INT57433

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Context Info
Confidence 0.49
First Reported 1993
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.62
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EDN1) extracellular region (EDN1) cell-cell signaling (EDN1)
cytoplasm (EDN1)
Anatomy Link Frequency
endothelium 4
amniotic fluid 2
EDN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 99.56 Very High Very High Very High
antagonist 9 99.52 Very High Very High Very High
cytokine 1 97.36 Very High Very High Very High
lidocaine 1 96.72 Very High Very High Very High
anesthesia 2 89.72 High High
Dismenorea 1 83.20 Quite High
agonist 1 60.92 Quite High
Inflammatory response 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 4 100.00 Very High Very High Very High
INFLAMMATION 3 99.92 Very High Very High Very High
Dysmenorrhea 1 83.20 Quite High
Wheal 1 75.16 Quite High
Disease 1 44.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We demonstrate that in brachial arteries of steroid exposed offspring: KCl induced contraction is increased after endothelium removal or incubation with inhibitors of nitric oxide synthase or cyclooxygenase; acetylcholine-induced relaxation is increased; sensitivity to endothelin-1 (ET-1) is increased and this effect is decreased by the ETB antagonist BQ-788.
Positive_regulation (increased) of endothelin-1 Binding (sensitivity) of in endothelium associated with antagonist
1) Confidence 0.49 Published 2006 Journal Pediatr. Res. Section Abstract Doc Link 17065564 Disease Relevance 0 Pain Relevance 0.14
We demonstrate that in brachial arteries of steroid exposed offspring: KCl induced contraction is increased after endothelium removal or incubation with inhibitors of nitric oxide synthase or cyclooxygenase; acetylcholine-induced relaxation is increased; sensitivity to endothelin-1 (ET-1) is increased and this effect is decreased by the ETB antagonist BQ-788.
Positive_regulation (increased) of ET-1 Binding (sensitivity) of in endothelium associated with antagonist
2) Confidence 0.49 Published 2006 Journal Pediatr. Res. Section Abstract Doc Link 17065564 Disease Relevance 0 Pain Relevance 0.14
Endothelin-1- and endothelin-3-induced vasodilation in the surrounding area were also inhibited by both endothelin antagonists or by lidocaine.
Positive_regulation (endothelin-3-induced) of Endothelin-1 Binding (vasodilation) of associated with antagonist, increased venous pressure under development and lidocaine
3) Confidence 0.44 Published 1994 Journal Hypertension Section Abstract Doc Link 8175165 Disease Relevance 0.43 Pain Relevance 0.36
Increased ET-1 formation in these tissues of the forebag would be indicative that the greater rate of ET-1 formation and entry into amniotic fluid was an aftereffect of labor, not a cause of parturition.
Positive_regulation (Increased) of ET-1 Binding (formation) of in amniotic fluid
4) Confidence 0.39 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8501173 Disease Relevance 0.18 Pain Relevance 0.18

General Comments

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