INT57380

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Context Info
Confidence 0.82
First Reported 1994
Last Reported 2010
Negated 0
Speculated 5
Reported most in Abstract
Documents 213
Total Number 218
Disease Relevance 66.80
Pain Relevance 71.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
hippocampus 17
neurons 15
brain 8
neuronal 7
striatum 5
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 557 100.00 Very High Very High Very High
Morphine 342 100.00 Very High Very High Very High
adenocard 23 100.00 Very High Very High Very High
Spinal cord 281 99.92 Very High Very High Very High
Calcitonin gene-related peptide 22 99.90 Very High Very High Very High
Hippocampus 1151 99.84 Very High Very High Very High
Dorsal horn neuron 14 99.84 Very High Very High Very High
Inflammation 258 99.72 Very High Very High Very High
Pain 253 99.72 Very High Very High Very High
Nucleus accumbens 329 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 3008 100.00 Very High Very High Very High
Drug Dependence 124 100.00 Very High Very High Very High
Urological Neuroanatomy 67 99.84 Very High Very High Very High
Disease 848 99.56 Very High Very High Very High
Neurodegenerative Disease 279 99.48 Very High Very High Very High
INFLAMMATION 199 99.44 Very High Very High Very High
Alzheimer's Dementia 198 99.44 Very High Very High Very High
Peripheral Neuropathy 1 99.34 Very High Very High Very High
Death 83 99.32 Very High Very High Very High
Insulin Resistance 551 99.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consequently, the 90% reduction of CREB in CREBalphaDelta mutant mice differentially affects CREB phosphorylation and induction of downstream targets of CREB in the NAc and VTA.
Phosphorylation (phosphorylation) of CREB in NAc associated with ventral tegmentum and nucleus accumbens
1) Confidence 0.82 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 14622103 Disease Relevance 0 Pain Relevance 0.70
As indicated by Western blots, the changes in CRE/CREB-directed transcription were accompanied by corresponding changes in the phosphorylation of CREB at serine-119.
Phosphorylation (phosphorylation) of CREB
2) Confidence 0.82 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20122921 Disease Relevance 0.45 Pain Relevance 0.64
We also examined the effects of ketamine, a noncompetitive N-mthyl-D-aspartate receptor (NR) antagonist, on morphine-, F9202- and F9204- induced CPP and phosphorylation of CREB in hippocampus.
Phosphorylation (phosphorylation) of CREB in hippocampus associated with ketamine, antagonist, hippocampus and morphine
3) Confidence 0.82 Published 2003 Journal Cell Res. Section Abstract Doc Link 12643347 Disease Relevance 0 Pain Relevance 0.90
These findings suggest that alterations in the phosphorylation of CREB be relevant to opiates signaling and the development of opiates dependence.
Phosphorylation (phosphorylation) of CREB associated with addiction and opiate
4) Confidence 0.82 Published 2003 Journal Cell Res. Section Abstract Doc Link 12643347 Disease Relevance 0 Pain Relevance 0.95
Ohmefentanyl stereoisomers induce changes of CREB phosphorylation in hippocampus of mice in conditioned place preference paradigm.
Phosphorylation (phosphorylation) of CREB in hippocampus associated with analgesic and hippocampus
5) Confidence 0.82 Published 2003 Journal Cell Res. Section Title Doc Link 12643347 Disease Relevance 0 Pain Relevance 0.90
Ketamine could suppress not only the place preference but also the phosphorylation of CREB produced by morphine, F9202 and F9204.
Phosphorylation (phosphorylation) of CREB associated with ketamine and morphine
6) Confidence 0.82 Published 2003 Journal Cell Res. Section Abstract Doc Link 12643347 Disease Relevance 0 Pain Relevance 0.93
They could all significantly stimulate CREB phosphorylation and maintained for a long time without affecting total CREB protein levels.
Phosphorylation (phosphorylation) of CREB
7) Confidence 0.82 Published 2003 Journal Cell Res. Section Abstract Doc Link 12643347 Disease Relevance 0 Pain Relevance 0.57
The present study was designed to determine the changes of phosphorylation of cAMP- response element binding protein (CREB) in hippocampus induced by ohmefentanyl stereoisomers (F9202 and F9204) in conditioned place preference (CPP) paradigm.
Phosphorylation (phosphorylation) of CREB in hippocampus associated with hippocampus
8) Confidence 0.82 Published 2003 Journal Cell Res. Section Abstract Doc Link 12643347 Disease Relevance 0 Pain Relevance 0.33
Chronic morphine administration induces over-expression of aldolase C with reduction of CREB phosphorylation in the mouse hippocampus.
Phosphorylation (phosphorylation) of CREB in hippocampus associated with narcan, hippocampus and morphine
9) Confidence 0.82 Published 2009 Journal Eur. J. Pharmacol. Section Title Doc Link 19289113 Disease Relevance 0.21 Pain Relevance 0.94
The results suggest potential links between the morphine-induced alteration of aldolase C and the regulation of CREB phosphorylation, a possible mechanism of morphine dependence.
Phosphorylation (phosphorylation) of CREB associated with addiction and morphine
10) Confidence 0.82 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19289113 Disease Relevance 0.25 Pain Relevance 0.93
When detecting the expression of phosphorylated CREB (p-CREB) in the mouse hippocampus using Western blot and immunohistochemistry, we found CREB phosphorylation was clearly decreased following chronic morphine treatment.
Phosphorylation (phosphorylation) of CREB in hippocampus associated with hippocampus and morphine
11) Confidence 0.82 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19289113 Disease Relevance 0.24 Pain Relevance 1.16
Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala.
Phosphorylation (phosphorylated) of CREB in amygdala associated with anxiety disorder and amygdala
12) Confidence 0.82 Published 2004 Journal Neuropsychopharmacology Section Title Doc Link 14583739 Disease Relevance 0.51 Pain Relevance 0.27
In the past, several studies tried to determine the role of CREB in antidepressant action the majority of which reported on CREB phosphorylation as an indicator for its transcriptional activity[15].
Phosphorylation (phosphorylation) of CREB associated with antidepressant
13) Confidence 0.81 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.07 Pain Relevance 0.16
Therefore CRE/CREB-directed regulation of gene transcription cannot be determined by measuring simply CREB phosphorylation but rather by determining expression of a CRE/CREB-driven gene product which requires the generation of transgenic animals carrying a reporter gene.
Phosphorylation (phosphorylation) of CREB associated with targeted disruption
14) Confidence 0.81 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.28 Pain Relevance 0.16
As CBP is a crucial cofactor in mediating phosphorylation-dependent CREB activity, enhanced levels of CBP might reflect increased CREB phosphorylation.
Phosphorylation (phosphorylation) of CREB
15) Confidence 0.81 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.63 Pain Relevance 0.14
The basal CREB phosphorylation did not correlate with the luciferase activity.
Phosphorylation (phosphorylation) of CREB
16) Confidence 0.81 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.07 Pain Relevance 0.19
CREB phosphorylation likewise was significantly enhanced in pons and hippocampus and with a strong tendency in the colliculi, which indicates an enhanced signalling cascade leading to kinase activation in these regions.
Phosphorylation (phosphorylation) of CREB in pons associated with hippocampus
17) Confidence 0.81 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.71 Pain Relevance 0.22
As TORC confers CREB activity independent of phosphorylation on Ser-133, the discrepancy between phosphorylation and activity of CREB could be explained, at least for the hippocampus, by the involvement of TORC.
Phosphorylation (phosphorylation) of CREB in hippocampus associated with hippocampus
18) Confidence 0.81 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.21 Pain Relevance 0.21
As one important endocrine stress response is the activation of the adrenergic system[4], most likely the protein kinase A predominantly is involved in stress-induced CREB phosphorylation.
Phosphorylation (phosphorylation) of CREB associated with stress
19) Confidence 0.81 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.73 Pain Relevance 0.17
As TORC confers CREB activity independent of phosphorylation on Ser-133, the discrepancy between phosphorylation and activity of CREB could be explained, at least for the hippocampus, by the involvement of TORC.
Phosphorylation (phosphorylation) of CREB in hippocampus associated with hippocampus
20) Confidence 0.81 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.27 Pain Relevance 0.21

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