INT57508

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Context Info
Confidence 0.01
First Reported 1994
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.22
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Adarb1) intracellular (Adarb1) cell-cell signaling (Pomc)
cytoplasm (Pomc) extracellular space (Pomc) generation of precursor metabolites and energy (Pomc)
Pomc (Rattus norvegicus)
Adarb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 5 100.00 Very High Very High Very High
antinociception 5 96.80 Very High Very High Very High
Antinociceptive 2 92.84 High High
Opioid 2 90.72 High High
antagonist 2 90.16 High High
Pain 1 82.88 Quite High
Analgesic 3 79.76 Quite High
Central grey 3 76.48 Quite High
Disease Link Frequency Relevance Heat
Pain 1 82.88 Quite High
Urological Neuroanatomy 3 76.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This drug effect was partly antagonized in dose-related fashion by i.c.v. pretreatment with naltrexone, D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 and beta-endorphin, which block multiple, mu and epsilon opioid receptors, respectively.
beta-endorphin Negative_regulation (block) of receptors associated with opioid receptor
1) Confidence 0.01 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8182525 Disease Relevance 0.22 Pain Relevance 1.05

General Comments

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