INT5736

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Context Info
Confidence 0.17
First Reported 1992
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.31
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hk1) mitochondrion (Hk1) nucleus (Hk1)
carbohydrate metabolic process (Hk1) protein complex (Hk1) kinase activity (Hk1)
Anatomy Link Frequency
TK-1 1
Hk1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 1 80.12 Quite High
Inflammation 5 79.64 Quite High
positron emission tomography 24 69.12 Quite High
Calcium channel 1 60.88 Quite High
tetrodotoxin 1 55.44 Quite High
antagonist 1 47.20 Quite Low
COX2 1 25.00 Low Low
imagery 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 101 99.88 Very High Very High Very High
Drug Induced Neurotoxicity 2 96.60 Very High Very High Very High
Necrosis 3 92.32 High High
Nasopharynx Cancer 4 91.08 High High
INFLAMMATION 5 79.64 Quite High
Head & Neck Cancer 4 57.52 Quite High
Squamous Cell Neoplasms 1 50.00 Quite Low
Squamous Cell Carcinoma 2 17.04 Low Low
Carcinoma 1 5.12 Low Low
Metastasis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of VEGF, HK I, HK III, and TK-1 expression was similar for control tumors and irradiated tumors.
Gene_expression (Expression) of HK I in TK-1 associated with cancer
1) Confidence 0.17 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 1.62 Pain Relevance 0.03
Both AM and DEA produced a concentration dependent increase in intrasynaptosomal free Ca2+ concentration ([Ca2]i) to micromolar levels.
Gene_expression (produced) of DEA
2) Confidence 0.08 Published 1992 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1314962 Disease Relevance 0.18 Pain Relevance 0.09
Our results showed that while all 3 cell lines expressed the COX-2 mRNA as determined by reverse transcription-polymerise chain reaction (RT-PCR), western blot analysis showed that only HK-1 expressed the COX-2 protein.
Gene_expression (expressed) of HK-1
3) Confidence 0.08 Published 2005 Journal Biomed. Pharmacother. Section Abstract Doc Link 16507390 Disease Relevance 0.50 Pain Relevance 0.12

General Comments

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