INT57379

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Context Info
Confidence 0.69
First Reported 1994
Last Reported 2010
Negated 2
Speculated 7
Reported most in Abstract
Documents 79
Total Number 86
Disease Relevance 28.24
Pain Relevance 30.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
hippocampus 12
brain 8
neurons 8
neuronal 6
amygdala 5
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 521 100.00 Very High Very High Very High
long-term potentiation 448 100.00 Very High Very High Very High
Morphine 95 100.00 Very High Very High Very High
Calcitonin gene-related peptide 18 100.00 Very High Very High Very High
Opioid 30 99.84 Very High Very High Very High
Dorsal horn neuron 10 99.84 Very High Very High Very High
fluoxetine 123 99.82 Very High Very High Very High
antidepressant 1016 99.70 Very High Very High Very High
Spinal cord 148 99.68 Very High Very High Very High
peripheral neuropathy 1 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1341 100.00 Very High Very High Very High
Death 16 99.78 Very High Very High Very High
Targeted Disruption 810 99.72 Very High Very High Very High
Peripheral Neuropathy 1 99.54 Very High Very High Very High
Drug Dependence 48 99.52 Very High Very High Very High
Neurodegenerative Disease 103 99.48 Very High Very High Very High
Insulin Resistance 168 99.08 Very High Very High Very High
Alzheimer's Dementia 77 99.00 Very High Very High Very High
Congenital Anomalies 30 98.60 Very High Very High Very High
Anxiety Disorder 551 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They could all significantly stimulate CREB phosphorylation and maintained for a long time without affecting total CREB protein levels.
Positive_regulation (stimulate) of Phosphorylation (phosphorylation) of CREB
1) Confidence 0.69 Published 2003 Journal Cell Res. Section Abstract Doc Link 12643347 Disease Relevance 0 Pain Relevance 0.57
We also examined the effects of ketamine, a noncompetitive N-mthyl-D-aspartate receptor (NR) antagonist, on morphine-, F9202- and F9204- induced CPP and phosphorylation of CREB in hippocampus.
Spec (examined) Positive_regulation (induced) of Phosphorylation (phosphorylation) of CREB in hippocampus associated with ketamine, antagonist, hippocampus and morphine
2) Confidence 0.69 Published 2003 Journal Cell Res. Section Abstract Doc Link 12643347 Disease Relevance 0 Pain Relevance 0.90
As one important endocrine stress response is the activation of the adrenergic system[4], most likely the protein kinase A predominantly is involved in stress-induced CREB phosphorylation.
Positive_regulation (-) of Phosphorylation (phosphorylation) of CREB associated with stress
3) Confidence 0.69 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.73 Pain Relevance 0.17
As CBP is a crucial cofactor in mediating phosphorylation-dependent CREB activity, enhanced levels of CBP might reflect increased CREB phosphorylation.
Spec (might) Positive_regulation (increased) of Phosphorylation (phosphorylation) of CREB
4) Confidence 0.69 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.63 Pain Relevance 0.14
CREB phosphorylation likewise was significantly enhanced in pons and hippocampus and with a strong tendency in the colliculi, which indicates an enhanced signalling cascade leading to kinase activation in these regions.
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of CREB in pons associated with hippocampus
5) Confidence 0.69 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.72 Pain Relevance 0.23
To examine whether imipramine also has an effect on the stress-induced phosphorylation of CREB we determined CREB phosphorylation in mice subjected to chronic stress plus imipramine treatment.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of CREB associated with stress
6) Confidence 0.69 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.72 Pain Relevance 0.07
This supports the notion that for comprehensive characterization of an effect on CREB activity it is not sufficient to determine only phosphorylation of CREB but rather its impact on gene expression.
Neg (not) Positive_regulation (sufficient) of Spec (determine) Phosphorylation (phosphorylation) of CREB
7) Confidence 0.69 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.18 Pain Relevance 0
KN-62 (10 microM), an inhibitor of CaM kinases, prevented CREB phosphorylation induced by morphine, F9202, and F9204 without change of total CREB level.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of CREB associated with morphine
8) Confidence 0.68 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0 Pain Relevance 0.71
The CREB phosphorylation of cultured hippocampal neurons was also enhanced and reached its peak level at 30 min upon exposure to F9202 (100 nM), F9204 (100 nM) or morphine (1 microM), while the total CREB protein level was not altered.
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of CREB in neurons associated with morphine
9) Confidence 0.68 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0 Pain Relevance 0.73
F9203, which could not induce CPP, failed to increase the CREB phosphorylation and the colocalization of P-CREB with CaMKIV both in hippocampus from CPP mice and in cultured hippocampal neurons.
Neg (failed) Positive_regulation (increase) of Phosphorylation (phosphorylation) of CREB in neurons associated with hippocampus
10) Confidence 0.68 Published 2004 Journal Brain Res. Section Abstract Doc Link 15451364 Disease Relevance 0 Pain Relevance 0.58
Our findings suggest that constitutively active CREB phosphorylation is important for the survival of mammalian cells in the brain.



Positive_regulation (important) of Phosphorylation (phosphorylation) of CREB in brain
11) Confidence 0.68 Published 2006 Journal Mol Pain Section Abstract Doc Link PMC1459854 Disease Relevance 0 Pain Relevance 0.04
Our findings suggest that constitutively active CREB phosphorylation is important for the survival of mammalian cells in the brain.



Positive_regulation (active) of Phosphorylation (phosphorylation) of CREB in brain
12) Confidence 0.68 Published 2006 Journal Mol Pain Section Abstract Doc Link PMC1459854 Disease Relevance 0 Pain Relevance 0.04
Such data suggest that immediately following drug intake, upregulation in accumbal CREB (or increased phosphorylation of CREB) may diminish the salience of further drug administration.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of CREB
13) Confidence 0.68 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.33 Pain Relevance 0.29
Additionally, NAN-190 decreased and 8-OH-DPAT increased phosphorylated cAMP response element-binding protein (CREB) levels in WT mice but not in KO mice.
Positive_regulation (increased) of Phosphorylation (phosphorylated) of CREB
14) Confidence 0.61 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20164327 Disease Relevance 0.61 Pain Relevance 0.35
Meanwhile, AQP4 knockout abolished fluoxetine-induced enhancement of hippocampal cyclic AMP-responsive element binding protein (CREB) phosphorylation.
Positive_regulation (enhancement) of Phosphorylation (phosphorylation) of CREB associated with targeted disruption and fluoxetine
15) Confidence 0.58 Published 2009 Journal Neuropsychopharmacology Section Abstract Doc Link 18923397 Disease Relevance 1.37 Pain Relevance 0.59
CGRP activated Ca(2+)-calmodulin-dependent kinase II, which became localized to the perimembrane region and neuronal processes, a phenomenon already apparent after 30 min and accompanied by a parallel increase in cAMP-response element-binding protein (CREB) phosphorylation and nuclear translocation.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of CREB in neuronal associated with calcitonin gene-related peptide
16) Confidence 0.55 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18460469 Disease Relevance 0.43 Pain Relevance 0.61
The combination of both compounds augmented CREB phosphorylation, but their effect was suppressed by BHA (a scavenger of free radicals) and MnTBAP (an SOD mimetic material) (Fig. 6A).
Positive_regulation (augmented) of Phosphorylation (phosphorylation) of CREB
17) Confidence 0.53 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.06 Pain Relevance 0
The increased phosphorylation of CREB was restored by AdSOD1.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of CREB
18) Confidence 0.53 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.10 Pain Relevance 0
Consequently, the 90% reduction of CREB in CREBalphaDelta mutant mice differentially affects CREB phosphorylation and induction of downstream targets of CREB in the NAc and VTA.
Positive_regulation (induction) of Phosphorylation (phosphorylation) of CREB in NAc associated with ventral tegmentum and nucleus accumbens
19) Confidence 0.50 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 14622103 Disease Relevance 0 Pain Relevance 0.70
In our study the most pronounced effect of imipramine was seen only in combination with chronic psychosocial stress where it exerts a reversal of the stress-induced CREB phsophorylation and activation.
Positive_regulation (induced) of Phosphorylation (phsophorylation) of CREB associated with stress
20) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.62 Pain Relevance 0.66

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