INT57339

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Context Info
Confidence 0.49
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 7.67
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRA) Golgi apparatus (HLA-DRA) endoplasmic reticulum (HLA-DRA)
plasma membrane (HLA-DRA) lysosome (HLA-DRA)
Anatomy Link Frequency
monocytes 7
CD86 1
blood 1
macrophage 1
respiratory tract 1
HLA-DRA (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 168 99.84 Very High Very High Very High
Inflammatory response 50 97.16 Very High Very High Very High
Inflammation 159 96.96 Very High Very High Very High
anesthesia 136 96.28 Very High Very High Very High
Pain 28 87.20 High High
cytokine 79 85.16 High High
substance P 45 85.16 High High
cva 24 76.40 Quite High
Paracetamol 11 75.00 Quite High
Nerve growth factor 16 72.88 Quite High
Disease Link Frequency Relevance Heat
Endometriosis 224 99.84 Very High Very High Very High
Cancer 107 99.48 Very High Very High Very High
Lymphatic System Cancer 2 98.12 Very High Very High Very High
Sepsis 60 98.00 Very High Very High Very High
Nosocomial And Community Acquired Bacterial Infections 16 97.92 Very High Very High Very High
Hemorrhagic Shock 16 97.80 Very High Very High Very High
Burns 24 97.04 Very High Very High Very High
INFLAMMATION 188 96.96 Very High Very High Very High
Pancreatitis 32 96.80 Very High Very High Very High
Lower Respiratory Tract Infection 1 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally monocyte antigen HLA-DR was also reduced in patients with "open" cholecystectomy: in this group we also recorded 2 cases (7.6%) of respiratory tract infection.
Negative_regulation (reduced) of HLA-DR in respiratory tract associated with lower respiratory tract infection
1) Confidence 0.49 Published 1998 Journal Ann Ital Chir Section Abstract Doc Link 10052213 Disease Relevance 0.18 Pain Relevance 0.09
A recent study found downregulation of HLA-DRA in invasive cancers compared to dysplastic cervical lesions (Chil et al. 2003).
Negative_regulation (downregulation) of HLA-DRA associated with cancer
2) Confidence 0.37 Published 2007 Journal Bioinform Biol Insights Section Body Doc Link PMC2323355 Disease Relevance 0.88 Pain Relevance 0
Previous analysis performed on CD14HIGH bright and CD14LOW monocytes in patients undergoing cardiac surgery with cardiopulmonary bypass, or following low to intermediate risk surgery failed to detect a differential downregulation of HLA-DR on monocytes subsets [42,43].
Negative_regulation (downregulation) of HLA-DR in monocytes
3) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.15 Pain Relevance 0.10
The HLA-DR downregulation on the CD14LOW subset, which is increased during sepsis [29], was transient and less severe.
Negative_regulation (downregulation) of HLA-DR associated with sepsis
4) Confidence 0.24 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.26 Pain Relevance 0.08
Indeed, CAS, a less severe surgery, was associated with a lower down-regulation of HLA-DR and less frequent post-operative complications.
Negative_regulation (regulation) of HLA-DR
5) Confidence 0.24 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.37 Pain Relevance 0.16
HLA-DR on CD14HIGH monocytes started to decrease during surgery, after blood reperfusion, and was further reduced post-surgery.
Negative_regulation (decrease) of HLA-DR in blood
6) Confidence 0.24 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2887183 Disease Relevance 0.33 Pain Relevance 0.08
Deciphering the acting mediators associated with HLA-DR down-regulation on CD14HIGH and CD14LOW monocytes
Negative_regulation (regulation) of HLA-DR in monocytes
7) Confidence 0.24 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.29
Deciphering the acting mediators associated with HLA-DR down-regulation on CD14HIGH and CD14LOW monocytes
Negative_regulation (down) of HLA-DR in monocytes
8) Confidence 0.24 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.29
The degree and the duration of HLA-DR reduction on monocytes are associated with the occurrence of nosocomial infections and outcome [8-18].
Negative_regulation (reduction) of HLA-DR in monocytes associated with nosocomial and community acquired bacterial infections
9) Confidence 0.24 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.82 Pain Relevance 0.15
In accordance with these ex vivo results, HLA-DR on CD14HIGH and CD14LOW monocytes of healthy donors was reduced following incubation with hydrocortisone, whereas IL-10 only acted on CD14HIGH subpopulation.
Negative_regulation (reduced) of HLA-DR in monocytes
10) Confidence 0.24 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2887183 Disease Relevance 0.24 Pain Relevance 0.06
Following a 48 h incubation, the expression of the cell surface molecules CD86, HLA-DR and CD83 was measured by flow cytometry.
Negative_regulation (measured) of HLA-DR in CD86
11) Confidence 0.22 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3009729 Disease Relevance 0.40 Pain Relevance 0
Monocyte HLA-DR level suppression was analyzed on postoperative day 2 (Table 4; p < 0.05).
Negative_regulation (suppression) of HLA-DR in Monocyte
12) Confidence 0.14 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2667516 Disease Relevance 0.57 Pain Relevance 0
Compared to AALF-S, AALF-NS had lower monocyte HLA-DR % (11% vs. 36%, P < .001) and higher levels of IL-4, IL-6, IL-10 and TNF-alpha (P < .001).
Negative_regulation (had) of HLA-DR in monocyte
13) Confidence 0.10 Published 2006 Journal Hepatology Section Abstract Doc Link 16799971 Disease Relevance 1.24 Pain Relevance 0.28
Also CD93 (C1QR1), a cell-surface glycoprotein and part of complement component 1, was downregulated.
Negative_regulation (downregulated) of cell-surface glycoprotein
14) Confidence 0.05 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.15 Pain Relevance 0.05
Immunohistochemistry is variable, but in most cases, staining is positive for CD68, CD4, CD45, HLA-DR, and lysozyme, but negative for S100, CD20, and factor XIIIa [7].
Negative_regulation (positive) of HLA-DR
15) Confidence 0.04 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2770547 Disease Relevance 1.06 Pain Relevance 0.10
Although markers of antigen presentation on macrophages such as HLA-ABC and HLA-DR are decreased in endometriosis, macrophage-derived IL-6, IL-1?
Negative_regulation (decreased) of HLA-DR in macrophage associated with endometriosis
16) Confidence 0.04 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 0.78 Pain Relevance 0.24
RESULTS: Patients treated with MTX showed a reduction in the number of CD3+ (p = 0.01), CD4+ (p = 0.007) and HLA-DR+ (p = 0.01) cells with an improvement in the activity index (p = 0.001).
Negative_regulation (reduction) of HLA-DR
17) Confidence 0.02 Published 1993 Journal J. Rheumatol. Section Body Doc Link 8164201 Disease Relevance 0.08 Pain Relevance 0

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