INT57253

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 1993
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 24
Total Number 24
Disease Relevance 5.27
Pain Relevance 22.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
medulla 12
pons 4
nucleus accumbens 2
ileum 2
CPu 2
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 333 100.00 Very High Very High Very High
opioid receptor 251 100.00 Very High Very High Very High
Opioid 174 100.00 Very High Very High Very High
medulla 48 100.00 Very High Very High Very High
Enkephalin 20 100.00 Very High Very High Very High
agonist 19 99.76 Very High Very High Very High
Nucleus accumbens 12 99.68 Very High Very High Very High
narcan 208 99.60 Very High Very High Very High
cocaine 19 99.56 Very High Very High Very High
Immobilon 12 98.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 57 100.00 Very High Very High Very High
Neuroblastoma 1 100.00 Very High Very High Very High
Hyperalgesia 11 98.96 Very High Very High Very High
Respiratory Tract Infection 9 98.56 Very High Very High Very High
Neuropathic Pain 2 94.32 High High
Urological Neuroanatomy 1 83.04 Quite High
Helminth Infection 1 70.08 Quite High
Tics 1 62.20 Quite High
Cocaine Dependence 1 40.44 Quite Low
Opiate Addiction 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A second exposure to DAMGO (100 nM) following recovery of internalized muOR immunoreactivity at the cell surface induced a translocation of muOR immunoreactivity in the cytoplasm comparable to the one observed following the first exposure (46.89+/-3.11% versus 43.31+/-3.80%). muOR internalization was prevented by hyperosmolar sucrose, phenylarsine oxide or potassium depletion, which inhibit clathrin-mediated endocytosis. muOR recycling was prevented by pre-treatment with bafilomycin A1, an acidotropic agent that inhibits endosomal acidification, but not by the protein synthesis inhibitor, cycloheximide.
Negative_regulation (prevented) of muOR Binding (internalization) of
1) Confidence 0.43 Published 2003 Journal Neuroscience Section Abstract Doc Link 12763066 Disease Relevance 0 Pain Relevance 0.39
We now report that the binding of mu-opioid receptor ligand, [3H][D-Ala2,NHPhe4,Gly-ol]enkephalin to membrane preparations of the pons/medulla was reduced by half in heterozygous mu-opioid receptor knockout mice and eliminated in homozygous mu-opioid receptor knockout mice.
Negative_regulation (reduced) of mu-opioid receptor Binding (binding) of in medulla associated with targeted disruption, medulla, enkephalin and opioid receptor
2) Confidence 0.42 Published 1999 Journal Neuroscience Section Abstract Doc Link 10613510 Disease Relevance 0.42 Pain Relevance 1.18
We now report that the binding of mu-opioid receptor ligand, [3H][D-Ala2,NHPhe4,Gly-ol]enkephalin to membrane preparations of the pons/medulla was reduced by half in heterozygous mu-opioid receptor knockout mice and eliminated in homozygous mu-opioid receptor knockout mice.
Negative_regulation (eliminated) of mu-opioid receptor Binding (binding) of in medulla associated with targeted disruption, medulla, enkephalin and opioid receptor
3) Confidence 0.42 Published 1999 Journal Neuroscience Section Abstract Doc Link 10613510 Disease Relevance 0.43 Pain Relevance 1.22
We now report that the binding of mu-opioid receptor ligand, [3H][D-Ala2,NHPhe4,Gly-ol]enkephalin to membrane preparations of the pons/medulla was reduced by half in heterozygous mu-opioid receptor knockout mice and eliminated in homozygous mu-opioid receptor knockout mice.
Negative_regulation (reduced) of mu-opioid receptor Binding (binding) of in medulla associated with targeted disruption, medulla, enkephalin and opioid receptor
4) Confidence 0.42 Published 1999 Journal Neuroscience Section Abstract Doc Link 10613510 Disease Relevance 0.43 Pain Relevance 1.21
We now report that the binding of mu-opioid receptor ligand, [3H][D-Ala2,NHPhe4,Gly-ol]enkephalin to membrane preparations of the pons/medulla was reduced by half in heterozygous mu-opioid receptor knockout mice and eliminated in homozygous mu-opioid receptor knockout mice.
Negative_regulation (reduced) of mu-opioid receptor Binding (binding) of in medulla associated with targeted disruption, medulla, enkephalin and opioid receptor
5) Confidence 0.42 Published 1999 Journal Neuroscience Section Abstract Doc Link 10613510 Disease Relevance 0.44 Pain Relevance 1.26
In complimentary experiments we found that CXBK mice which have reduced mu-opioid receptor binding displayed no significant OIH after morphine treatment.
Negative_regulation (reduced) of mu-opioid receptor Binding (binding) of associated with hyperalgesia, opioid receptor and morphine
6) Confidence 0.37 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11165371 Disease Relevance 1.03 Pain Relevance 2.07
When bovine striatal membranes were incubated with any of the four dihydrocodeinones, binding to the mu receptor was inhibited in a concentration-dependent, wash-resistant manner.
Negative_regulation (inhibited) of mu receptor Binding (binding) of
7) Confidence 0.36 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087018 Disease Relevance 0 Pain Relevance 0.54
In conclusion, our results suggest that high-dose methadone maintenance does not alter the direct reinforcing effect of cocaine, but blocks spontaneous and cocaine-precipitated cocaine-seeking, possibly by preventing MOR alterations in the nucleus accumbens core induced by cocaine conditioning.
Negative_regulation (preventing) of MOR Binding (alterations) of in nucleus accumbens associated with nucleus accumbens, opioid receptor, methadone and cocaine
8) Confidence 0.27 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16237390 Disease Relevance 0.08 Pain Relevance 1.42
However, MCD treatment had opposite impacts on MOR signaling in the two tissues: it attenuated MOR-mediated [(35)S]GTPgammaS binding in CPu but enhanced it in CHO-HA-rMOR.
Negative_regulation (attenuated) of MOR-mediated Binding (binding) of in CPu associated with mu opioid receptor
9) Confidence 0.22 Published 2007 Journal Brain Res. Section Abstract Doc Link 17980352 Disease Relevance 0 Pain Relevance 0.79
Preincubation of membranes with MET-CI-CAMO and N-CPM-MET-Cl-CAMO produced a concentration-dependent, wash-resistant inhibition of mu-opioid receptor binding.
Negative_regulation (inhibition) of mu-opioid receptor Binding (binding) of associated with opioid receptor
10) Confidence 0.18 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9059844 Disease Relevance 0 Pain Relevance 0.80
We now report that the binding of mu-opioid receptor ligand, [3H][D-Ala2,NHPhe4,Gly-ol]enkephalin to membrane preparations of the pons/medulla was reduced by half in heterozygous mu-opioid receptor knockout mice and eliminated in homozygous mu-opioid receptor knockout mice.
Negative_regulation (eliminated) of mu-opioid receptor in pons Binding (binding) of in medulla associated with targeted disruption, medulla, enkephalin and opioid receptor
11) Confidence 0.14 Published 1999 Journal Neuroscience Section Abstract Doc Link 10613510 Disease Relevance 0.43 Pain Relevance 1.22
We now report that the binding of mu-opioid receptor ligand, [3H][D-Ala2,NHPhe4,Gly-ol]enkephalin to membrane preparations of the pons/medulla was reduced by half in heterozygous mu-opioid receptor knockout mice and eliminated in homozygous mu-opioid receptor knockout mice.
Negative_regulation (reduced) of mu-opioid receptor in pons Binding (binding) of in medulla associated with targeted disruption, medulla, enkephalin and opioid receptor
12) Confidence 0.14 Published 1999 Journal Neuroscience Section Abstract Doc Link 10613510 Disease Relevance 0.42 Pain Relevance 1.18
We now report that the binding of mu-opioid receptor ligand, [3H][D-Ala2,NHPhe4,Gly-ol]enkephalin to membrane preparations of the pons/medulla was reduced by half in heterozygous mu-opioid receptor knockout mice and eliminated in homozygous mu-opioid receptor knockout mice.
Negative_regulation (reduced) of mu-opioid receptor in pons Binding (binding) of in medulla associated with targeted disruption, medulla, enkephalin and opioid receptor
13) Confidence 0.14 Published 1999 Journal Neuroscience Section Abstract Doc Link 10613510 Disease Relevance 0.44 Pain Relevance 1.26
We now report that the binding of mu-opioid receptor ligand, [3H][D-Ala2,NHPhe4,Gly-ol]enkephalin to membrane preparations of the pons/medulla was reduced by half in heterozygous mu-opioid receptor knockout mice and eliminated in homozygous mu-opioid receptor knockout mice.
Negative_regulation (reduced) of mu-opioid receptor in pons Binding (binding) of in medulla associated with targeted disruption, medulla, enkephalin and opioid receptor
14) Confidence 0.14 Published 1999 Journal Neuroscience Section Abstract Doc Link 10613510 Disease Relevance 0.43 Pain Relevance 1.21
However, these compounds displayed drastically reduced mu receptor affinity in nearly all cases.
Negative_regulation (reduced) of mu receptor Binding (affinity) of
15) Confidence 0.13 Published 1996 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 8956074 Disease Relevance 0.06 Pain Relevance 0.75
The interaction between the MOR and GPR177 was initially uncovered in a MYTH screen and then validated in GST-pulldown and coimmunoprecipitation assays.
Negative_regulation (validated) of MOR Binding (interaction) of associated with opioid receptor
16) Confidence 0.12 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841195 Disease Relevance 0.07 Pain Relevance 0.86
O- and C-glycosylation of the mu-agonist dermorphin reduced neither its mu receptor affinity in binding assay nor its agonist potency in guinea-pig ileum assay (GPI).
Negative_regulation (reduced) of mu receptor Neg (neither) Binding (affinity) of in ileum associated with agonist and potency
17) Confidence 0.12 Published 1996 Journal Acta Physiol Hung Section Abstract Doc Link 9328626 Disease Relevance 0 Pain Relevance 0.58
Fentanyl and its congeners are of interest not only because of their clinical applications, but also because certain members of this series of opioid analgesics exhibit unique properties, such as acting as pseudoirreversible inhibitors of mu receptor binding, both in vitro and in vivo.
Negative_regulation (inhibitors) of mu receptor Binding (binding) of associated with analgesic and opioid
18) Confidence 0.05 Published 1993 Journal Synapse Section Abstract Doc Link 8153877 Disease Relevance 0.13 Pain Relevance 0.27
The present study was undertaken to determine the stereochemical requirements for pseudoirreversible inhibition of mu receptor binding using the methylfentanyl congeners, (+-)-cis-N-[1-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperidyl]-N- phenylpropanamide HCl (RTI-4614-4) and its four resolved enantiomers.
Negative_regulation (inhibition) of mu receptor Binding (binding) of associated with respiratory tract infection
19) Confidence 0.05 Published 1993 Journal Synapse Section Abstract Doc Link 8153877 Disease Relevance 0.17 Pain Relevance 0.24
Stereochemical requirements for pseudoirreversible inhibition of opioid mu receptor binding by the 3-methylfentanyl congeners, RTI-46144 and its enantiomers: evidence for different binding domains.
Negative_regulation (inhibition) of mu receptor Binding (binding) of associated with respiratory tract infection, enkephalin and opioid
20) Confidence 0.04 Published 1993 Journal Synapse Section Title Doc Link 8153877 Disease Relevance 0.16 Pain Relevance 0.43

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox