INT57501

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Context Info
Confidence 0.27
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 3.67
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (CREM) signal transduction (CREM) nucleus (CREM)
DNA binding (CREM)
Anatomy Link Frequency
kidney 1
CREM (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 6 98.88 Very High Very High Very High
rheumatoid arthritis 8 97.84 Very High Very High Very High
Osteoarthritis 86 95.88 Very High Very High Very High
Infliximab 36 93.52 High High
Etanercept 35 93.16 High High
Adalimumab 36 92.92 High High
cva 36 90.16 High High
Morphine 7 88.20 High High
Post herpetic neuralgia 110 76.20 Quite High
nud 52 74.64 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 38 97.84 Very High Very High Very High
Osteoarthritis 86 95.88 Very High Very High Very High
Ulcers 92 90.24 High High
Cv General 3 Under Development 36 90.16 High High
Peripheral Arterial Disease 54 90.08 High High
Deafness 5 89.36 High High
Stroke 16 88.20 High High
Aging 9 87.52 High High
Asthma 2 84.20 Quite High
Disease Progression 7 78.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results support a model in which the protein(s) binding to the cAMP-responsive element integrates signals initiated by multiple pathways (cAMP and calcium) and transmits that integrated signal to the basal transcription machinery, resulting in increased levels of gene expression.
cAMP-responsive element Binding (binding) of
1) Confidence 0.27 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 8182084 Disease Relevance 0 Pain Relevance 0.04
Furthermore, ICER competes for p-CREB binding to the cAMP-responsive elements (CREs) site.
ICER Binding (competes) of
2) Confidence 0.20 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17227776 Disease Relevance 0 Pain Relevance 0.54
This was also the case in the study by Marra et al. [39], who used mapping to estimate the ICER associated with two different drug strategies for patients with rheumatoid arthritis.
ICER Binding (associated) of associated with rheumatoid arthritis
3) Confidence 0.20 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2490675 Disease Relevance 0.41 Pain Relevance 0.05
The ICER declines to $19,309 when account is taken of the increase in PUB risks with advancing age.
ICER Binding (declines) of
4) Confidence 0.16 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1925103 Disease Relevance 0.65 Pain Relevance 0.33
The ICER declined to $19,309 when age-related increases in PUB risks were factored into the base-model assumptions (Table 5).
ICER Binding (declined) of
5) Confidence 0.16 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1925103 Disease Relevance 0.45 Pain Relevance 0.15
By summing the incremental costs and QALYs of the vaccinated populations of interest, the overall ICER associated with any age-specific vaccination strategy can be observed.
ICER Binding (associated) of
6) Confidence 0.07 Published 2010 Journal Cost Eff Resour Alloc Section Body Doc Link PMC2881001 Disease Relevance 0.65 Pain Relevance 0.40
This transcription factor binds as a homodimer to the cAMP-responsive element and induces transcription of genes in response to hormonal stimulation [25].
cAMP-responsive element Binding (homodimer) of
7) Confidence 0.04 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2529314 Disease Relevance 0.71 Pain Relevance 0
Transfections were performed with CRE-Luciferase a specific cis-acting DNA binding sequence of the cAMP response element ligated with a Luciferase reporter plasmid (Clontech Laboratories, BD Bioscience, Cowley, UK) or the COX-2 promoter, performed using C2.1 (?
cAMP response element Binding (binding) of
8) Confidence 0.03 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0 Pain Relevance 0.03
The base-case ICER was found to be around 30 000 pounds (?
ICER Binding (pounds) of
9) Confidence 0.03 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2838414 Disease Relevance 0.49 Pain Relevance 0.62
A monkey kidney cDNA that encodes a nuclear regulatory factor was identified by expression and affinity binding to a synthetic retinoic acid response element (RARE) and was used to isolate human placental and rat germ cell cDNAs by hybridization.
acid response element Binding (binding) of in kidney
10) Confidence 0.01 Published 1998 Journal Mol. Endocrinol. Section Abstract Doc Link 9773984 Disease Relevance 0.30 Pain Relevance 0
Most RXR/partner heterodimers recognize and bind to direct repeat (DR) DNA sequences as their response element [18–23].
response element Binding (bind) of
11) Confidence 0.00 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0

General Comments

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