INT57441

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Context Info
Confidence 0.40
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 2.72
Pain Relevance 4.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) endoplasmic reticulum (Prkca) enzyme binding (Prkca)
protein complex (Prkca) cytoplasm (Prkca) cytosol (Prkca)
Anatomy Link Frequency
neurons 4
neuronal 2
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 278 100.00 Very High Very High Very High
qutenza 82 100.00 Very High Very High Very High
Morphine 155 99.70 Very High Very High Very High
Neurotransmitter 40 95.76 Very High Very High Very High
agonist 25 95.00 High High
opioid receptor 168 94.12 High High
long-term potentiation 20 93.48 High High
Neuritis 1 92.16 High High
imagery 1 89.68 High High
tolerance 56 84.08 Quite High
Disease Link Frequency Relevance Heat
Nociception 78 99.26 Very High Very High Very High
Virus Diseases 188 98.72 Very High Very High Very High
Disease 33 96.16 Very High Very High Very High
Infection 41 94.00 High High
Neuritis 1 92.16 High High
Congenital Anomalies 27 89.44 High High
Targeted Disruption 56 87.88 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 5 86.80 High High
INFLAMMATION 42 70.72 Quite High
Pain 57 62.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phosphorylation of MARCKS by PKC is implicated in actin-dependent cytoskeletal plasticity [41] and has been associated with PKC-mediated enhancement of neurotransmitter release, as well as with persistence of LTP in vivo [42].
Positive_regulation (implicated) of Phosphorylation (phosphorylation) of PKC associated with neurotransmitter, kinase c and long-term potentiation
1) Confidence 0.40 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.79 Pain Relevance 0.73
BDV replication is tightly regulated by complex mechanisms and the phosphorylation of P by PKC could increase the activity of the viral polymerase complex, thereby contributing to BDV adaptation to persistence in neurons [45,46].
Positive_regulation (increase) of Phosphorylation (phosphorylation) of PKC in neurons associated with virus diseases and kinase c
2) Confidence 0.40 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.71 Pain Relevance 0.45
These data suggest that serine 209 at the C-terminus of protein F1 may be a substrate for PKC phosphorylation in vivo.
Positive_regulation (substrate) of Phosphorylation (phosphorylation) of PKC
3) Confidence 0.26 Published 1994 Journal Neurochem. Res. Section Abstract Doc Link 8177366 Disease Relevance 0.09 Pain Relevance 0.16
PDK1 is recruited to the membrane by PI3K-generated PIP3 (5) where it phosphorylates and activates AGC kinases, such as PKC and Akt, through phosphorylation of Akt Thr308 (6).
Positive_regulation (phosphorylates) of Phosphorylation (phosphorylates) of PKC associated with kinase c
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 0.62
The 10 nmol morphine dose promoted PKC-mediated phosphorylation of NMDAR1 Ser890 and Src-mediated phosphorylation of NMDAR2A Tyr1325.
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of PKC associated with kinase c and morphine
5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.22
The phosphorylation of Serine845 in GluR1 by PKA regulates the open-channel probability of AMPA receptors; whereas the phosphorylation of Serine831 by PKC changes channel conductance [39].
Positive_regulation (changes) of Phosphorylation (phosphorylation) of PKC associated with kinase c
6) Confidence 0.18 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.13 Pain Relevance 0.20
The Transient Receptor Potential cation channel V1 (TRPV1) is expressed in peripheral nociceptive neurons and is subject to polymodal activation via various agents including capsaicin, noxious heat, low extracellular pH, and direct phosphorylation by protein kinase C (PKC).
Positive_regulation (activation) of Phosphorylation (phosphorylation) of PKC in neurons associated with nociception, kinase c and qutenza
7) Confidence 0.12 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15489017 Disease Relevance 0.10 Pain Relevance 0.54
PKC-mediated phosphorylation of TRPV1 in DRG neuronal cultures has been shown to produce faster activation and slower deactivation of the channel [4].
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of PKC in neuronal
8) Confidence 0.12 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 0.17 Pain Relevance 0.31
Most of these channels are modulated by PKA and PKC mediated phosphorylation.
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of PKC associated with kinase c
9) Confidence 0.10 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563450 Disease Relevance 0.46 Pain Relevance 0.47
The rod-like region of the dystrophin and utrophin proteins contain potential protein kinase G (PKG) phosphorylation sites, while potential protein kinase C (PKC) phosphorylation sites are located near the actin-binding sites [78].
Positive_regulation (potential) of Phosphorylation (phosphorylation) of PKC associated with kinase c
10) Confidence 0.07 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.16 Pain Relevance 0.18
In addition, the phosphorylation of CUGBP1 on the putative PKC sites might stabilize CUGBP1 in DM1 cells leading to the enhancement of CUGBP1 functions.
Spec (might) Positive_regulation (stabilize) of Phosphorylation (phosphorylation) of PKC
11) Confidence 0.06 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.10 Pain Relevance 0

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