INT57326

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Context Info
Confidence 0.44
First Reported 1994
Last Reported 2008
Negated 0
Speculated 2
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 2.08
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2B6) endoplasmic reticulum (CYP2B6)
Anatomy Link Frequency
hepatocytes 4
placenta 3
lung 1
CYP2B6 (Homo sapiens)
Pain Link Frequency Relevance Heat
fortral 6 93.32 High High
fluoxetine 8 71.52 Quite High
Potency 2 57.76 Quite High
diclofenac 2 41.92 Quite Low
Nicotine 6 34.56 Quite Low
Versed 2 32.80 Quite Low
beta blocker 2 25.00 Low Low
analgesia 2 25.00 Low Low
Opioid 2 25.00 Low Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 9 99.98 Very High Very High Very High
Rickets 12 99.78 Very High Very High Very High
Nicotine Addiction 26 99.60 Very High Very High Very High
Cancer 2 95.04 Very High Very High Very High
Infection 7 89.00 High High
Hypercalcemia 6 83.24 Quite High
Lung Cancer 2 80.16 Quite High
Recurrence 2 79.40 Quite High
Hypocalcemia 2 71.16 Quite High
Thrombosis 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Polycyclic aromatic hydrocarbons in tobacco smoke are believed to be responsible for the induction of cytochrome P450 (CYP) 1A1, CYP1A2 and possibly CYP2E1, CYP1A1 is primarily an extrahepatic enzyme found in lung and placenta.
Spec (possibly) Regulation (responsible) of Spec (possibly) Positive_regulation (induction) of P450 in placenta associated with nicotine addiction
1) Confidence 0.44 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10427467 Disease Relevance 0.59 Pain Relevance 0
Primary human hepatocytes in culture are commonly used to evaluate cytochrome P450 (P450) induction via an enzyme activity endpoint.
Regulation (evaluate) of Positive_regulation (induction) of P450 in hepatocytes
2) Confidence 0.39 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16679385 Disease Relevance 0 Pain Relevance 0.07
Primary human hepatocytes in culture are commonly used to evaluate cytochrome P450 (P450) induction via an enzyme activity endpoint.
Regulation (evaluate) of Positive_regulation (induction) of P450 in hepatocytes
3) Confidence 0.39 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16679385 Disease Relevance 0 Pain Relevance 0.07
Polycyclic aromatic hydrocarbons in tobacco smoke are believed to be responsible for the induction of cytochrome P450 (CYP) 1A1, CYP1A2 and possibly CYP2E1, CYP1A1 is primarily an extrahepatic enzyme found in lung and placenta.
Spec (possibly) Regulation (responsible) of in lung Spec (possibly) Positive_regulation (induction) of P450 in placenta associated with nicotine addiction
4) Confidence 0.15 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10427467 Disease Relevance 0.59 Pain Relevance 0
Osteomalacia in an HIV-infected man receiving rifabutin, a cytochrome P450 enzyme inducer: a case report

Introduction

Regulation (infected) of Positive_regulation (inducer) of P450 associated with rickets and acquired immune deficiency syndrome or hiv infection
5) Confidence 0.10 Published 2008 Journal Ann Clin Microbiol Antimicrob Section Title Doc Link PMC2253556 Disease Relevance 0.91 Pain Relevance 0
The inhibitory effects of representative sigma compounds and cytochrome P450 inhibitors were evaluated in guinea pig tissues, and the effects of cytochrome P450 induction on sigma binding in the rat were investigated.
Regulation (effects) of Positive_regulation (induction) of P450
6) Confidence 0.06 Published 1994 Journal Biochem. Pharmacol. Section Abstract Doc Link 8161352 Disease Relevance 0 Pain Relevance 0.28

General Comments

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