INT57274

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Context Info
Confidence 0.69
First Reported 1994
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 50
Total Number 50
Disease Relevance 24.19
Pain Relevance 4.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL7A1) cell adhesion (COL7A1)
Anatomy Link Frequency
extracellular matrix 10
chondrocyte 8
osteoblasts 6
tendons 6
smooth muscle 4
COL7A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 100 100.00 Very High Very High Very High
Osteoarthritis 203 99.84 Very High Very High Very High
imagery 161 99.32 Very High Very High Very High
Inflammation 237 99.12 Very High Very High Very High
Inflammatory mediators 4 96.96 Very High Very High Very High
rheumatoid arthritis 51 95.40 Very High Very High Very High
Pain 133 95.24 Very High Very High Very High
carpal tunnel syndrome 10 92.12 High High
cINOD 57 91.88 High High
headache 4 88.48 High High
Disease Link Frequency Relevance Heat
Fibrosis 68 100.00 Very High Very High Very High
Osteoporosis 47 100.00 Very High Very High Very High
Injury 787 99.98 Very High Very High Very High
Wound Healing 352 99.84 Very High Very High Very High
Knee Osteoarthritis 49 99.84 Very High Very High Very High
Mixed Connective Tissue Disorder 1 99.62 Very High Very High Very High
Hypercalcemia 38 99.44 Very High Very High Very High
INFLAMMATION 277 99.12 Very High Very High Very High
Channelopathies 5 99.12 Very High Very High Very High
Tendinopathy 133 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ascorbate is essential for collagen production, and vitamin C deficiency will result in defective connective tissue, including reductions in collagen synthesis and structural stability.
Positive_regulation (essential) of Gene_expression (production) of collagen in connective tissue
1) Confidence 0.69 Published 2010 Journal Med. Hypotheses Section Abstract Doc Link 19932568 Disease Relevance 0.99 Pain Relevance 0.09
After training, collagen synthesis was increased in the initially injured tendon (n=6; carboxyterminal propeptide of type I collagen (PICP): pre 3.9+/-2.5 microg/L to post 19.7+/-5.4 microg/L, P<0.05).
Positive_regulation (increased) of Gene_expression (synthesis) of collagen in tendon
2) Confidence 0.68 Published 2007 Journal Scand J Med Sci Sports Section Abstract Doc Link 16787448 Disease Relevance 0.38 Pain Relevance 0.07
Our studies show that the glycation of human corneal and scleral collagen produces increases in the collagen intermolecular spacing-these increases are similar to those we previously reported on the ageing of collagen in these tissues.
Positive_regulation (increases) of Gene_expression (produces) of collagen associated with aging
3) Confidence 0.50 Published 1996 Journal Age Ageing Section Abstract Doc Link 8831872 Disease Relevance 0.73 Pain Relevance 0.11
This results in faster cell division, rapid matrix production (increased collagen, myofibroblasts, etc.), and cell movement.
Positive_regulation (results) of Gene_expression (production) of collagen
4) Confidence 0.50 Published 1999 Journal J Mass Dent Soc Section Abstract Doc Link 10740521 Disease Relevance 0.16 Pain Relevance 0
This results in faster cell division, rapid matrix production (increased collagen, myofibroblasts, etc.), and cell movement.
Positive_regulation (increased) of Gene_expression (production) of collagen
5) Confidence 0.50 Published 1999 Journal J Mass Dent Soc Section Abstract Doc Link 10740521 Disease Relevance 0.16 Pain Relevance 0
The present study demonstrates that chronically injured Achilles tendons respond to 12 weeks of eccentric training by increasing collagen synthesis rate.
Positive_regulation (increasing) of Gene_expression (synthesis) of collagen in tendons
6) Confidence 0.49 Published 2007 Journal Scand J Med Sci Sports Section Abstract Doc Link 16787448 Disease Relevance 0.16 Pain Relevance 0.09
Eccentric rehabilitation exercise increases peritendinous type I collagen synthesis in humans with Achilles tendinosis.
Positive_regulation (increases) of Gene_expression (synthesis) of collagen associated with tendinopathy
7) Confidence 0.43 Published 2007 Journal Scand J Med Sci Sports Section Title Doc Link 16787448 Disease Relevance 0.45 Pain Relevance 0.10
They also had increased rates of collagen synthesis, alkaline phosphatase activity, and cell proliferation compared with the normal osteoblasts.
Positive_regulation (increased) of Gene_expression (synthesis) of collagen in osteoblasts
8) Confidence 0.38 Published 1997 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 9308541 Disease Relevance 0.57 Pain Relevance 0.07
Ascorbic acid stimulates type I collagen production more in FR control than in FR-CTS.
Positive_regulation (stimulates) of Gene_expression (production) of collagen
9) Confidence 0.37 Published 2000 Journal J. Occup. Environ. Med. Section Abstract Doc Link 10738704 Disease Relevance 0.25 Pain Relevance 0.25
Growth factor treatment resulted in the following responses by the cells: (1) a higher mitogenic response than in the control cells; (2) a higher stimulation of type III collagen production and a lower stimulation of type I collagen production in CTS cells as compared with control cells; and (3) more alpha 2 (I) than alpha 1 (I) collagen production in CTS cells, unlike in control cells.
Positive_regulation (stimulation) of Gene_expression (production) of collagen
10) Confidence 0.37 Published 2000 Journal J. Occup. Environ. Med. Section Abstract Doc Link 10738704 Disease Relevance 0.23 Pain Relevance 0.23
The effect of periodontal inflammation on the pulp is controversial and conflicting studies abound.[112033–36] It has been suggested that periodontal disease has no effect on the pulp, at least until it involves the apex.[34] On the other hand, several studies suggested that the effect of periodontal disease on the pulp is degenerative in nature including an increase in calcifications, fibrosis and collagen resorption, as well as a direct inflammatory effect.[3738] However, it seems that the pulp is not directly affected by periodontal disease, until recession has opened up an accessory canal to the oral environment.
Positive_regulation (increase) of Gene_expression (resorption) of collagen in canal associated with fibrosis, inflammation and periodontal disease
11) Confidence 0.34 Published 2008 Journal Journal of Conservative Dentistry : JCD Section Body Doc Link PMC2813095 Disease Relevance 1.07 Pain Relevance 0.15
RESULTS: In pancreatitis tissue, an increase in collagen content, collagenolytic activity and beta 1 integrin expression were accompanied by significant decrease (about 2-fold) in prolidase activity and marked decrease in its expression, compared to normal pancreas.
Positive_regulation (increase) of Gene_expression (expression) of collagen in pancreas
12) Confidence 0.28 Published 2002 Journal Hepatogastroenterology Section Body Doc Link 12397770 Disease Relevance 0.17 Pain Relevance 0
Although heterotopic ossification derived cells functioned qualitatively like osteoblasts, they exhibited elevated levels of activities traditionally ascribed to osteoblasts, such as collagen synthesis and alkaline phosphatase activity.
Positive_regulation (elevated) of Gene_expression (synthesis) of collagen in osteoblasts associated with heterotopic ossification
13) Confidence 0.27 Published 1997 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 9308541 Disease Relevance 0.47 Pain Relevance 0.05
The expression of COL7A1 template was increased by ATRA exposure, resulting in similar comparable expression.
Positive_regulation (increased) of Gene_expression (expression) of COL7A1
14) Confidence 0.26 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.64 Pain Relevance 0
In the vitamin C–deficient group, the abscesses formed were much larger than those in the control group, which was attributed to impaired collagen production in the test animals, leading to inadequate sequestration or “walling off” of the bacteria.139 Neutrophils are also affected in vitamin C deficiency: as vitamin C is required to reduce oxygen to superoxide, free radical production is decreased and neutrophil function is impaired.2
Positive_regulation (attributed) of Gene_expression (production) of collagen in neutrophil associated with abscess
15) Confidence 0.25 Published 2008 Journal Eplasty Section Body Doc Link PMC2206003 Disease Relevance 0.96 Pain Relevance 0
Vitamin C is necessary for hydroxylation of proline and lysine residues in collagen polymerization and cross-linking.105 Hydroxyproline is essential for the helical stability of collagen and its subsequent secretion into the extracellular matrix, while hydroxylysine is required for collagen cross-linking and further polymerization of fibers.2 In the absence of vitamin C, collagen formation is poor, and the unhydroxylated protein is susceptible to proteolysis.135 This leads to weakness of the extracellular matrix and the clinical condition scurvy, manifested by abnormal wound healing.2
Positive_regulation (required) of Gene_expression (cross) of collagen in extracellular matrix associated with scurvy and wound healing
16) Confidence 0.25 Published 2008 Journal Eplasty Section Body Doc Link PMC2206003 Disease Relevance 0.73 Pain Relevance 0
Indomethacin and 5,5-dimethyl-3-(3 fluorophenyl)-4-(4 methylsulphonal) phenyl-2 (5H)-furanone (DFU) reduced osteoblast numbers in a dose-dependant manner and increased collagen synthesis and alkaline phosphatase activity.
Positive_regulation (increased) of Gene_expression (synthesis) of collagen in osteoblast associated with osteoporosis
17) Confidence 0.24 Published 2004 Journal J Bone Joint Surg Br Section Abstract Doc Link 15125136 Disease Relevance 0.44 Pain Relevance 0.72
However, it is important to also consider increased collagen synthesis and other extracellular matrix proteins.
Positive_regulation (increased) of Gene_expression (synthesis) of collagen in extracellular matrix
18) Confidence 0.23 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993941 Disease Relevance 0.24 Pain Relevance 0.16
FOY-007 attenuated the collagen synthesis and PIP production stimulated by TGF-beta1 dose dependently, but FOY-305 inhibited only PIP production.
Positive_regulation (stimulated) of Gene_expression (synthesis) of collagen
19) Confidence 0.22 Published 2001 Journal Pancreas Section Abstract Doc Link 11291936 Disease Relevance 0.13 Pain Relevance 0.14
FOY-007 attenuated the collagen synthesis and PIP production stimulated by TGF-beta1 dose dependently, but FOY-305 inhibited only PIP production.
Positive_regulation (stimulated) of Gene_expression (production) of collagen
20) Confidence 0.22 Published 2001 Journal Pancreas Section Abstract Doc Link 11291936 Disease Relevance 0.13 Pain Relevance 0.14

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