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Context Info
Confidence 0.19
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.15
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ANGPTL5) extracellular space (ANGPTL5) extracellular region (ANGPTL5)
Anatomy Link Frequency
pituitary 1
platelet 1
mast cells 1
ANGPTL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 45 100.00 Very High Very High Very High
Inflammatory response 48 98.96 Very High Very High Very High
cytokine 203 87.36 High High
Restless leg syndrome 1 68.56 Quite High
antagonist 36 54.68 Quite High
chemokine 7 44.08 Quite Low
cva 30 24.88 Low Low
imagery 7 5.00 Very Low Very Low Very Low
Antihistamine 6 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 94 100.00 Very High Very High Very High
Adhesions 4 98.36 Very High Very High Very High
Foreign Bodies 18 94.08 High High
Wound Healing 1 91.92 High High
Hemorrhage 130 91.68 High High
Mixed Connective Tissue Disorder 1 90.48 High High
Necrosis 4 89.52 High High
Cancer 5 89.16 High High
Increased Venous Pressure Under Development 12 68.56 Quite High
Injury 212 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Histamine release and fibrinogen adsorption mediate acute inflammatory responses to biomaterial implants in humans


Localization (release) of fibrinogen associated with inflammatory response
1) Confidence 0.19 Published 2007 Journal J Transl Med Section Title Doc Link PMC1929055 Disease Relevance 0.42 Pain Relevance 0.19
The results from animal studies suggest that both fibrinogen adsorption to the implant surface and histamine release by local mast cells are involved in biomaterial-mediated acute inflammatory responses.
Localization (release) of fibrinogen in mast cells associated with inflammatory response
2) Confidence 0.19 Published 2007 Journal J Transl Med Section Abstract Doc Link PMC1929055 Disease Relevance 0.35 Pain Relevance 0.13
Fibrinogen and cryoprecipitate
Localization (cryoprecipitate) of Fibrinogen
3) Confidence 0.15 Published 2010 Journal Crit Care Section Body Doc Link PMC2887168 Disease Relevance 0.18 Pain Relevance 0
Hypercoagulable states improve through decreased platelet aggregation and adhesion, increased plasminogen activator, increased plasmin, increased antithrombin III, decreased fibrinogen, decreased alpha 2-antiplasmin, decreased alpha 1-antitrypsin, and decreased alpha 2-macroglobulin.
Localization (decreased) of fibrinogen in platelet associated with adhesions
4) Confidence 0.06 Published 1994 Journal J. Am. Acad. Dermatol. Section Abstract Doc Link 8157787 Disease Relevance 0.93 Pain Relevance 0.07
These multiple responses include induction of the acute-phase response (e.g., C-reactive protein, fibrinogen), activation of the hypothalamic-pituitary-adrenal axis (with attendant anti-inflammatory affects), growth hormone secretion, and reduction of human serum cholesterol (Papanicolaou et al., 1998).
Localization (secretion) of fibrinogen in pituitary associated with inflammation
5) Confidence 0.00 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.27 Pain Relevance 0.45

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