INT57389

Context Info Confidence 0.45 First Reported 1993 Last Reported 1998 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.28 Pain Relevance 0.78

transport (ARL4C) plasma membrane (ARL4C) nucleus (ARL4C) intracellular (ARL4C) GTPase activity (ARL4C) cytoplasm (ARL4C)

Anatomy Link Frequency LAK cell 2 ARL4C (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 8 98.54 aspirin 3 86.80 cytokine 2 84.36 Inflammation 1 72.28

Disease Link Frequency Relevance Heat INFLAMMATION 4 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results indicated that PGE2 suppression may not be the only mechanism of indomethacin for upregulation of LAK cell activity, and even immune functions.

Positive_regulation (upregulation) of LAK in LAK cell

1) Confidence 0.45 Published 1993 Journal Proc. Natl. Sci. Counc. Repub. China B Section Abstract Doc Link 8171164 Disease Relevance 0.06 Pain Relevance 0.14

These two NSAIDs augmented proliferation of phytohemagglutinin (PHA)-stimulated PBMC and enhanced NK and LAK cell activities.

Positive_regulation (enhanced) of LAK in LAK cell associated with cinod

2) Confidence 0.45 Published 1998 Journal Immunopharmacology Section Abstract Doc Link 9858064 Disease Relevance 0.22 Pain Relevance 0.63

General Comments

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