INT5743

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Context Info
Confidence 0.59
First Reported 1980
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 104
Total Number 105
Disease Relevance 14.35
Pain Relevance 35.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
urine 3
plasma 2
striatum 2
brain 2
hippocampus 2
NA (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 121 100.00 Very High Very High Very High
noradrenaline 109 100.00 Very High Very High Very High
Dopamine 62 100.00 Very High Very High Very High
Nicotine 28 100.00 Very High Very High Very High
Glutamate 23 100.00 Very High Very High Very High
nMDA receptor 11 100.00 Very High Very High Very High
Somatostatin 11 100.00 Very High Very High Very High
gABA 28 99.84 Very High Very High Very High
Gabapentin 70 99.68 Very High Very High Very High
Hippocampus 30 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 33 100.00 Very High Very High Very High
Vomiting 4 100.00 Very High Very High Very High
Liver Disease 1 99.84 Very High Very High Very High
Congenital Anomalies 27 99.58 Very High Very High Very High
Diuresis 48 99.38 Very High Very High Very High
Increased Venous Pressure Under Development 19 99.20 Very High Very High Very High
Stress 163 99.04 Very High Very High Very High
Gallstones 4 99.00 Very High Very High Very High
Cv Unclassified Under Development 41 98.84 Very High Very High Very High
Stress Incontinence 8 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A review of the literature and these cases indicate that associated risk factors for hyponatremia after DDAVP administration include stress, surgery, anesthesia and narcotics (endogenous release of antidiuretic hormone), vomiting (loss of Na+), liver disease (hindered metabolism of DDAVP), renal tubular acidosis (chronically low serum Na+), multiple doses of DDAVP, and overhydration with hyponatremic fluids.
Localization (release) of Na in liver associated with liver disease, stress, hyponatremia, anesthesia, vomiting and renal tubular acidosis
1) Confidence 0.59 Published 1989 Journal Am. J. Hematol. Section Abstract Doc Link 2500851 Disease Relevance 1.21 Pain Relevance 0.10
In model A, addition of 5.0 g/L TX to ORS reversed Na+ secretion and improved net water as well as K+ and glucose absorption, compared with THEO-treated rats perfused with ORS without TX.
Localization (secretion) of Na
2) Confidence 0.58 Published 1999 Journal Pediatr. Res. Section Abstract Doc Link 10088661 Disease Relevance 0.52 Pain Relevance 0.07
Long-term antidepressant administration reduces the inhibitory influence of clonidine and HT on presynaptic release of 14C-NA and 3H-HT by brain slices.
Localization (release) of NA in brain associated with antidepressant and clonidine
3) Confidence 0.58 Published 1986 Journal Biull Eksp Biol Med Section Abstract Doc Link 3708140 Disease Relevance 0 Pain Relevance 0.44
We examined the ability of morphine and U-50,488 H administered acutely to the rat to modify the hypothalamic noradrenaline (NA) content and turnover as well as corticosterone release.
Localization (release) of NA associated with noradrenaline and morphine
4) Confidence 0.58 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657482 Disease Relevance 0 Pain Relevance 0.59
Increases in urinary excretion of K+ and Na+ by K+ loading accompanied an increase in renal KK secretion.
Localization (excretion) of Na
5) Confidence 0.55 Published 1999 Journal Immunopharmacology Section Abstract Doc Link 10604541 Disease Relevance 0.09 Pain Relevance 0.08
Twelve-hour collected urine was measured for urinary excretion of K+ and Na+ and urinary activity of renal KK.
Localization (excretion) of Na in urine
6) Confidence 0.55 Published 1999 Journal Immunopharmacology Section Abstract Doc Link 10604541 Disease Relevance 0.10 Pain Relevance 0.08
Class I antiarrhythmics inhibit Na+ absorption and Cl- secretion in rabbit descending colon epithelium.
Localization (secretion) of Na in descending colon
7) Confidence 0.51 Published 2005 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 16012869 Disease Relevance 0.10 Pain Relevance 0.28
To clarify the mechanism of the diarrhea associated with the clinical use of antiarrhythmic drugs we assessed the effects of these agents on transepithelial Na+ absorption and Cl- secretion, on basolateral K+ conductance, and on the properties of single basolateral K+ channels of rabbit colon epithelium.
Localization (secretion) of Na in epithelium associated with diarrhoea
8) Confidence 0.51 Published 2005 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 16012869 Disease Relevance 0.10 Pain Relevance 0.16
(iii) With additional time in culture, a majority of cells exhibit a Ca2+ current at the time of Na+ channel appearance in or near the cell body as well as a transient Ca2+-dependent outward current.
Localization (appearance) of Na in cell body
9) Confidence 0.46 Published 1986 Journal Brain Res. Section Abstract Doc Link 2427171 Disease Relevance 0 Pain Relevance 0.28
By contrast, the species-specific suppressor from M. pinodes inhibited the elicitor-induced release of Na+ and K+ ions from pea tissues, but, conversely, by itself it elicited either the defense response or the release of Na+ and K+ ions from cowpea tissues.
Localization (release) of Na
10) Confidence 0.44 Published 1997 Journal Plant Cell Physiol. Section Abstract Doc Link 9249987 Disease Relevance 0 Pain Relevance 0.06
By contrast, the species-specific suppressor from M. pinodes inhibited the elicitor-induced release of Na+ and K+ ions from pea tissues, but, conversely, by itself it elicited either the defense response or the release of Na+ and K+ ions from cowpea tissues.
Localization (release) of Na
11) Confidence 0.44 Published 1997 Journal Plant Cell Physiol. Section Abstract Doc Link 9249987 Disease Relevance 0 Pain Relevance 0.07
It is concluded that: (1) at rest there is a net secretion of Na+, K+, Cl-, and water by the human proximal duodenum; and (2) PGE2-stimulated water electrolyte secretion is dependent in part upon mucosal carbonic anhydrase activity and the enteric nervous system.
Localization (secretion) of Na in proximal
12) Confidence 0.40 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7851184 Disease Relevance 0 Pain Relevance 0.17
At rest, mean basal (95% confidence intervals) net ion secretion into the human proximal duodenum was: Cl- 670 (288-1052), Na+ 818 (410-1225), K+ 32 (14-51) mumol/cm/hr.
Localization (secretion) of Na in duodenum
13) Confidence 0.40 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7851184 Disease Relevance 0 Pain Relevance 0.17
It is concluded that: (1) at rest there is a net secretion of Na+, K+, Cl-, and water by the human proximal duodenum; and (2) PGE2-stimulated water electrolyte secretion is dependent in part upon mucosal carbonic anhydrase activity and the enteric nervous system.
Localization (secretion) of Na in proximal
14) Confidence 0.40 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7851184 Disease Relevance 0 Pain Relevance 0.17
Although removal of extracellular Na+ blocked secretion produced by nicotine, tetrodotoxin, which abolished voltage-activated Na+ currents, had no effect on nicotine-induced secretion, even at low nicotine concentrations.
Localization (secretion) of Na associated with tetrodotoxin and nicotine
15) Confidence 0.39 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8667180 Disease Relevance 0 Pain Relevance 0.63
The most obvious effect of the mutation is an increase in late Na+ channel current over a broad range of cellular membrane potentials, an effect similar to other previously-described LQT-3 mutations such as the ?
Localization (current) of Na
16) Confidence 0.39 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2082660 Disease Relevance 0 Pain Relevance 0.17
The ability to induce biliary secretion of Na+ and Cl- also decreased when Cl- was replaced by NO3- or isethionate and when Na+ was replaced by Li+, respectively.
Localization (secretion) of Na
17) Confidence 0.27 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6842392 Disease Relevance 0.13 Pain Relevance 0.03
Biliary secretion of Na+ or Cl- declined during cholestasis and increased during choleresis.
Localization (secretion) of Na associated with gallstones
18) Confidence 0.27 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6842392 Disease Relevance 0.17 Pain Relevance 0.14
In this context, the presence of epithelial Na+ channels of the ENaC family has been demonstrated in sperm cells [19].
Localization (presence) of Na in sperm cells
19) Confidence 0.25 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 0
Although phenytoin (10 microM), carbamazepine (100 microM) and lamotrigine (10 microM) also decreased [3H]-NA release (by 25%, 57% and 22%, respectively), glibenclamide did not antagonize the effects of these classical Na+ channel blockers.
Localization (release) of NA associated with lamotrigine and carbamazepine
20) Confidence 0.22 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11383714 Disease Relevance 0 Pain Relevance 1.00

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