INT57273

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Context Info
Confidence 0.47
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 17.83
Pain Relevance 4.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (FN1) extracellular region (FN1) cell adhesion (FN1)
proteinaceous extracellular matrix (FN1)
Anatomy Link Frequency
plasma 6
fibroblasts 6
dental pulp 4
nerve 2
skin 2
FN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 37 100.00 Very High Very High Very High
Nerve growth factor 19 100.00 Very High Very High Very High
dexamethasone 27 99.98 Very High Very High Very High
Chronic pancreatitis 99 98.76 Very High Very High Very High
rheumatoid arthritis 79 98.28 Very High Very High Very High
Pain 40 96.20 Very High Very High Very High
Osteoarthritis 27 93.12 High High
chemokine 23 92.12 High High
vincristine 16 90.08 High High
metalloproteinase 10 84.56 Quite High
Disease Link Frequency Relevance Heat
Neutropenia 289 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 211 100.00 Very High Very High Very High
Boutonneuse Fever 82 100.00 Very High Very High Very High
Fever 41 100.00 Very High Very High Very High
Leukemia 19 100.00 Very High Very High Very High
Contact Dermatitis 28 99.68 Very High Very High Very High
Mixed Connective Tissue Disorder 1 99.62 Very High Very High Very High
Lymphatic System Cancer 93 99.20 Very High Very High Very High
Uterine Fibroids 360 99.00 Very High Very High Very High
Wound Healing 35 98.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexamethasone promotes fibronectin synthesis and suppresses NGF secretion, suggesting that this reagent could be used clinically to reduce pain and promote dental pulp tissue healing.
Positive_regulation (promotes) of Gene_expression (synthesis) of fibronectin in dental pulp associated with pain, nerve growth factor and dexamethasone
1) Confidence 0.47 Published 2007 Journal J Endod Section Abstract Doc Link 17931932 Disease Relevance 0.24 Pain Relevance 0.71
TGF-beta1 increased expression and synthesis of both fibronectin and nerve growth factor (NGF), whereas dexamethasone stimulated fibronectin synthesis but inhibited NGF expression.
Positive_regulation (stimulated) of Gene_expression (synthesis) of fibronectin in nerve associated with nerve growth factor and dexamethasone
2) Confidence 0.47 Published 2007 Journal J Endod Section Abstract Doc Link 17931932 Disease Relevance 0.16 Pain Relevance 0.70
Severity of MSF varies according to the time.
Positive_regulation (Severity) of Gene_expression (Severity) of MSF associated with boutonneuse fever
3) Confidence 0.41 Published 2008 Journal Emerging Infectious Diseases Section Body Doc Link PMC2603122 Disease Relevance 1.56 Pain Relevance 0
Different roles of dexamethasone on transforming growth factor-beta1-induced fibronectin and nerve growth factor expression in dental pulp cells.
Positive_regulation (induced) of Gene_expression (expression) of fibronectin in dental pulp associated with nerve growth factor and dexamethasone
4) Confidence 0.34 Published 2007 Journal J Endod Section Title Doc Link 17931932 Disease Relevance 0.19 Pain Relevance 0.60
RESULTS: TGF-beta1 significantly stimulated alpha-SMA, collagen I and fibronectin production in peritoneal fibroblasts.
Positive_regulation (stimulated) of Gene_expression (production) of fibronectin in fibroblasts
5) Confidence 0.21 Published 2010 Journal Med. Sci. Monit. Section Body Doc Link 20671605 Disease Relevance 0.08 Pain Relevance 0
Wound healing and connective tissue disorders may respond to an increase in fibroblast collagenases and decreased collagen, fibronectin, and glycosaminoglycan production.
Positive_regulation (increase) of Gene_expression (production) of fibronectin in fibroblast associated with wound healing and mixed connective tissue disorder
6) Confidence 0.17 Published 1994 Journal J. Am. Acad. Dermatol. Section Abstract Doc Link 8157787 Disease Relevance 0.94 Pain Relevance 0.06
For laminin and fibronectin coating, dishes were pretreated with PDL as described above, fibronectin derived from human plasma (R & D Systems, Minneapolis, MN; ) was added at 50 ?
Positive_regulation (pretreated) of Gene_expression (coating) of fibronectin in plasma
7) Confidence 0.17 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570688 Disease Relevance 0.22 Pain Relevance 0
For laminin and fibronectin coating, dishes were pretreated with PDL as described above, fibronectin derived from human plasma (R & D Systems, Minneapolis, MN; ) was added at 50 ?
Positive_regulation (For) of Gene_expression (coating) of fibronectin in plasma
8) Confidence 0.17 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570688 Disease Relevance 0.22 Pain Relevance 0
Blockade of the CB2-receptor by AM630 did also not change collagen 1 and fibronectin production (Figure 4).
Neg (not) Positive_regulation (change) of Gene_expression (production) of fibronectin
9) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.17 Pain Relevance 0.20
For these reasons, we selected fibronectin, vitronectin, and Coll.I for our study of RA-FLS adhesion.
Positive_regulation (selected) of Gene_expression (selected) of fibronectin associated with rheumatoid arthritis and adhesions
10) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 1.52 Pain Relevance 0.63
Particularly, while there was a tendency towards an increase in fibronectin production following PSC co-culture with CP and septic shock PBMC, this increase could also have been due to activation of PSC under culture conditions (plastic cell culture dishes which lead to activation of PSC).
Positive_regulation (increase) of Gene_expression (production) of fibronectin associated with primary sclerosing cholangitis, chronic pancreatitis and sepsis
11) Confidence 0.15 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 1.50 Pain Relevance 0.43
Fibronectin expression in response to ATRA exposure
Positive_regulation (response) of Gene_expression (expression) of Fibronectin
12) Confidence 0.14 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.59 Pain Relevance 0
Again, fibronectin protein production in the presence of ATRA was comparable between leiomyoma and myometrial cells.


Positive_regulation (presence) of Gene_expression (production) of fibronectin protein associated with uterine fibroids
13) Confidence 0.14 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.94 Pain Relevance 0
As shown in Table 1, untreated leiomyoma cells demonstrated a 2·18 ± 0·12-fold (P < 0·05) increase in fibronectin mRNA expression compared to myometrial cells.
Positive_regulation (increase) of Gene_expression (expression) of fibronectin mRNA associated with uterine fibroids
14) Confidence 0.14 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.74 Pain Relevance 0
Here, PBMC derived from healthy donors led to a 71% increase in PSC fibronectin levels after 24 hours of co-incubation (Figure 4B).
Positive_regulation (increase) of Gene_expression (levels) of fibronectin associated with primary sclerosing cholangitis
15) Confidence 0.13 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.83 Pain Relevance 0.19
Since induction of CS-1 fibronectin production has also been reported by us in lesional skin from patients with atopic dermatitis and irritative contact dermatitis [Martín AP; Ortiz S; Cabalier MED; Frede S; Burgos E; Hliba E; Serra, HM.
Positive_regulation (induction) of Gene_expression (production) of fibronectin in skin associated with contact dermatitis and dermatitis
16) Confidence 0.09 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 1.09 Pain Relevance 0.18
G-CSF prophylaxis is now recommended when the overall risk of febrile neutropenia (FN) due to regimen and individual patient factors is ?
Positive_regulation (overall) of Gene_expression (overall) of FN associated with neutropenia and fever
17) Confidence 0.09 Published 2010 Journal Support Care Cancer Section Abstract Doc Link PMC2846279 Disease Relevance 0.58 Pain Relevance 0
TGFbeta1 treatment upregulated the expression of alphaSMA, collagen type I (Col I), fibronectin and TGFbeta1.
Positive_regulation (upregulated) of Gene_expression (expression) of fibronectin
18) Confidence 0.08 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 16127427 Disease Relevance 1.09 Pain Relevance 0.12
305) patients undergoing chemotherapy found that first-cycle FN, age ?
Positive_regulation (undergoing) of Gene_expression (undergoing) of FN associated with neutropenia
19) Confidence 0.08 Published 2010 Journal Support Care Cancer Section Body Doc Link PMC2846279 Disease Relevance 0.88 Pain Relevance 0
Regimens with an overall risk of FN of ?
Positive_regulation (overall) of Gene_expression (overall) of FN associated with neutropenia
20) Confidence 0.08 Published 2010 Journal Support Care Cancer Section Body Doc Link PMC2846279 Disease Relevance 1.04 Pain Relevance 0.05

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