INT57258

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Context Info
Confidence 0.36
First Reported 1994
Last Reported 2009
Negated 5
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.28
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL7) extracellular region (IL7) cell-cell signaling (IL7)
Anatomy Link Frequency
T cells 6
IL7 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 494 100.00 Very High Very High Very High
substance P 1 100.00 Very High Very High Very High
Enkephalin 1 100.00 Very High Very High Very High
cytokine 108 99.52 Very High Very High Very High
Kinase C 1 71.56 Quite High
Inflammation 76 64.00 Quite High
antagonist 4 54.56 Quite High
Arthritis 32 52.80 Quite High
chemokine 17 51.84 Quite High
corticosteroid 3 23.60 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 497 100.00 Very High Very High Very High
Lymphopenia 41 99.82 Very High Very High Very High
Recurrence 3 90.32 High High
Disease 125 83.76 Quite High
Death 12 72.08 Quite High
INFLAMMATION 94 64.00 Quite High
Cancer 60 52.88 Quite High
Arthritis 25 52.80 Quite High
Autoimmune Disease 33 50.00 Quite Low
Apoptosis 17 30.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lymphopenia-induced interleukin-7 production is defective in rheumatoid arthritis
Regulation (defective) of Gene_expression (production) of interleukin-7 associated with lymphopenia and rheumatoid arthritis
1) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 0.83 Pain Relevance 0.27
In marked contrast, IL-7 levels did not change significantly in four RA patients over 12 months of follow up (squares).


Neg (not) Regulation (change) of Gene_expression (levels) of IL-7 associated with rheumatoid arthritis
2) Confidence 0.36 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064881 Disease Relevance 1.28 Pain Relevance 0.41
Effects of IL-7 versus IL-2 administration in selected T cell subpopulations
Regulation (Effects) of Gene_expression (administration) of IL-7 in T cell
3) Confidence 0.31 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0 Pain Relevance 0.05
production of CD4+ T cells in RA patients by IL-7 alone, by IL-4 alone or by IL-7 and IL-4 was not significantly different from healthy controls (Fig. 3, left panel).
Neg (not) Regulation (different) of Gene_expression (production) of IL-7 in T cells associated with rheumatoid arthritis
4) Confidence 0.28 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.64 Pain Relevance 0.32
production by IL-7 and IL-4 was significantly different from IL-7 alone, but not statistically different from IL-4 alone.
Neg (not) Regulation (different) of Gene_expression (production) of IL-7
5) Confidence 0.28 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.29 Pain Relevance 0.15
production of CD4+ T cells in RA patients by IL-7 alone, by IL-4 alone or by IL-7 and IL-4 was not significantly different from healthy controls (Fig. 3, left panel).
Neg (not) Regulation (different) of Gene_expression (production) of IL-7 in T cells associated with rheumatoid arthritis
6) Confidence 0.28 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.64 Pain Relevance 0.32
TCR diversity spectratype analysis was performed on sorted CD4+ and CD8+ populations before and after (day 21) rhIL-7 therapy in 6 subjects treated at either 30 or 60 ?
Regulation (performed) of Gene_expression (therapy) of rhIL-7
7) Confidence 0.27 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0 Pain Relevance 0
The following peptides, cytokines, and antibodies had no effect on light chain acquisition or expression: substance P, vasoactive intestinal peptide, leu/met enkephalin, IL-1, IL-4, IL-7, anti-class II MHC, anti-CD24, anti-CD40, and the CD10 inhibitor phosphoramidon.
Neg (no) Regulation (effect) of Gene_expression (expression) of IL-7 associated with enkephalin, substance p and cytokine
8) Confidence 0.13 Published 1994 Journal Int. Immunol. Section Abstract Doc Link 8155604 Disease Relevance 0 Pain Relevance 0.20
High levels of IL-7 and IL-15 mRNA and protein expression have been demonstrated in synovial tissue cells from RA patients [41].
Regulation (levels) of Gene_expression (expression) of IL-7 associated with rheumatoid arthritis
9) Confidence 0.04 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.61 Pain Relevance 0.40

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