INT57256

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.55
First Reported 1994
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 52
Total Number 53
Disease Relevance 23.87
Pain Relevance 6.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DQA2) Golgi apparatus (HLA-DQA2) endoplasmic reticulum (HLA-DQA2)
plasma membrane (HLA-DQA2)
Anatomy Link Frequency
monocyte 6
CD86 4
DCs 3
GIM 2
T cell 2
HLA-DQA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 1 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
cytokine 352 99.52 Very High Very High Very High
Peripheral nervous system 8 99.52 Very High Very High Very High
Inflammation 457 99.32 Very High Very High Very High
Neuritis 13 99.20 Very High Very High Very High
spastic colon 21 98.40 Very High Very High Very High
Inflammatory response 107 97.98 Very High Very High Very High
epidural 11 97.88 Very High Very High Very High
Multiple sclerosis 43 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 584 99.32 Very High Very High Very High
Experimental Autoimmune Neuritis 10 99.20 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

12 98.54 Very High Very High Very High
Pre-term Labor 385 98.52 Very High Very High Very High
Functional Bowel Disorder 12 98.40 Very High Very High Very High
Cancer 298 98.00 Very High Very High Very High
Diarrhoea 6 97.72 Very High Very High Very High
Demyelinating Disease 40 97.44 Very High Very High Very High
Adenocarcinoma 91 97.04 Very High Very High Very High
Paresis 33 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
APC treated with the acid for a short time retained cell viability, MHC class II expression and antigen presenting cell function.
Gene_expression (expression) of MHC class II
1) Confidence 0.55 Published 2002 Journal Clin. Exp. Allergy Section Body Doc Link 12569986 Disease Relevance 0 Pain Relevance 0
The following peptides, cytokines, and antibodies had no effect on light chain acquisition or expression: substance P, vasoactive intestinal peptide, leu/met enkephalin, IL-1, IL-4, IL-7, anti-class II MHC, anti-CD24, anti-CD40, and the CD10 inhibitor phosphoramidon.
Gene_expression (expression) of anti-class II MHC associated with enkephalin, substance p and cytokine
2) Confidence 0.17 Published 1994 Journal Int. Immunol. Section Abstract Doc Link 8155604 Disease Relevance 0 Pain Relevance 0.20
In both murine and human systems, monocytes cultured with GM-CSF and IL-4 differentiate into immature DCs, which are characterized by low expression of MHC class II (MHC II) molecules as well as co-stimulatory molecules [38].
Gene_expression (expression) of MHC class II in DCs
3) Confidence 0.11 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.36 Pain Relevance 0.03
Concurrently, CD86high cells expressing intermediate levels of CD11c and high levels of MHC class II and F4/80, assessed by using flow cytometry, increased significantly in the regional lymph nodes, suggesting migration of these cells from the dental pulp.
Gene_expression (expressing) of MHC class II in dental pulp
4) Confidence 0.10 Published 2006 Journal Int. Immunol. Section Abstract Doc Link 16849394 Disease Relevance 0.24 Pain Relevance 0.05
Though DXA only assesses areal BMD of the lumbar spine, proximal femur, and distal radius, which includes cortical and trabecular bone, and has limitations in patients with degenerative disease, it has been shown to be robust and a good technique to determine fracture risk and measure response to therapy.


Gene_expression (assesses) of DXA in femur associated with disease
5) Confidence 0.10 Published 2010 Journal Skeletal Radiol Section Body Doc Link PMC2920421 Disease Relevance 0.57 Pain Relevance 0
After approximately 1 week the activated cells begin to express MHC class II.
Gene_expression (express) of MHC class II
6) Confidence 0.09 Published 2011 Journal Frontiers in Neurology Section Body Doc Link PMC3018771 Disease Relevance 0.32 Pain Relevance 0.03
The increase of some costimulatory markers but no or low enhancement of MHC class II expression could implicate impaired MHC II antigen presenting abilities.
Gene_expression (expression) of MHC class II
7) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 1.28 Pain Relevance 0.23
The impact of this is further substantiated by the fact that MHC class II is also abundantly expressed in the rheumatoid synovium [28]; thus, T cells have the potential to become reactivated locally in the joint.
Gene_expression (expressed) of MHC class II in joint
8) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833979 Disease Relevance 1.01 Pain Relevance 0.33
The HLA-DQA2 protein is expressed, but at a very low level in comparison with the HLA-DQA1 protein [15], [16].
Gene_expression (expressed) of HLA-DQA2
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2841168 Disease Relevance 0.11 Pain Relevance 0.06
That is, activated macrophages from aged humans and mice produce higher amounts of the proinflammatory paracrine molecule prostaglandin E2 than younger individuals, which inhibits surface expression of MHC class II [65].
Gene_expression (expression) of MHC class II in macrophages
10) Confidence 0.05 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2615427 Disease Relevance 0.36 Pain Relevance 0.14
Studies have indicated that this diminished MHC class II expression over the life span is typical in both humans and mice [64,65].
Gene_expression (expression) of MHC class II
11) Confidence 0.05 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2615427 Disease Relevance 0.11 Pain Relevance 0.04
Finally, the fourth mechanism is the modulation by statins of surface molecule expression and protein secretion; statins inhibit MHC class-II molecule expression on antigen presenting cells and endothelial cells [13], and CCR5 expression on T lymphocytes [18], while increases the secretion of RANTES and other cytokines [18].
Gene_expression (expression) of MHC class-II in T lymphocytes associated with cytokine
12) Confidence 0.05 Published 2009 Journal Trials Section Body Doc Link PMC2705367 Disease Relevance 0.37 Pain Relevance 0.12
No surface expression of MHC-Class II (data not shown) or CD90 could be seen on either tumor type.
Gene_expression (expression) of MHC-Class II associated with cancer
13) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.42 Pain Relevance 0.03
CONCLUSIONS: HLA-DQ2 expression and increased intestinal cd-associated antibodies are markers that can identify latent/potential cd in a subgroup of IBS patients who consequently appear to profit from a gluten-free diet.


Gene_expression (expression) of HLA-DQ2
14) Confidence 0.03 Published 2001 Journal Gastroenterology Section Body Doc Link 11729112 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Celiac disease-associated serum IgG and HLA-DQ2 expression can identify likely responders to gluten-free diet in d-IBS patients.


Gene_expression (expression) of HLA-DQ2
15) Confidence 0.03 Published 2007 Journal Clin. Gastroenterol. Hepatol. Section Body Doc Link 17553753 Disease Relevance 0 Pain Relevance 0
Data on genetic differences in VRA-induced expression of MHC class II in the G8 and a subset of animals from the G10 cohort has been presented previously [5].
Gene_expression (expression) of MHC class II
16) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691596 Disease Relevance 0.21 Pain Relevance 0.16
Vra1 and Vra2 were linked to neurodegeneration, Vra3 displayed suggestive linkage to T cell infiltration and Vra4 was linked to differential expression of MHC class II [11].
Gene_expression (expression) of MHC class II in T cell
17) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691596 Disease Relevance 0.31 Pain Relevance 0.12
There was a significant reduction of MHC Class II expression, as indicated by median fluorescence intensity (MFI), in those women who were positive for the bacterial ribosomal 16S gene by broad-range 16S rDNA endpoint PCR (p?
Gene_expression (expression) of MHC Class II
18) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785424 Disease Relevance 0.75 Pain Relevance 0
Expression of MHC Class II on blood monocytes was evaluated by staining heparinized blood (10 U/ml) with 5 µg/ml of MHC Class II-FITC and CD14-RPE conjugated monoclonal antibodies for 10 min at room temperature.
Gene_expression (Expression) of MHC Class II in monocytes
19) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785424 Disease Relevance 0.10 Pain Relevance 0.14
The observation that monocyte MHC Class II expression is also lower in women whose placenta was bacteria positive suggests that bacterial presence in membranes may contribute to the maternal, as well as chorio-decidual, inflammatory response.
Gene_expression (expression) of MHC Class II in placenta associated with inflammatory response
20) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785424 Disease Relevance 0.95 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox