxia 2 99.56 Very High Very High Very High
Retina Disease 19 98.68 Very High Very High Very High
Stress 53 98.24 Very High Very High Very High
Ocular Hypertension 9 97.80 Very High Very High Very High
Myeloid Leukemia 3 95.84 Very High Very High Very High
Cerebellar Ataxia 37 94.80 High High
Cv Unclassified Under Development 102 94.56 High High
Cancer 52 93.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Brain tissues were sectioned at a thickness of 4 ┬Ám and cells showing caspase-3 and HSP70 activity were counted.
caspase-3 Binding (activity) of in Brain
1) Confidence 0.36 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872851 Disease Relevance 0.22 Pain Relevance 0
A pentanucleotide repeat expansion ATTCT is associated with SCA10 [142].
SCA1 Binding (associated) of
2) Confidence 0.36 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866461 Disease Relevance 1.66 Pain Relevance 0
This antibody recognizes the p18 subunit but not the inactive pro-caspase-3 [40].
pro-caspase-3 Binding (recognizes) of
3) Confidence 0.33 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0.63 Pain Relevance 0.26
NMDA (100 microM)-induced inhibition was counteracted by CPP, but not dizocilpine, and by the nitric oxide synthase inhibitor L-nitroarginine (1-100 microM).
CPP Binding (counteracted) of
4) Confidence 0.31 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9798925 Disease Relevance 0 Pain Relevance 0.17
Several studies have investigated the role of opioid antagonists on cocaine-induced conditioned place preference (CPP), but there is limited information about the interaction with amphetamines.
CPP Binding (interaction) of associated with antagonist, opioid and cocaine
5) Confidence 0.28 Published 2009 Journal Addict Biol Section Abstract Doc Link 19298318 Disease Relevance 0 Pain Relevance 0.47
Secondly, the nature of ligation of CCA and cell death and caspase-3 results (Figures 1, 2, 3) suggests that cerebellum would be less affected than hippocampus and would expect a shorter differentially expressed protein list for cerebellum.
caspase-3 Binding (ligation) of in cerebellum associated with hippocampus and death
6) Confidence 0.25 Published 2010 Journal Chin Med Section Body Doc Link PMC2984508 Disease Relevance 0.60 Pain Relevance 0.31
Caspase-3 is considered a key executioner in the apoptotic cell death cascade and shares numerous substrates with Ca2+-dependent protease calpain such as cytoskeletal protein ?
Caspase-3 Binding (executioner) of in apoptotic cell associated with apoptosis and death
7) Confidence 0.18 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1526740 Disease Relevance 1.22 Pain Relevance 0.30
-fodrin breakdown patterns produced by calpain or caspase-3, the effects of calpain and caspase inhibitors on glutamate-induced cleavage of ?
caspase-3 Binding (calpain) of in cleavage associated with glutamate
8) Confidence 0.18 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1526740 Disease Relevance 0.26 Pain Relevance 0.29
Our current findings indicate that estrogens prevent glutamate-induced cell death by reducing the upregulation and/or translocation of AIF from the mitochondria into the cytosol as well as by attenuating activity of calpain and caspase-3 in primary cortical cells and HT22 cells, with ?
caspase-3 Binding (activity) of associated with glutamate and death
9) Confidence 0.18 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1526740 Disease Relevance 0.69 Pain Relevance 0.23
Furthermore, intra-NAc infused RU38486 (10 microg per side) but not DMSO vehicle also prevented the formation of CPP.
CPP Binding (formation) of in NAc associated with nucleus accumbens
10) Confidence 0.17 Published 2006 Journal Hippocampus Section Abstract Doc Link 16897719 Disease Relevance 0 Pain Relevance 0.95
In contrast, systemic administration (5 mg/kg, s.c.) or intrahippocampal infusion (0, 0.1, 1.0, 10, 20 microg per side) of the GR antagonist RU38486 blocked or impaired the formation of CPP in a dose-dependent manner, respectively.
CPP Binding (formation) of associated with antagonist
11) Confidence 0.17 Published 2006 Journal Hippocampus Section Abstract Doc Link 16897719 Disease Relevance 0 Pain Relevance 0.95
It also links caspase-3 to the deleterious effect induced by the elevation of IOP.
caspase-3 Binding (links) of associated with ocular hypertension
12) Confidence 0.16 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.65 Pain Relevance 0.17
Here, we examined whether glucocorticoid receptors (GRs) of hippocampus and NAc influenced the formation of morphine CPP in Sprague Dawley rats.
CPP Binding (formation) of in NAc associated with nucleus accumbens, hippocampus and morphine
13) Confidence 0.15 Published 2006 Journal Hippocampus Section Abstract Doc Link 16897719 Disease Relevance 0 Pain Relevance 0.76
At 24 hours, caspase-3 activity remained significantly higher within the infarct core of the TNF?
caspase-3 Binding (activity) of
14) Confidence 0.15 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2583993 Disease Relevance 0.77 Pain Relevance 0
In previous studies, we have shown that cerebral hypoxia results in increased activity of caspase-9, the initiator caspase, and caspase-3, the executioner of programmed cell death.
caspase-3 Binding (activity) of associated with cerebral hypoxia and apoptosis
15) Confidence 0.09 Published 2007 Journal Neurochem. Res. Section Abstract Doc Link 17268855 Disease Relevance 0.55 Pain Relevance 0.24
Although mCPP is known to interact with 5-HT receptors, this drug is also reported to exhibit presynaptic actions that increase extraneuronal 5-HT in vitro.
mCPP Binding (interact) of
16) Confidence 0.08 Published 1993 Journal Neuropharmacology Section Abstract Doc Link 8152528 Disease Relevance 0 Pain Relevance 0.26
B binding activity, ERK and p-38-dependent cytochrome c release, and caspase-3 activation [22-24].
caspase-3 Binding (binding) of
17) Confidence 0.08 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.73 Pain Relevance 0
Caspase-3 assay
Caspase-3 Binding (assay) of
18) Confidence 0.08 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.35 Pain Relevance 0
However, we would need alternative methods of evaluating apoptotic index (eg TUNEL, etc) due to problems associated with Caspase-3 in any future study.
Caspase-3 Binding (associated) of associated with apoptosis
19) Confidence 0.06 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2669088 Disease Relevance 0.25 Pain Relevance 0.09
Here, we examined whether glucocorticoid receptors (GRs) of hippocampus and NAc influenced the formation of morphine CPP in Sprague Dawley rats.
CPP Binding (formation) of in hippocampus associated with nucleus accumbens, hippocampus and morphine
20) Confidence 0.05 Published 2006 Journal Hippocampus Section Abstract Doc Link 16897719 Disease Relevance 0 Pain Relevance 0.76

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