INT57257

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Context Info
Confidence 0.62
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 69
Total Number 70
Disease Relevance 50.24
Pain Relevance 20.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL7) extracellular region (IL7) cell-cell signaling (IL7)
Anatomy Link Frequency
T cells 14
bone marrow 3
stromal cells 3
fibroblasts 2
Th2 cell 2
IL7 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 5889 100.00 Very High Very High Very High
cytokine 908 100.00 Very High Very High Very High
substance P 1 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
chemokine 154 98.92 Very High Very High Very High
methotrexate 69 97.88 Very High Very High Very High
Inflammation 655 97.72 Very High Very High Very High
Arthritis 184 97.68 Very High Very High Very High
cINOD 59 97.32 Very High Very High Very High
Inflammatory response 48 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 5904 100.00 Very High Very High Very High
Lymphopenia 696 99.82 Very High Very High Very High
Infection 182 99.64 Very High Very High Very High
Solid Tumor 156 99.26 Very High Very High Very High
Disease 1306 99.24 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 153 99.24 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 222 99.20 Very High Very High Very High
Cancer 877 98.44 Very High Very High Very High
Increased Venous Pressure Under Development 78 97.76 Very High Very High Very High
INFLAMMATION 766 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altogether, these findings suggest a deficit in circulating levels of IL-7 in RA, possibly due to an inability to produce IL-7, at least in stromal cells of bone marrow origin.


Gene_expression (produce) of IL-7 in bone marrow associated with rheumatoid arthritis
1) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.81 Pain Relevance 0.40
We therefore decided to investigate IL-7 levels in patients with well controlled disease and minimal levels of disease activity for at least 6 months before recruitment (n = 36; Table 1).
Spec (investigate) Gene_expression (levels) of IL-7 associated with disease
2) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 1.11 Pain Relevance 0.30
IL-7 production by bone marrow stromal cell cultures was also compromised in RA.
Gene_expression (production) of IL-7 in stromal cell associated with rheumatoid arthritis
3) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064881 Disease Relevance 1.05 Pain Relevance 0.33
We have also demonstrated low levels of lymphopenia-induced circulating IL-7 in RA patients (Fig. 4), and low basal IL-7 production from stromal cells originating from the bone marrow (Fig. 1).
Gene_expression (production) of IL-7 in stromal cells associated with lymphopenia and rheumatoid arthritis
4) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 1.57 Pain Relevance 0.50
In contrast, we found that basal serum IL-7 levels were reduced in a range of RA patients, irrespective of inflammation or medication (Fig. 1b).
Gene_expression (levels) of IL-7 associated with inflammation and rheumatoid arthritis
5) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.93 Pain Relevance 0.22
Importantly, in a cross-sectional comparison of 10 RA patients and 10 healthy control individuals, we could not find a significant difference in the number of cells expressing the IL-7 receptor (CD127) or in its level of expression (data not shown).
Gene_expression (expressing) of IL-7 associated with rheumatoid arthritis
6) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.78 Pain Relevance 0.39
This is associated with a reduced production of IL-7 in bone marrow derived stromal cell cultures, and may contribute to the defective CD4+ T-cell reconstitution that occurs following therapeutic lymphodepletion, primarily at the level of mature T-cell expansion in the periphery.
Gene_expression (production) of IL-7 in T-cell
7) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.64 Pain Relevance 0.21
We compared the ability of bone marrow stromal cells, derived from RA patients (n = 9) and healthy control individuals (n = 15), to produce IL-7 spontaneously in long-term cultures (Fig. 1c).
Gene_expression (produce) of IL-7 in bone marrow associated with rheumatoid arthritis
8) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.73 Pain Relevance 0.41
Lymphopenia-induced interleukin-7 production is defective in rheumatoid arthritis
Gene_expression (production) of interleukin-7 associated with lymphopenia and rheumatoid arthritis
9) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.78 Pain Relevance 0.25
Most importantly, there was no increase in serum IL-7 levels in RA, as compared with a fourfold rise in non-RA control individuals at the time of lymphopenia.
Gene_expression (levels) of IL-7 associated with lymphopenia and rheumatoid arthritis
10) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064881 Disease Relevance 1.38 Pain Relevance 0.49
The production of IL-7 was significantly lower in RA patients than in control individuals (P = 0.001).
Gene_expression (production) of IL-7 associated with rheumatoid arthritis
11) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.78 Pain Relevance 0.43
There are several sources of IL-7 production, including stromal cells in the bone marrow, dendritic cells and epithelial cells in the thymus, skin and gut [6].
Gene_expression (production) of IL-7 in epithelial cells
12) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.78 Pain Relevance 0.44
IL-7 is produced in response to lymphopenia [7] and stimulates proliferation of both naïve and memory human T-cells.
Gene_expression (produced) of IL-7 in T-cells associated with lymphopenia
13) Confidence 0.62 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.88 Pain Relevance 0.19
In one study [48] IL-7 was present at high levels in the serum of adult RA patients, and it correlated with CRP.
Gene_expression (present) of IL-7 associated with rheumatoid arthritis
14) Confidence 0.54 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 1.56 Pain Relevance 0.52
An aliquot of PBMCs was stained with a combination of CD127 (FITC; Serotec), CD19 (PE; Serotec) and CD4 or CD8 (PE-CY5; Serotec) to quantify IL-7 receptor expression on different cell types by flow cytometry.
Gene_expression (expression) of IL-7
15) Confidence 0.54 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.09 Pain Relevance 0.05
Furthermore, there was a positive correlation between the levels of circulating IL-7 and the TREC content of total CD4+ T cells (Fig. 5b; n = 36, all diamonds; R = 0.777, P < 0.00001).
Gene_expression (levels) of IL-7 in T cells
16) Confidence 0.54 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.08 Pain Relevance 0
An association between higher levels of IL-7 and thymic capacity to produce new T-cells was predictable, based on the direct stimulatory effect of IL-7 on thymic activity at many stages in T-cell progenitor development [6,11,56-60] High levels of IL-7, as detected in lymphopenic control patients, could therefore result in a burst of thymic activity.
Gene_expression (levels) of IL-7 in T-cell
17) Confidence 0.54 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.98 Pain Relevance 0.28
OA patients exhibited slightly lower IL-7 levels than did control individuals (P = 0.035) but they had significantly higher IL-7 levels than did RA patients (P < 0.00001).
Gene_expression (levels) of IL-7 associated with rheumatoid arthritis
18) Confidence 0.54 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.78 Pain Relevance 0.44
The relative deficiency in circulating IL-7 levels in RA patients identified in Fig. 1 therefore suggests a significant role for IL-7 in impaired T-cell reconstitution following high-dose chemotherapy.
Gene_expression (levels) of IL-7 in T-cell associated with rheumatoid arthritis
19) Confidence 0.54 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 1.00 Pain Relevance 0.35
In marked contrast, IL-7 levels did not change significantly in four RA patients over 12 months of follow up (squares).


Gene_expression (levels) of IL-7 associated with rheumatoid arthritis
20) Confidence 0.54 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 1.28 Pain Relevance 0.41

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