INT57252

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Context Info
Confidence 0.43
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 12.95
Pain Relevance 3.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PGR) enzyme binding (PGR) DNA binding (PGR)
cell-cell signaling (PGR) cytoplasm (PGR) signal transduction (PGR)
Anatomy Link Frequency
anterior 2
uterine cervix 2
uterine 2
plasma 1
arm 1
PGR (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 88 100.00 Very High Very High Very High
cINOD 3 98.86 Very High Very High Very High
withdrawal 14 98.84 Very High Very High Very High
abdominal pain 1 98.80 Very High Very High Very High
antagonist 53 98.48 Very High Very High Very High
endometriosis 286 98.40 Very High Very High Very High
Inflammation 118 97.40 Very High Very High Very High
Angina 2 93.88 High High
cytokine 68 93.28 High High
dexamethasone 7 90.40 High High
Disease Link Frequency Relevance Heat
Depression 93 100.00 Very High Very High Very High
Endometriosis 344 99.84 Very High Very High Very High
Cancer 262 99.76 Very High Very High Very High
Triple Negative Breast Cancer 2 99.38 Very High Very High Very High
Inflammatory Breast Neoplasms 117 99.24 Very High Very High Very High
Heart Rate Under Development 5 99.24 Very High Very High Very High
Bundle-branch Block 2 99.12 Very High Very High Very High
Abdominal Pain 1 98.80 Very High Very High Very High
Disease 140 98.72 Very High Very High Very High
INFLAMMATION 117 98.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After cessation of the intervention (March 2003) the PR had decreased significantly in Balbino, as compared to Pedro de Souza (PR?
Negative_regulation (decreased) of PR
1) Confidence 0.43 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2565488 Disease Relevance 0.30 Pain Relevance 0
Some nonsteroidal anti-inflammatory drugs (NSAIDs), which primarily act as cyclooxygenase inhibitors also inhibit LTB(4) 12-HD/PGR activity.
Negative_regulation (inhibit) of PGR associated with inflammation and cinod
2) Confidence 0.42 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15007077 Disease Relevance 0.10 Pain Relevance 0.20
Right bundle branch block with left anterior hemiblock and prolonged PR interval-trifascicular block.
Negative_regulation (block) of PR in anterior associated with bundle-branch block
3) Confidence 0.39 Published 1993 Journal Singapore Med J Section Title Doc Link 8153725 Disease Relevance 0.57 Pain Relevance 0.09
"Triple negativity" was defined as a lack of expression of ER, PgR, and HER2.
Negative_regulation (lack) of PgR
4) Confidence 0.33 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2972282 Disease Relevance 0.21 Pain Relevance 0
Studies from 1981 to 1990 have described the ER and PgR status of patient IBC samples and their relationship to prognosis [20].
Negative_regulation (described) of PgR associated with inflammatory breast neoplasms
5) Confidence 0.25 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.35 Pain Relevance 0.03
About 40% of tumor cells were positive for estrogen receptor (ER) (Figure 1H) and progesterone receptor (PgR), but negative for HER2, phenotypically corresponding to Luminal A type.
Negative_regulation (positive) of PgR associated with cancer
6) Confidence 0.25 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2936386 Disease Relevance 1.09 Pain Relevance 0.07
About 40% of tumor cells were positive for estrogen receptor (ER) (Figure 1H) and progesterone receptor (PgR), but negative for HER2, phenotypically corresponding to Luminal A type.
Negative_regulation (positive) of progesterone receptor associated with cancer
7) Confidence 0.25 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2936386 Disease Relevance 1.09 Pain Relevance 0.07
Studies of hormone-ligand binding assays and enzyme immunoassays showed a consistent reduction in the content of ER and PR in endometriotic implants [44-47].
Negative_regulation (reduction) of PR associated with endometriosis
8) Confidence 0.21 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2752458 Disease Relevance 0.93 Pain Relevance 0.18
There will also be great benefit in generating better mouse models of specific types of human breast cancer, ranging from triple negative breast cancer (oestrogen receptor negative, progesterone receptor negative and HER2 negative) to oestrogen receptor positive tumours.
Negative_regulation (negative) of progesterone receptor associated with cancer, triple negative breast cancer and breast cancer
9) Confidence 0.18 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397525 Disease Relevance 1.00 Pain Relevance 0
Recently, we have demonstrated that before parturition, diminished responsiveness of the cervix to P4 might be caused by a decrease in progesterone receptor (PR) levels and this may be the mechanism of functional P4 withdrawal in the uterine cervix at term [21].
Negative_regulation (decrease) of progesterone receptor in uterine cervix associated with withdrawal
10) Confidence 0.17 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305330 Disease Relevance 0.07 Pain Relevance 0.22
Recently, we have demonstrated that before parturition, diminished responsiveness of the cervix to P4 might be caused by a decrease in progesterone receptor (PR) levels and this may be the mechanism of functional P4 withdrawal in the uterine cervix at term [21].
Negative_regulation (decrease) of PR in uterine cervix associated with withdrawal
11) Confidence 0.17 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305330 Disease Relevance 0.07 Pain Relevance 0.22
Both before and during testosterone CLON lowered SBP, DBP and PR in HP to the same extent observed in NS.
Negative_regulation (lowered) of PR
12) Confidence 0.17 Published 1996 Journal J. Endocrinol. Invest. Section Abstract Doc Link 8905472 Disease Relevance 0.13 Pain Relevance 0.37
Of the 9 evaluable patients in the weekly arm, 1 patient achieved a PR and 7 patients achieved stable disease.
Negative_regulation (achieved) of PR in arm associated with disease
13) Confidence 0.11 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2579406 Disease Relevance 0.92 Pain Relevance 0
The suppression of progesterone receptors (PR) – effectively a functional withdrawal of progesterone – is also linked to the initiation of labor in humans.
Negative_regulation (suppression) of PR associated with withdrawal
14) Confidence 0.09 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2861440 Disease Relevance 0.07 Pain Relevance 0.29
Both pathways promote expression of the uterine milk proteins, but downregulation of the progesterone receptor is also required as this exerts an inhibitory influence [40].
Negative_regulation (downregulation) of progesterone receptor in uterine
15) Confidence 0.09 Published 2007 Journal Placenta Section Body Doc Link PMC1878510 Disease Relevance 0.14 Pain Relevance 0
In the late secretory phase, and related with a decrease of endometrial progesterone receptor and plasma progesterone concentration, cell death by apoptosis increases in the functional endometrial layer, and at the time of menstruation it becomes necrotic and hypoxic and is shed.
Negative_regulation (decrease) of progesterone receptor in plasma associated with hypoxia, apoptosis and death
16) Confidence 0.07 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1262771 Disease Relevance 0.82 Pain Relevance 0.11
One of the major concerns in studies on preterm labor, especially on uterine contractile activity is that practically none of the models is adequately sufficient and easy to use – mice uteri lack V1a vasopressin receptor [4], rats present with spontaneous uterine contractility [5] and labor in ginea pigs is characterized by the desensitization of the progesterone receptor [6].
Negative_regulation (desensitization) of progesterone receptor in uterine associated with pre-term labor
17) Confidence 0.05 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892063 Disease Relevance 0.29 Pain Relevance 0
This premature PR decrease was consistent with an early high progesterone level [79].
Negative_regulation (decrease) of PR
18) Confidence 0.05 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0 Pain Relevance 0
Such approaches may include aromatase inhibitors, progestins, and progesterone receptor modulators.
Negative_regulation (inhibitors) of progesterone receptor
19) Confidence 0.04 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 1.31 Pain Relevance 0.90
An electrocardiogram showed depression of the PR segment, moderate sinus tachycardia and diffuse ST segment elevation, which was concave upwards, was present in the anterior leads.
Negative_regulation (depression) of PR in anterior associated with heart rate under development and depression
20) Confidence 0.02 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2441635 Disease Relevance 1.85 Pain Relevance 0.28

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