INT57336

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Context Info
Confidence 0.46
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 11
Disease Relevance 4.80
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lungs 3
T cells 2
Synovial cells 1
Cd19 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 112 98.72 Very High Very High Very High
cytokine 99 91.76 High High
Spinal cord 5 86.64 High High
Arthritis 7 83.36 Quite High
headache 1 82.16 Quite High
Inflammation 42 79.48 Quite High
imagery 21 71.12 Quite High
Sciatic nerve 7 67.00 Quite High
spinal inflammation 4 50.00 Quite Low
methotrexate 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Emphysema 238 97.92 Very High Very High Very High
Autoimmune Disease 42 97.68 Very High Very High Very High
Lymphatic System Cancer 1 93.20 High High
Immunization 126 91.28 High High
Syndrome 10 90.64 High High
Congenital Anomalies 1 90.28 High High
Multiple Myeloma 26 87.44 High High
Spinal Cord Compression 4 87.12 High High
INFLAMMATION 29 86.20 High High
Peripheral Neuropathy 1 85.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it is also possible that the decrease in CD19 expression could simply reflect decreased numbers of B cells in the lungs each expressing normal levels of CD19.
Gene_expression (expression) of CD19 in lungs
1) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC3009635 Disease Relevance 0.61 Pain Relevance 0.25
Recently Sato and colleagues [56] reported that small changes in CD19 expression can induce autoantibody production and suggested that modest changes in the expression or function of regulatory molecules, such as CD19, may shift the balance between tolerance and immunity to autoimmunity [56].
Gene_expression (expression) of CD19 associated with autoimmune disease and tolerance
2) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC3009635 Disease Relevance 0.54 Pain Relevance 0.25
The induction of central tolerance with intrathymic HUVEC-injection and the immunomodulatory strategy using pristane attenuated the expression of caspase-3 as well as the expression of CD68 and CD19.


Gene_expression (expression) of CD19 associated with tolerance
3) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC3009635 Disease Relevance 0.14 Pain Relevance 0.08
However, it is also possible that the decrease in CD19 expression could simply reflect decreased numbers of B cells in the lungs each expressing normal levels of CD19.
Gene_expression (expressing) of CD19 in lungs
4) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC3009635 Disease Relevance 0.70 Pain Relevance 0.22
Here we show that in the lungs of HUVEC-injected rats, the number of B cells and the expression of cell surface CD19 is increased and that the immunomodulatory strategies attenuated this increase (Figure 3).
Gene_expression (expression) of CD19 in lungs
5) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC3009635 Disease Relevance 0.59 Pain Relevance 0.25
Anti-CD19 antibodies were from Santa Cruz Biotechnology Inc., Santa Cruz, CA, and anti-CD68 from Serotec Ltd, Oxford, UK.


Gene_expression (antibodies) of CD19
6) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC3009635 Disease Relevance 0.21 Pain Relevance 0.17
Recently Sato and colleagues [56] reported that small changes in CD19 expression can induce autoantibody production and suggested that modest changes in the expression or function of regulatory molecules, such as CD19, may shift the balance between tolerance and immunity to autoimmunity [56].
Gene_expression (expression) of CD19 associated with autoimmune disease and tolerance
7) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC3009635 Disease Relevance 0.59 Pain Relevance 0.22
In both, CSF immunophenotyping analysis identified a majority of T cells (>90%), and less than 10% of B-CLL cells expressing CD5, CD19 and CD20.
Gene_expression (expressing) of CD19 in T cells
8) Confidence 0.36 Published 2009 Journal J. Neurol. Sci. Section Abstract Doc Link 19100998 Disease Relevance 0.67 Pain Relevance 0.08
Synovial cells bearing CD3, CD4, CD8, CD19, LeuM5 (CD11c), HLA-DR, HLA-DP and CD25 antigens were measured by stereology.
Gene_expression (bearing) of CD19 in Synovial cells
9) Confidence 0.07 Published 1993 Journal J. Rheumatol. Section Body Doc Link 8164201 Disease Relevance 0.09 Pain Relevance 0
Immunophenotypic analysis by flow cytometry was performed (CD45, CD3, CD4, CD8, CD4+/CD8+ T cell ratio, CD19, CD16, CD56, CD23, CD25 and CD30 were assayed).
Gene_expression (assayed) of CD19 in T cell
10) Confidence 0.05 Published 2007 Journal Joint Bone Spine Section Body Doc Link 17387033 Disease Relevance 0.06 Pain Relevance 0
Immunohistochemistry revealed positive CD38 and negative CD20, CD19, CD56 and CD45 (Fig 2).
Neg (negative) Gene_expression (negative) of CD19
11) Confidence 0.05 Published 2008 Journal Cases J Section Body Doc Link PMC2566563 Disease Relevance 0.60 Pain Relevance 0.08

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