INT57378

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Context Info
Confidence 0.57
First Reported 1994
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Pura) cell proliferation (Pura) nucleus (Pura)
DNA binding (Pura) transcription factor binding (Pura) cytoplasm (Pura)
Anatomy Link Frequency
cerebellum 2
Pura (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 17 99.60 Very High Very High Very High
withdrawal 2 93.68 High High
tolerance 4 86.88 High High
addiction 4 85.76 High High
opiate 2 75.72 Quite High
Neuropeptide 1 62.56 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activity of single-stranded CRE binding proteins (ssCRE-BP) was decreased by chronic morphine treatment to about 40% of control in the cerebellum.
Negative_regulation (decreased) of ssCRE-BP in cerebellum associated with morphine
1) Confidence 0.57 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8170350 Disease Relevance 0 Pain Relevance 0.92
The activity of ssCRE-BP was also decreased by acute morphine treatment in 5 h, but it returned to control level in 24 h.
Negative_regulation (decreased) of ssCRE-BP associated with morphine
2) Confidence 0.57 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8170350 Disease Relevance 0 Pain Relevance 0.95
We have reported that the DNA-binding activity of a single stranded cyclic AMP response element-binding protein (ssCRE-BP) is suppressed in cerebellum treated chronically with morphine, ssCRE-BP is identical to Pur alpha and the DNA binding activity of Pur alpha is markedly enhanced by a heat stable activator in the nuclear extract.
Negative_regulation (suppressed) of ssCRE-BP in cerebellum associated with morphine
3) Confidence 0.06 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10049721 Disease Relevance 0 Pain Relevance 0.13

General Comments

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