INT57397

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Context Info
Confidence 0.28
First Reported 1994
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 4.06
Pain Relevance 3.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aif1) cytoplasm (Aif1)
Anatomy Link Frequency
microglia 4
macrophages 2
area postrema 1
spinal 1
spinal cords 1
Aif1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Percutaneous transluminal coronary angioplasty 4 100.00 Very High Very High Very High
trigeminal ganglion 40 99.42 Very High Very High Very High
allodynia 99 98.58 Very High Very High Very High
Spinal cord 128 98.18 Very High Very High Very High
ischemia 63 97.96 Very High Very High Very High
Pain 190 97.44 Very High Very High Very High
Inflammation 170 96.16 Very High Very High Very High
Snapping jaw 42 95.64 Very High Very High Very High
Neuropathic pain 53 95.12 Very High Very High Very High
medulla 63 94.04 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 44 99.42 Very High Very High Very High
Neuropathic Pain 193 98.58 Very High Very High Very High
Cv Unclassified Under Development 51 97.96 Very High Very High Very High
Myocardial Infarction 4 97.64 Very High Very High Very High
Pain 219 97.44 Very High Very High Very High
INFLAMMATION 200 96.16 Very High Very High Very High
Nervous System Injury 143 95.76 Very High Very High Very High
Temporomandibular Joint Syndrome 42 95.64 Very High Very High Very High
Apoptosis 14 91.04 High High
Adhesions 2 85.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
m-thick sections were examined by immunostaining for microtubule-associated protein 2 (MAP2), IBA-1 and glial fibrillary acidic protein (GFAP).
IBA-1 Spec (examined) Binding (immunostaining) of
1) Confidence 0.28 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2949765 Disease Relevance 0.21 Pain Relevance 0.24
After intrathecal injection of ketamine at P3, 7, or 21, spinal cords were examined for apoptosis (Fluoro-Jade C and activated caspase-3), histopathologic change, and glial responses (ionized calcium-binding adapter molecule 1 and glial fibrillary acid protein).
adapter molecule 1 Binding (binding) of in spinal cords
2) Confidence 0.26 Published 2010 Journal Anesthesiology Section Body Doc Link 20526188 Disease Relevance 0.08 Pain Relevance 0
Surprisingly, in any of the three divisions of the ipsilateral TG no changes in the number of Iba1+ resident macrophages and no difference in their mean cell size were observed at either 24 h or 72 h following CFA injection (see Figure 3, panels A-B' for representative images of Iba1 staining, and panels C-E and F-H for quantification of Iba1 cell number and of their average cell size, respectively).
Iba1 Binding (macrophages) of in macrophages associated with trigeminal ganglion
3) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017032 Disease Relevance 0.57 Pain Relevance 0.36
Although TUNEL-positive cells were present throughout the gray and white matter at this stage, they were virtually all labeled with antibody against ionized calcium-binding adapter molecule 1, a marker for microglia.
adapter molecule 1 Binding (binding) of in microglia
4) Confidence 0.25 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16014727 Disease Relevance 0.99 Pain Relevance 0.58
Expression of TNF-alpha and GFAP in bilateral L5 DRGs and expression of GFAP and ionized calcium-binding adaptor molecule-1 (Iba-1) in bilateral L5 spinal dorsal horns were studied using immunohistochemistry and immunoblotting.
Iba-1 Binding (binding) of in spinal
5) Confidence 0.23 Published 2008 Journal Spine Section Body Doc Link 18496347 Disease Relevance 0.11 Pain Relevance 0
Spinal cord sections were immunostained with antibodies against markers of microglia, ionized calcium binding adaptor molecule 1 (Iba1, polyclonal antibody rabbit anti-Iba1, 1?
Iba1 Binding (binding) of in microglia associated with spinal cord
6) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2966439 Disease Relevance 0 Pain Relevance 0.15
Spinal cord sections were immunostained with antibodies against markers of microglia, ionized calcium binding adaptor molecule 1 (Iba1, polyclonal antibody rabbit anti-Iba1, 1?
Iba1 Binding (binding) of in microglia associated with spinal cord
7) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2966439 Disease Relevance 0 Pain Relevance 0.15
g/ml of the primary antibody rabbit anti-Ionized calcium binding adapter molecule-1 (anti-Iba-1, Wako, Richmond, VA, USA) [22].
anti-Iba-1 Binding (binding) of
8) Confidence 0.16 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.09 Pain Relevance 0.09
Unfortunately, many studies defined microglial activation only based on altered expression of Iba1 or OX-42 (CD11b), which lead to controversies when trying to link microglial activation and pain states, because the direct role of Iba1 and CD11b in neuropathic pain genesis is unclear.
Iba1 Spec (unclear) Binding (lead) of associated with pain and neuropathic pain
9) Confidence 0.16 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759920 Disease Relevance 0.99 Pain Relevance 0.85
Five hours following LPS injection, at a time where an acute mechanical allodynia was detected in the lower lip, we found some morphological changes of Iba-1+ microglia in the CVOs, such as area postrema (AP) where the soma of these Iba-1+ cells started to enlarge, and displayed thick and rigid processes (Figure 5, mid-column).
Iba-1 Binding (microglia) of in area postrema associated with allodynia
10) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992508 Disease Relevance 0.61 Pain Relevance 0.39
10,000, Dako Cytomation, Glostrup, Denmark) except when co-staining with Iba-1.
Iba-1 Binding (staining) of
11) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0 Pain Relevance 0.03
The choice of label was based on staining clarity, which depended on the tissue and cell activation state, and on compatibility; i.e., polyclonal rabbit Iba-1 and SK3 antibodies could not be combined.
Iba-1 Binding (combined) of
12) Confidence 0.04 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819255 Disease Relevance 0 Pain Relevance 0
1000 dilution, Product ID G3893, Sigma-Aldrich, MO, USA) and anti-ionized calcium-binding adaptor molecule 1 (Iba-1) rabbit polyclonal antibody (1?
Iba-1 Binding (binding) of
13) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424136 Disease Relevance 0 Pain Relevance 0.03
Iba-1 is a calcium-binding protein that is restrictedly expressed in macrophages/microglia [18].
Iba-1 Binding (binding) of in microglia
14) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864748 Disease Relevance 0 Pain Relevance 0.07
The delayed onset may reflect certain pharmacokinetics associated with IBA or its cognate receptor.
IBA Binding (associated) of
15) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2831077 Disease Relevance 0.06 Pain Relevance 0.31
Iba-1 is a calcium-binding protein that is restrictedly expressed in macrophages/microglia [18].
Iba-1 Binding (binding) of in macrophages
16) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864748 Disease Relevance 0 Pain Relevance 0.07
Direct percutaneous transluminal coronary angioplasty (PTCA) is a recognized alternative to intravenous thrombolytic therapy for early acute myocardial infarction (AMI).
angioplasty Binding (recognized) of associated with myocardial infarction and percutaneous transluminal coronary angioplasty
17) Confidence 0.00 Published 1994 Journal Am. Heart J. Section Abstract Doc Link 8172049 Disease Relevance 0.36 Pain Relevance 0.14

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