INT57338

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Context Info
Confidence 0.75
First Reported 1993
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 31
Total Number 33
Disease Relevance 24.62
Pain Relevance 4.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGAX) plasma membrane (ITGAX)
Anatomy Link Frequency
dendritic cells 4
CD86 4
B-cell 3
monocytes 2
neutrophils 2
ITGAX (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 526 99.86 Very High Very High Very High
cytokine 288 98.56 Very High Very High Very High
Inflammation 198 97.80 Very High Very High Very High
cINOD 12 82.72 Quite High
corticosteroid 18 81.52 Quite High
chemokine 100 77.92 Quite High
Spinal cord 7 77.28 Quite High
Inflammatory stimuli 4 77.04 Quite High
Hippocampus 3 70.40 Quite High
Nicotine 86 68.96 Quite High
Disease Link Frequency Relevance Heat
Adhesions 55 100.00 Very High Very High Very High
Rheumatoid Arthritis 532 99.86 Very High Very High Very High
B-cell Lymphoma 81 99.32 Very High Very High Very High
Follicular Lymphoma 66 99.32 Very High Very High Very High
Lymphatic System Cancer 404 99.20 Very High Very High Very High
Nicotine Addiction 59 98.92 Very High Very High Very High
Helminth Infection 32 98.92 Very High Very High Very High
Hookworm Infection 280 98.24 Very High Very High Very High
Airway Obstruction 2 98.04 Very High Very High Very High
INFLAMMATION 223 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When light chain restriction was observed, anti-CD38, FMC-7, CD79b, CD22, CD103, CD11c, CD25 expression were also investigated on B-cells to better characterize B-cell phenotype [6] and to investigate the concordance between the diagnosis reported and the phenotype of the pathological B-lymphocytes observed.
Spec (investigated) Gene_expression (expression) of CD11c in B-cells
1) Confidence 0.75 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2995803 Disease Relevance 0.66 Pain Relevance 0
On day 6, 80% or more of the nonadherent cells expressed CD11c.


Gene_expression (expressed) of CD11c
2) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714981 Disease Relevance 0.05 Pain Relevance 0.09
Co-expression of Env, CD11c and MHC-II on splenic DCs was assessed by flow cytometry 8, 15 and 35 post-infection after preparation of splenocytes from sacrificed mice.


Gene_expression (Co-expression) of CD11c associated with infection
3) Confidence 0.75 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2883599 Disease Relevance 0.10 Pain Relevance 0
Synovial cells bearing CD3, CD4, CD8, CD19, LeuM5 (CD11c), HLA-DR, HLA-DP and CD25 antigens were measured by stereology.
Gene_expression (bearing) of CD11c in Synovial cells
4) Confidence 0.65 Published 1993 Journal J. Rheumatol. Section Body Doc Link 8164201 Disease Relevance 0.09 Pain Relevance 0
Normal human monocytes, >90% CD14 and CD11c positive and less than 1% anti T cell receptor positive, were purchased from Astarte Biologics (Redmond, WA).
Gene_expression (positive) of CD11c in T cell
5) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.99 Pain Relevance 0
Data showed that injected cells expressed a dendritic cell phenotype as demonstrated by the detection of OX42 (CD11b/c), CD11c and MHC class II molecules.
Gene_expression (detection) of CD11c in dendritic cell
6) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2552991 Disease Relevance 0 Pain Relevance 0
The immunophenotype shows a mature B-cell phenotype with expression of the B-cell antigens CD11c and CD103-but unlike typical HCL the cells are CD25- and HC2-negative.
Gene_expression (expression) of CD11c in B-cell
7) Confidence 0.58 Published 2003 Journal Best Pract Res Clin Haematol Section Abstract Doc Link 12670464 Disease Relevance 0.43 Pain Relevance 0.05
In vitro, LBP has been demonstrated to induce maturation of murine bone marrow-derived dendritic cells to secrete IL-12 p40 and increase the expression of membrane markers I-A/I-E and CD11c [45].
Gene_expression (expression) of CD11c in dendritic cells
8) Confidence 0.58 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723674 Disease Relevance 1.16 Pain Relevance 0.07
The proportion of CD11c+ DCs in RA SF was higher than that of RA SF CD123+ DCs (P < 0.05).
Gene_expression (proportion) of CD11c associated with rheumatoid arthritis
9) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 1.32 Pain Relevance 0.62
Workers in our laboratory have previously shown that RA SF is enriched in CD11c+CD33brightCD14- myeloid DCs with efficient APC function [25,40].
Gene_expression (enriched) of CD11c associated with rheumatoid arthritis
10) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 1.36 Pain Relevance 0.63
Freshly isolated PB CD11c+ but not CD123+ DCs efficiently stimulated allogeneic T-cell proliferation and IFN-?
Gene_expression (isolated) of CD11c in T-cell
11) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 0.39 Pain Relevance 0.16
The percentages of CD123+CD11c- pDCs in RA PB and normal PB were low and did not differ from each other.
Gene_expression (percentages) of CD11c associated with rheumatoid arthritis
12) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 1.11 Pain Relevance 0.48
We have previously shown that the effector site in RA synovial tissue is enriched in differentiated myeloid DCs, which express CD33, CD11c, MHC and costimulatory molecules, and nuclear RelB [21,25].
Gene_expression (express) of CD11c associated with rheumatoid arthritis
13) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 1.12 Pain Relevance 0.47
To examine plasmacytoid and myeloid DCs in parallel, we compared RA SF with RA and healthy, control PB for the proportion of CD123+ and CD11c+ HLA-DR+CD14- DCs.
Gene_expression (proportion) of CD11c associated with rheumatoid arthritis
14) Confidence 0.30 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065313 Disease Relevance 1.22 Pain Relevance 0.57
Mature DCs (mDCs) from Necator americanus (Necator)–infected individuals showed an impaired differentiation process compared to the mDCs of non-infected individuals, as evidenced by the differential expression of CD11c and CD14.
Gene_expression (expression) of CD11c
15) Confidence 0.29 Published 2009 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2654967 Disease Relevance 0.56 Pain Relevance 0
Immature monocyte-derived DCs can be subsequently matured with LPS, which determines the upregulation of their antigen-presenting and co-stimulatory molecules, together with higher expression of the integrin CD11c and lack of CD14.
Gene_expression (expression) of CD11c in DCs
16) Confidence 0.29 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.34 Pain Relevance 0.03
However, here we demonstrated that hookworm ES products may be partially responsible for the alternative differentiation of DC, as observed by the reduction of CD11c and CD86 expression and increase of CD80 expression on the DC surface.
Gene_expression (expression) of CD11c in CD86 associated with hookworm infection
17) Confidence 0.29 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.48 Pain Relevance 0.12
While this is indeed the case for matured DCs from non-infected donors, mDCs from Necator-infected individuals have a down-regulated expression of antigen-presenting, costimulatory (CD86) molecules, and CD11c, with the CD14 still present on the cell surface.
Gene_expression (expression) of CD11c in CD86
18) Confidence 0.29 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.41 Pain Relevance 0.12
Monocyte-derived dendritic cells differentiated in the presence of N. americanus excreted-secreted products both from adult worm (ESAw) and L3 larvae (ESL3) showed a significant decreased expression of CD11c and CD86 while presented higher expression of CD80 (Fig 2).
Gene_expression (expression) of CD11c in CD86 associated with helminth infection
19) Confidence 0.25 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.40 Pain Relevance 0
Differentiation of the monocytes into dendritic cells in non-infected individuals occurred as expected, with a relatively higher expression of CD11c and an absence lack of CD14 (Fig. 1A).
Gene_expression (expression) of CD11c in monocytes
20) Confidence 0.22 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.20 Pain Relevance 0

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