INT57424

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Context Info
Confidence 0.67
First Reported 1994
Last Reported 2010
Negated 4
Speculated 0
Reported most in Abstract
Documents 42
Total Number 42
Disease Relevance 31.84
Pain Relevance 9.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNNT1)
Anatomy Link Frequency
chest 3
anterior 1
platelet 1
autonomic 1
myocyte 1
TNNT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 132 99.90 Very High Very High Very High
ischemia 88 98.80 Very High Very High Very High
Inflammatory marker 25 97.44 Very High Very High Very High
depression 9 95.16 Very High Very High Very High
Catecholamine 141 94.44 High High
cva 33 92.64 High High
Pain 19 91.40 High High
antagonist 1 91.20 High High
aspirin 29 90.20 High High
beta blocker 20 89.68 High High
Disease Link Frequency Relevance Heat
Death 36 99.92 Very High Very High Very High
Angina 48 99.90 Very High Very High Very High
Cv General 3 Under Development 95 99.84 Very High Very High Very High
Coronary Heart Disease 39 99.76 Very High Very High Very High
Thrombocytosis 10 99.70 Very High Very High Very High
Myocardial Infarction 258 99.68 Very High Very High Very High
Syndrome 15 99.62 Very High Very High Very High
Necrosis 61 99.46 Very High Very High Very High
Acute Coronary Syndrome 180 99.40 Very High Very High Very High
Cv Unclassified Under Development 56 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The troponin T level increases about 4 to 6 hours after the first myocardial damage.
Positive_regulation (increases) of troponin T
1) Confidence 0.67 Published 2010 Journal GMS German Medical Science Section Body Doc Link PMC2975259 Disease Relevance 1.30 Pain Relevance 0.36
Initial perfusion defect size correlated strongly with increased troponin T at 96 hours (r = 0.73, p <0.001) and with ejection fraction at 4 weeks of follow-up (r = -0.79, p <0.001).
Positive_regulation (increased) of troponin T
2) Confidence 0.67 Published 2004 Journal Am. J. Cardiol. Section Abstract Doc Link 15541235 Disease Relevance 0.83 Pain Relevance 0.33
MCE identified all 6 patients who had non-ST-elevation myocardial infarction and no initial increase in troponin T and 17 of 19 patients who had non-ST-elevation myocardial infarction and an initial increase in troponin T.
Neg (no) Positive_regulation (increase) of troponin T associated with myocardial infarction
3) Confidence 0.67 Published 2004 Journal Am. J. Cardiol. Section Abstract Doc Link 15541235 Disease Relevance 1.12 Pain Relevance 0.37
MCE identified all 6 patients who had non-ST-elevation myocardial infarction and no initial increase in troponin T and 17 of 19 patients who had non-ST-elevation myocardial infarction and an initial increase in troponin T.
Positive_regulation (increase) of troponin T associated with myocardial infarction
4) Confidence 0.67 Published 2004 Journal Am. J. Cardiol. Section Abstract Doc Link 15541235 Disease Relevance 1.11 Pain Relevance 0.37
RESULTS: The risk of in-hospital and long-term mortality increased with absolute levels of troponin T.
Positive_regulation (increased) of troponin T
5) Confidence 0.67 Published 2004 Journal Am. J. Med. Section Body Doc Link 15629727 Disease Relevance 0.15 Pain Relevance 0
Cardiac troponin T and CKMB were only elevated in 33.8% and 55.0% of these patients, respectively.
Positive_regulation (elevated) of troponin T
6) Confidence 0.67 Published 2005 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 16309372 Disease Relevance 0.70 Pain Relevance 0.36
But the level of CK-MB and Troponin T were increased up to 77.54 ng/ml and 1.62 ng/ml, respectively.
Positive_regulation (increased) of Troponin T
7) Confidence 0.67 Published 2007 Journal Int. J. Cardiol. Section Abstract Doc Link 17097166 Disease Relevance 0.93 Pain Relevance 0.23
The prevalence of elevated serum troponin T was determined and its diagnostic value in acute coronary syndrome was assessed in patients with chronic renal insufficiency.
Positive_regulation (elevated) of troponin T associated with acute coronary syndrome and chronic renal insufficiency
8) Confidence 0.67 Published 2008 Journal Asian Cardiovasc Thorac Ann Section Abstract Doc Link 18670019 Disease Relevance 0.78 Pain Relevance 0.08
Persistently elevated CKMB and negative troponin T in a patient at ischaemic risk with chest pain.
Positive_regulation (elevated) of troponin T in chest associated with angina
9) Confidence 0.67 Published 2010 Journal Cardiovasc J Afr Section Title Doc Link 20224846 Disease Relevance 0.19 Pain Relevance 0.19
These observations were compatible with the absence of ischemic or necrosis areas by EKG, in spite of elevated troponin T levels.
Positive_regulation (elevated) of troponin T associated with necrosis
10) Confidence 0.67 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1434771 Disease Relevance 1.05 Pain Relevance 0.04
However, we observed an inverse association of troponin T and systolic pressure, a positive association with diastolic pressure and mean blood pressure variations, suggesting that pressure instability contributed to elevation of troponin T in these patients.
Positive_regulation (elevation) of troponin T in blood
11) Confidence 0.67 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1434771 Disease Relevance 0.86 Pain Relevance 0.06
Elevated troponin-T and NT-proBNP confirmed significant ventricular injury in these animals compared to all other groups.
Positive_regulation (Elevated) of troponin-T associated with injury
12) Confidence 0.67 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994378 Disease Relevance 0.83 Pain Relevance 0.19
g/kg), selectively delivered before first balloon inflation via an intracoronary catheter with the tip distal to the coronary lesion, significantly reduced the incidence of CK-MB elevation and troponin-T elevation after PCI and improve short-term clinical outcomes, compared to placebo [75].
Positive_regulation (elevation) of troponin-T
13) Confidence 0.67 Published 2008 Journal Current Cardiology Reviews Section Body Doc Link PMC2780824 Disease Relevance 0.15 Pain Relevance 0.29
Laboratory studies (Table 1) showed an elevated platelet count (708 G/L) and increased troponin-T levels.
Positive_regulation (increased) of troponin-T in platelet associated with thrombocytosis
14) Confidence 0.67 Published 2010 Journal Thromb J Section Body Doc Link PMC2909175 Disease Relevance 1.67 Pain Relevance 0.44
In 2 patients who had chest pain and increased troponin T, MCE excluded ACS by identifying perimyocarditis as the underlying cause.
Positive_regulation (increased) of troponin T in chest associated with acute coronary syndrome and angina
15) Confidence 0.67 Published 2004 Journal Am. J. Cardiol. Section Abstract Doc Link 15541235 Disease Relevance 1.10 Pain Relevance 0.37
Elevation of troponin T was detected in 3 patients (4.4%), which was also closely related to elevated drug concentrations and interpreted as myocardial damage associated with the therapy.
Positive_regulation (Elevation) of troponin T
16) Confidence 0.67 Published 2003 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 12975596 Disease Relevance 0.73 Pain Relevance 0.21
Two thirds of the patients with unstable angina had no increase in serum troponin T (<0.1 microg/L) (n = 80).
Neg (no) Positive_regulation (increase) of troponin T associated with angina
17) Confidence 0.67 Published 2000 Journal Am. J. Cardiol. Section Abstract Doc Link 10758918 Disease Relevance 1.24 Pain Relevance 0.54
Patients with elevated troponin-T had a significantly greater risk of cardiac events over the next 6 months than patients with normal troponin-T.
Positive_regulation (elevated) of troponin-T
18) Confidence 0.67 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9285668 Disease Relevance 0.35 Pain Relevance 0.25
The time of total elevation of CKMB mass levels above the discrimination limit does not differ from the time taken to raise CK values, it is however shorter than the increase of troponin T values, although the exact time of persistence of raised levels of troponin T was not assessed in our work.
Positive_regulation (increase) of troponin T
19) Confidence 0.67 Published 1997 Journal Vnitr Lek Section Abstract Doc Link 9650501 Disease Relevance 0.20 Pain Relevance 0.09
Additional data from GUSTO IIa showed that elevated troponin-T levels were associated with a higher incidence of mortality.
Positive_regulation (elevated) of troponin-T
20) Confidence 0.67 Published 1998 Journal Eur. Heart J. Section Abstract Doc Link 9790282 Disease Relevance 0.55 Pain Relevance 0.28

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