INT57502

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Context Info
Confidence 0.70
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 23.37
Pain Relevance 5.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CRH) extracellular space (CRH) extracellular region (CRH)
response to stress (CRH)
Anatomy Link Frequency
plasma 6
hypothalamus 6
PC-12 2
brain structures 2
joint 2
CRH (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 65 99.60 Very High Very High Very High
corticosteroid 25 98.78 Very High Very High Very High
Fibrositis 81 98.60 Very High Very High Very High
withdrawal 28 98.44 Very High Very High Very High
depression 198 98.12 Very High Very High Very High
cytokine 197 97.60 Very High Very High Very High
Inflammation 312 97.32 Very High Very High Very High
Neuropeptide 40 96.88 Very High Very High Very High
amygdala 32 96.76 Very High Very High Very High
Limbic system 20 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 569 100.00 Very High Very High Very High
Pulmonary Disease 132 100.00 Very High Very High Very High
Heart Failure 124 100.00 Very High Very High Very High
Chronic Renal Failure 110 100.00 Very High Very High Very High
Volume Depletion And Dehydration 4 99.98 Very High Very High Very High
Infection 315 99.74 Very High Very High Very High
Premature Birth 893 99.60 Very High Very High Very High
Osteoarthritis 20 99.00 Very High Very High Very High
Necrosis 25 98.92 Very High Very High Very High
Sleep Disorders 93 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Earlier preterm births are thought more likely to be due to infective or inflammatory etiologies [25] while late preterm births have been suggested to be due to disturbances in the gestational length mechanisms such as increased CRH production from the placenta.
Positive_regulation (increased) of Gene_expression (production) of CRH in placenta associated with inflammation and premature birth
1) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890413 Disease Relevance 0.78 Pain Relevance 0.10
This is supported by studies in mice that genetically overexpress CRH.
Positive_regulation (overexpress) of Gene_expression (overexpress) of CRH
2) Confidence 0.60 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC544567 Disease Relevance 0.41 Pain Relevance 0.33
The corticotrophin producing cells of the anterior pituitary synergise CRH and the AVP through CRH-RI and VIb receptors respectively to increase expression of the adreno-corticotropin hormone (ACTH) precursor, and further promote the release of ACTH into the systemic circulation [53].
Positive_regulation (increase) of Gene_expression (expression) of adreno-corticotropin hormone in anterior pituitary
3) Confidence 0.59 Published 2006 Journal Chiropr Osteopat Section Body Doc Link PMC1629015 Disease Relevance 0.07 Pain Relevance 0.12
In only one of these (Banki et al., 1987) was there any evidence of increased basal levels of CRH, although this was largely due to extremely high levels in three individuals.
Positive_regulation (increased) of Gene_expression (levels) of CRH
4) Confidence 0.51 Published 2010 Journal Journal of Psychopharmacology (Oxford, England) Section Body Doc Link PMC2951595 Disease Relevance 0.23 Pain Relevance 0.03
In order to test if antidepressant drugs can directly influence corticotropin-releasing hormone (CRH) gene expression, their effect on CRH gene promoter activity was evaluated in neuro-2A cells stably transfected with a human CRH - chloramphenicol acetyl-transferase plasmid.
Positive_regulation (influence) of Gene_expression (expression) of corticotropin-releasing hormone associated with antidepressant
5) Confidence 0.50 Published 2002 Journal Pol J Pharmacol Section Abstract Doc Link 12866730 Disease Relevance 0 Pain Relevance 0.19
In order to test if antidepressant drugs can directly influence corticotropin-releasing hormone (CRH) gene expression, their effect on CRH gene promoter activity was evaluated in neuro-2A cells stably transfected with a human CRH - chloramphenicol acetyl-transferase plasmid.
Positive_regulation (influence) of Gene_expression (expression) of CRH associated with antidepressant
6) Confidence 0.50 Published 2002 Journal Pol J Pharmacol Section Abstract Doc Link 12866730 Disease Relevance 0 Pain Relevance 0.19
Multiple research groups have demonstrated during the last decade the expression of the CRF peptides and their receptors in several components of the immune system and their participation in the ad hoc regulation of inflammatory phenomena.
Positive_regulation (demonstrated) of Gene_expression (expression) of CRF in immune system associated with inflammation
7) Confidence 0.49 Published 2005 Journal Curr. Med. Chem. Section Abstract Doc Link 15974983 Disease Relevance 1.21 Pain Relevance 0.42
CRH is produced by fetomaternal tissues and secreted into the maternal circulation, so that during pregnancy the maternal plasma levels of this hormone increase while of the corresponding binding protein (CRH-BP) is reduced [14,15].
Positive_regulation (increase) of Gene_expression (produced) of CRH in plasma
8) Confidence 0.48 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1513580 Disease Relevance 0.42 Pain Relevance 0.12
In PC-12 cells, potassium-induced membrane depolarization increased expression of a CRH-reporter construct in a cAMP-dependent manner.
Positive_regulation (increased) of Gene_expression (expression) of CRH-reporter in PC-12
9) Confidence 0.46 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 8182084 Disease Relevance 0 Pain Relevance 0.04
The HPA-axis theory postulates that corticosteroid-receptor signaling is disrupted by some external mechanism, increasing CRH synthesis and release in brain structures implicated in depression and culminating in its pathogenesis (Holsboer, 2000).
Positive_regulation (increasing) of Gene_expression (synthesis) of CRH in brain structures associated with corticosteroid and depression
10) Confidence 0.46 Published 2010 Journal Frontiers in Neuroengineering Section Body Doc Link PMC2901135 Disease Relevance 0.77 Pain Relevance 0.53
Gold and Chrousos [15] have hypothesized that new onset FM is generally associated with a hyperactive HPA axis characterized by elevated levels of CRH and cortisol (a characteristic of MDE), and that, over time, persistent stress results in blunting of the HPA axis response (a characteristic of ADE).
Positive_regulation (elevated) of Gene_expression (levels) of CRH associated with stress and fibrositis
11) Confidence 0.45 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2909161 Disease Relevance 1.40 Pain Relevance 0.44
Patients at risk for preterm birth have significantly elevated plasma levels of CRH and lower CRH-BP levels [17].
Positive_regulation (elevated) of Gene_expression (levels) of CRH in plasma associated with premature birth
12) Confidence 0.45 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1513580 Disease Relevance 0.26 Pain Relevance 0.10
The first wave of hormonal mediators of the stress response stimulates the production of hypothalamic CRH, which inhibits gonado-tropin releasing hormone (GnRH).
Positive_regulation (stimulates) of Gene_expression (production) of CRH associated with stress
13) Confidence 0.40 Published 2006 Journal Chiropr Osteopat Section Body Doc Link PMC1629015 Disease Relevance 0.57 Pain Relevance 0.05
Patients at risk for PTB have significantly elevated plasma levels of CRH and lower CRH-BP levels (Hobel et al., 1999).
Positive_regulation (elevated) of Gene_expression (levels) of CRH in plasma associated with premature birth
14) Confidence 0.37 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0.17 Pain Relevance 0.24
Maternal stress, in the absence of other mediators of preterm birth such as infection, results in increased levels of biological effectors of stress including cortisol and epinephrine, which could activate placental CRH gene expression.
Positive_regulation (activate) of Gene_expression (expression) of CRH gene associated with stress, premature birth and infection
15) Confidence 0.34 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC2841774 Disease Relevance 1.34 Pain Relevance 0.03
Parturition involves a progressive cascade of events initiated by HPA activation and increased placental CRH expression, leading to a functional progesterone withdrawal and estrogen activation, which results in the expression and activation of contraction-associated proteins (CAPs), including oxytocin, and prostaglandin receptors.
Positive_regulation (increased) of Gene_expression (expression) of CRH associated with withdrawal
16) Confidence 0.34 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC2841774 Disease Relevance 0.31 Pain Relevance 0.13
Intravenous as well as intraperitoneal applications of IL-1 result in an increased CRH production in the hypothalamus [176, 177].
Positive_regulation (increased) of Gene_expression (production) of CRH in hypothalamus
17) Confidence 0.33 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 1.25 Pain Relevance 0.51
, stimulate the production of corticotropin-releasing hormone (CRH) and of adrenocotricotrophic hormone (ACTH; corticotropin; Fig. 1).
Positive_regulation (stimulate) of Gene_expression (production) of corticotropin-releasing hormone
18) Confidence 0.32 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.85 Pain Relevance 0.21
, stimulate the production of corticotropin-releasing hormone (CRH) and of adrenocotricotrophic hormone (ACTH; corticotropin; Fig. 1).
Positive_regulation (stimulate) of Gene_expression (production) of CRH
19) Confidence 0.32 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.85 Pain Relevance 0.21
These data suggest the relationship between maternal psychological stress and prematurity may be mediated by prematurely increased expression of placental CRH.
Positive_regulation (increased) of Gene_expression (expression) of CRH associated with stress
20) Confidence 0.30 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC2841774 Disease Relevance 0.68 Pain Relevance 0.03

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