INT57431

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Context Info
Confidence 0.30
First Reported 1994
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 4.35
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PIAS1) nucleus (PIAS1) enzyme binding (PIAS1)
DNA binding (PIAS1) ligase activity (PIAS1)
Anatomy Link Frequency
liver 2
neuronal 1
mesentery 1
papilla 1
PIAS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Gabapentin 12 100.00 Very High Very High Very High
Lamotrigine 12 94.96 High High
abdominal pain 12 94.80 High High
Bile 21 87.64 High High
imagery 3 82.36 Quite High
antiepileptic Drug 12 75.00 Quite High
carbamazepine 4 62.48 Quite High
Calcium channel 2 50.00 Quite Low
Inflammation 6 48.80 Quite Low
gABA 4 48.00 Quite Low
Disease Link Frequency Relevance Heat
Carcinoma 24 99.36 Very High Very High Very High
Disease 6 96.04 Very High Very High Very High
Vomiting 3 95.28 Very High Very High Very High
Gallstones 21 95.20 Very High Very High Very High
Abdominal Pain 12 94.80 High High
Weight Loss 8 94.16 High High
Partial Seizures 2 93.28 High High
Cancer 18 93.12 High High
Syndrome 4 92.44 High High
Obstructive Jaundice 3 90.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GBP, which was recently found to bind to the alpha2delta subunit of a neuronal Ca2+ channel, showed no modulation of Ca2+ conductances.
GBP Binding (bind) of in neuronal
1) Confidence 0.30 Published 1998 Journal Epilepsia Section Body Doc Link 9578025 Disease Relevance 0.06 Pain Relevance 0
Associated GBP, as in our patient, is extremely uncommon.
GBP Binding (Associated) of
2) Confidence 0.29 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2887867 Disease Relevance 1.01 Pain Relevance 0.18
Gallbladder wall thickening, pericholecystic fluid collection, and a streaky omentum or mesentery are common findings of GBP [1,7-9].
GBP Binding (findings) of in mesentery
3) Confidence 0.26 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2887867 Disease Relevance 0.78 Pain Relevance 0.06
Although extremely rare, carcinoma of the duodenal papilla can be associated with GBP and display acute manifestations.
GBP Binding (associated) of in papilla associated with carcinoma
4) Confidence 0.25 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2887867 Disease Relevance 1.09 Pain Relevance 0.12
GBP is not metabolized by the liver and has no drug interactions.
GBP Neg (no) Binding (interactions) of in liver associated with gabapentin
5) Confidence 0.19 Published 1994 Journal Epilepsia Section Abstract Doc Link 8174517 Disease Relevance 0.70 Pain Relevance 0.79
GBP is not metabolized by the liver and has no drug interactions.
GBP Neg (no) Binding (interactions) of in liver associated with gabapentin
6) Confidence 0.15 Published 1994 Journal Epilepsia Section Abstract Doc Link 8174517 Disease Relevance 0.70 Pain Relevance 0.79

General Comments

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