INT57376

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Context Info
Confidence 0.69
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 12.94
Pain Relevance 4.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (EGR1) nucleus (EGR1) intracellular (EGR1)
DNA binding (EGR1) cytoplasm (EGR1)
Anatomy Link Frequency
endothelial cells 2
EGR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 15 100.00 Very High Very High Very High
Dynorphin 6 100.00 Very High Very High Very High
substance P 9 99.08 Very High Very High Very High
cINOD 38 98.98 Very High Very High Very High
Enkephalin 2 98.72 Very High Very High Very High
Osteoarthritis 88 97.90 Very High Very High Very High
rheumatoid arthritis 4 97.22 Very High Very High Very High
Hippocampus 2 97.00 Very High Very High Very High
Inflammation 169 96.96 Very High Very High Very High
anesthesia 7 87.92 High High
Disease Link Frequency Relevance Heat
Glioma 8 99.78 Very High Very High Very High
Death 86 99.48 Very High Very High Very High
INFLAMMATION 180 98.86 Very High Very High Very High
Convulsion 4 98.44 Very High Very High Very High
Apoptosis 508 98.08 Very High Very High Very High
Osteoarthritis 96 97.90 Very High Very High Very High
Rheumatoid Arthritis 4 97.22 Very High Very High Very High
Hyperglycemia 76 96.88 Very High Very High Very High
Diabetes Mellitus 173 96.68 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 13 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, gene transcription for three immediate early genes, c-fos, c-jun and NGFI-A, and three neuropeptide genes, enkephalin, dynorphin and neuropeptide Y, was investigated using nuclear run-on assays following a single injection of the convulsant pentylenetetrazole (PTZ).
Spec (investigated) Transcription (transcription) of NGFI-A associated with dynorphin, neuropeptide and enkephalin
1) Confidence 0.69 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8170346 Disease Relevance 0.17 Pain Relevance 0.44
NS-398 inhibited VEGF-induced Egr-1 mRNA and protein expression by 23+/-3% and 35+/-4%, respectively (both P<0.01).
Transcription (expression) of Egr-1
2) Confidence 0.68 Published 2001 Journal J. Physiol. Paris Section Abstract Doc Link 11595463 Disease Relevance 0.18 Pain Relevance 0.24
VEGF treatment caused a significant elevation of Egr-1 mRNA (261+/-21%, P<0.001) and protein expression (174+/-15%, P<0.01) vs. vehicle.
Transcription (expression) of Egr-1
3) Confidence 0.68 Published 2001 Journal J. Physiol. Paris Section Abstract Doc Link 11595463 Disease Relevance 0.26 Pain Relevance 0.38
The synthesis of Egr-1 in glioma cells as a result of substance P stimulation suggests that substance P exerts long-term effects in glioma cells via Egr-1-mediated gene transcription.
Transcription (transcription) of Egr-1-mediated associated with glioma and substance p
4) Confidence 0.67 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12384223 Disease Relevance 0.55 Pain Relevance 0.39
Thus, regulation of immediate early and neuropeptide gene mRNA levels and immunoreactivity occurs, at least in part, at the level of transcription for the genes encoding neuropeptide Y, dynorphin, c-fos, c-jun, and NGFI-A.
Transcription (transcription) of NGFI-A associated with dynorphin and neuropeptide
5) Confidence 0.67 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8170346 Disease Relevance 0.14 Pain Relevance 0.49
Additionally, the transcription factor early growth response-1 (Egr-1) gene was transcriptionally activated and the levels of non-steroidal anti-inflammatory drug (NSAID)-activated gene-1 (NAG-1) protein were elevated in platycodon D-treatedU937 cells.
Transcription (transcription) of Egr-1 associated with inflammation and cinod
6) Confidence 0.65 Published 2009 Journal Biomed. Pharmacother. Section Abstract Doc Link 18804340 Disease Relevance 0.95 Pain Relevance 0.18
We measured serum mRNA levels of 11 genes (MMP9, CRP, HMGB1, MUC1, EGR1, PBEF1, PDGFA, TGF-?
Transcription (levels) of EGR1
7) Confidence 0.59 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.36 Pain Relevance 0.49
Isochaihulactone increased EGR-1 and then NAG-1 mRNA and protein expression.
Transcription (expression) of EGR-1
8) Confidence 0.59 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17715378 Disease Relevance 0.64 Pain Relevance 0.17
Additionally, the transcription factor early growth response-1 (Egr-1) gene was transcriptionally activated and the levels of non-steroidal anti-inflammatory drug (NSAID)-activated gene-1 (NAG-1) protein were elevated in platycodon D-treatedU937 cells.
Transcription (transcription) of factor early growth response-1 associated with inflammation and cinod
9) Confidence 0.57 Published 2009 Journal Biomed. Pharmacother. Section Abstract Doc Link 18804340 Disease Relevance 0.95 Pain Relevance 0.18
The 27 upregulated genes encoded seven transcription factors (JUN, EGR1, JUNB, FOS, FOSB, MYCN, and SNAIL1), four of which are components of the AP-1 transcription factor family (JUN, JUNB, FOS, and FOSB).
Transcription (transcription) of EGR1
10) Confidence 0.57 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.12 Pain Relevance 0.09
IND pre-treatment significantly inhibited VEGF-induced Egr-1 mRNA expression by 29+/-4% (P<0.01) and protein expression by 41+/-8% (P<0.05).
Transcription (expression) of Egr-1
11) Confidence 0.52 Published 2001 Journal J. Physiol. Paris Section Abstract Doc Link 11595463 Disease Relevance 0.24 Pain Relevance 0.37
Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene.
Transcription (Transcriptional) of early growth response-1
12) Confidence 0.52 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 16079301 Disease Relevance 0.28 Pain Relevance 0.10
The potential arsenic biomarker set is composed of transcripts for the CXL1, DUSP1, EGR-1, IER2, JUNB, MIRN21, OSM, PTGS2, RNF149, SFRS5, and SOC3 genes (Table 1).
Transcription (transcripts) of EGR-1
13) Confidence 0.49 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC2082467 Disease Relevance 0 Pain Relevance 0
It has been shown that mPGES-1 expression is upregulated in animal models of rheumatoid arthritis and in patients suffering from OA [4,5] and is downregulated by anti-inflammatory drugs [6,7]. mPGES-1 expression is regulated by several transcription factors, such as early growth response-1 (Egr-1) and NF-?
Transcription (transcription) of early growth response-1 associated with inflammation, cinod, rheumatoid arthritis and osteoarthritis
14) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.95 Pain Relevance 0.60
It has been shown that mPGES-1 expression is upregulated in animal models of rheumatoid arthritis and in patients suffering from OA [4,5] and is downregulated by anti-inflammatory drugs [6,7]. mPGES-1 expression is regulated by several transcription factors, such as early growth response-1 (Egr-1) and NF-?
Transcription (transcription) of Egr-1 associated with inflammation, cinod, rheumatoid arthritis and osteoarthritis
15) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.95 Pain Relevance 0.60
Among these were transcription factors such as activating transcription factor 4 (ATF4) and early growth response 1 (EGR1) (Table 2).
Transcription (transcription) of early growth response 1
16) Confidence 0.44 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.21 Pain Relevance 0
Among these were transcription factors such as activating transcription factor 4 (ATF4) and early growth response 1 (EGR1) (Table 2).
Transcription (transcription) of EGR1
17) Confidence 0.44 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.21 Pain Relevance 0
A possible explanation for these results is the upregulation of the transcription factor early growth response protein 1 (Egr-1), which in turn downregulates TRAIL expression in endothelial cells, by both hyperglycemia and insulin.
Transcription (transcription) of Egr-1 in endothelial cells associated with hyperglycemia
18) Confidence 0.19 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.08 Pain Relevance 0.06
early growth response-1 (EGR-1) transcription factor.
Transcription (transcription) of early growth response-1
19) Confidence 0.19 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.31 Pain Relevance 0
A possible explanation for these results is the upregulation of the transcription factor early growth response protein 1 (Egr-1), which in turn downregulates TRAIL expression in endothelial cells, by both hyperglycemia and insulin.
Transcription (transcription) of factor early growth response protein 1 in endothelial cells associated with hyperglycemia
20) Confidence 0.17 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.08 Pain Relevance 0.06

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