INT57278

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Context Info
Confidence 0.81
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.59
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINA1) extracellular region (SERPINA1) proteinaceous extracellular matrix (SERPINA1)
Anatomy Link Frequency
liver 1
monocytes 1
platelet 1
SERPINA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 4 99.20 Very High Very High Very High
Inflammatory mediators 2 67.12 Quite High
Restless leg syndrome 1 66.44 Quite High
Inflammation 9 61.36 Quite High
alcohol 2 51.52 Quite High
Potency 23 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystic Fibrosis 2 99.20 Very High Very High Very High
Adhesions 2 97.30 Very High Very High Very High
Wound Healing 1 96.88 Very High Very High Very High
Mixed Connective Tissue Disorder 1 95.44 Very High Very High Very High
Congenital Anomalies 4 91.92 High High
Coagulation Disorder 6 87.92 High High
Disease Progression 1 87.76 High High
Necrosis 5 87.40 High High
Pulmonary Emphysema 6 87.20 High High
Cancer 3 87.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The protein alpha-1-antitrypsin is a 52 kDa molecule produced primarily in hepatocytes and released into the blood circulation by the liver [5].
Localization (released) of alpha-1-antitrypsin in liver
1) Confidence 0.81 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0.92 Pain Relevance 0.08
Likewise, Z-type alpha-1-antitrypsin from monocytes also polymerize within these cells and can only be secreted at very low levels.


Localization (secreted) of Z-type alpha-1-antitrypsin in monocytes
2) Confidence 0.70 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 0.45 Pain Relevance 0.03
In 2003, two other preparations of alpha1-PI, Aralast (Baxter, Westlake Village, California, USA) and Zemaira (CSL Behring, Kankakee, Illinois, USA) were introduced in the United States.
Localization (preparations) of alpha1-PI
3) Confidence 0.58 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2958874 Disease Relevance 0.29 Pain Relevance 0.03
Hypercoagulable states improve through decreased platelet aggregation and adhesion, increased plasminogen activator, increased plasmin, increased antithrombin III, decreased fibrinogen, decreased alpha 2-antiplasmin, decreased alpha 1-antitrypsin, and decreased alpha 2-macroglobulin.
Localization (decreased) of alpha 1-antitrypsin in platelet associated with adhesions
4) Confidence 0.26 Published 1994 Journal J. Am. Acad. Dermatol. Section Abstract Doc Link 8157787 Disease Relevance 0.94 Pain Relevance 0.07

General Comments

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