INT57337

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Context Info
Confidence 0.62
First Reported 1993
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.46
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DPB1) Golgi apparatus (HLA-DPB1) endoplasmic reticulum (HLA-DPB1)
plasma membrane (HLA-DPB1)
Anatomy Link Frequency
macrophages 2
microglia 2
Synovial cells 1
HLA-DPB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 3 75.00 Quite High
methotrexate 3 50.00 Quite Low
anesthesia 20 5.00 Very Low Very Low Very Low
Central nervous system 16 5.00 Very Low Very Low Very Low
ketamine 16 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glaucoma 364 90.00 High High
INFLAMMATION 1 86.20 High High
Ganglion Cysts 92 78.48 Quite High
Low Back Pain 3 75.00 Quite High
Iridocyclitis 1 69.92 Quite High
Disorder Of Lipid Metabolism 4 65.92 Quite High
Synovitis 2 50.00 Quite Low
General Immunology 1 50.00 Quite Low
Hypertension 12 36.24 Quite Low
Disease 30 16.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1 domain of DRB1, DQB1, and DPB1 gene products.
Gene_expression (products) of DPB1
1) Confidence 0.62 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0 Pain Relevance 0
Curiously, the genetically closest markers (DPA1-DPB1, 0.011 Mb; D' = 0.398) do not present the highest value of D' (DQB1-DRB1, 0.081 Mb; D' = 0.712).
Neg (not) Gene_expression (present) of DPA1-DPB1
2) Confidence 0.40 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2883542 Disease Relevance 0 Pain Relevance 0
To assess the role of HLA genes other than those encoding B27 in predisposing to JAS and AAS, we analyzed the distribution of B*4001, as well as the DRB1, DPB1, and LMP2 alleles, using PCR-based techniques in 63 JAS and 44 AAS patients (all B27 positive).
Spec (analyzed) Gene_expression (distribution) of DPB1
3) Confidence 0.31 Published 1995 Journal Hum. Immunol. Section Abstract Doc Link 8847233 Disease Relevance 0.14 Pain Relevance 0.07
Immune genes, such as TYRO protein tyrosine kinase binding protein (TYROBP), major histocompatibility complex class II DM alpha (HLA-DMA), major histocompatibility complex class II DP beta 1 (HLA-DPB1), and major histocompatibility complex class II DR alpha (HLA-DRA), were likely expressed by infiltrating mononuclear cells, resident microglia, macrophages, and possibly also astrocytes acting as non-professional antigen-presenting cells [83-86].
Gene_expression (expressed) of HLA-DPB1 in microglia
4) Confidence 0.30 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.56 Pain Relevance 0
Immune genes, such as TYRO protein tyrosine kinase binding protein (TYROBP), major histocompatibility complex class II DM alpha (HLA-DMA), major histocompatibility complex class II DP beta 1 (HLA-DPB1), and major histocompatibility complex class II DR alpha (HLA-DRA), were likely expressed by infiltrating mononuclear cells, resident microglia, macrophages, and possibly also astrocytes acting as non-professional antigen-presenting cells [83-86].
Gene_expression (expressed) of class II DP beta 1 in microglia
5) Confidence 0.26 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.56 Pain Relevance 0
Immune genes, such as TYRO protein tyrosine kinase binding protein (TYROBP), major histocompatibility complex class II DM alpha (HLA-DMA), major histocompatibility complex class II DP beta 1 (HLA-DPB1), and major histocompatibility complex class II DR alpha (HLA-DRA), were likely expressed by infiltrating mononuclear cells, resident microglia, macrophages, and possibly also astrocytes acting as non-professional antigen-presenting cells [83-86].
Gene_expression (expressed) of HLA-DPB1 in macrophages
6) Confidence 0.10 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.56 Pain Relevance 0
Immune genes, such as TYRO protein tyrosine kinase binding protein (TYROBP), major histocompatibility complex class II DM alpha (HLA-DMA), major histocompatibility complex class II DP beta 1 (HLA-DPB1), and major histocompatibility complex class II DR alpha (HLA-DRA), were likely expressed by infiltrating mononuclear cells, resident microglia, macrophages, and possibly also astrocytes acting as non-professional antigen-presenting cells [83-86].
Gene_expression (expressed) of class II DP beta 1 in macrophages
7) Confidence 0.09 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.56 Pain Relevance 0
Synovial cells bearing CD3, CD4, CD8, CD19, LeuM5 (CD11c), HLA-DR, HLA-DP and CD25 antigens were measured by stereology.
Gene_expression (bearing) of HLA-DP in Synovial cells
8) Confidence 0.02 Published 1993 Journal J. Rheumatol. Section Body Doc Link 8164201 Disease Relevance 0.09 Pain Relevance 0

General Comments

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