INT57282

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Context Info
Confidence 0.49
First Reported 1994
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.84
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
dorsal 3
striatum 2
ventral 1
Penk (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 12 100.00 Very High Very High Very High
ischemia 2 99.98 Very High Very High Very High
Nicotine 14 99.70 Very High Very High Very High
Neurotransmitter 3 91.08 High High
Analgesic 7 86.64 High High
antagonist 2 77.20 Quite High
Dopamine 2 76.00 Quite High
Glutamate receptor 2 75.00 Quite High
Glutamate 6 72.72 Quite High
gABA 6 65.92 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 2 99.98 Very High Very High Very High
Hypoxia 6 99.80 Very High Very High Very High
Injury 4 93.52 High High
Brain Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The addition of enzyme inhibitors and absorption enhancers markedly increased the inhibition rate of Leu-Enk and YAGFL; their inhibition rates were about four times and twice those without any enzyme inhibitor or absorption enhancer, respectively.
Positive_regulation (increased) of Negative_regulation (inhibition) of Enk
1) Confidence 0.49 Published 2003 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 14604463 Disease Relevance 0 Pain Relevance 0.45
A single dose of nicotine given to mice induces first a rapid decrease (presumed release/enhanced degradation) and then a rise (presumed synthesis/enhanced accumulation) of met-enkephalin (Met-Enk) in dorsal and ventral striatum observed at 30 and 60 min post-treatment, respectively.
Positive_regulation (induces) of Negative_regulation (decrease) of Met-Enk in dorsal associated with nicotine and enkephalin
2) Confidence 0.28 Published 2000 Journal Brain Res. Section Abstract Doc Link 10996137 Disease Relevance 0 Pain Relevance 0.72
Hypoxia-ischemia results in an early (up to 24 h) decrease in striatal preproenkephalin mRNA, which is shown by in situ hybridization to occur mainly in the dorsal portion of the striatum.
Positive_regulation (results) of Negative_regulation (decrease) of preproenkephalin mRNA in striatum associated with hypoxia and ischemia
3) Confidence 0.10 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8158136 Disease Relevance 0.84 Pain Relevance 0.37
A single dose of nicotine given to mice induces first a rapid decrease (presumed release/enhanced degradation) and then a rise (presumed synthesis/enhanced accumulation) of met-enkephalin (Met-Enk) in dorsal and ventral striatum observed at 30 and 60 min post-treatment, respectively.
Positive_regulation (induces) of in ventral Negative_regulation (decrease) of Met-Enk in dorsal associated with nicotine and enkephalin
4) Confidence 0.10 Published 2000 Journal Brain Res. Section Abstract Doc Link 10996137 Disease Relevance 0 Pain Relevance 0.72

General Comments

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