INT57524

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Context Info
Confidence 0.43
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 2.09
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sars) ligase activity (Sars) cytoplasm (Sars)
Anatomy Link Frequency
ganglia 2
mechanosensory neurons 1
smooth muscle 1
nerve 1
Sars (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 42 99.52 Very High Very High Very High
qutenza 34 94.76 High High
lidocaine 5 91.60 High High
vagus nerve 19 87.12 High High
addiction 7 80.20 Quite High
substance P 47 69.20 Quite High
Inflammation 10 67.76 Quite High
Analgesic 2 67.60 Quite High
medulla 28 67.20 Quite High
bradykinin 14 66.56 Quite High
Disease Link Frequency Relevance Heat
Severe Acute Respiratory Syndrome 1 100.00 Very High Very High Very High
INFLAMMATION 15 98.44 Very High Very High Very High
Cough 229 93.36 High High
Apnoea 9 86.04 High High
Dyspnea 6 85.00 Quite High
Toxicity 1 65.36 Quite High
Bronchospasm 7 61.68 Quite High
Targeted Disruption 4 56.00 Quite High
Hyperalgesia 1 52.16 Quite High
Ganglion Cysts 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether this rhythmic ATP release requires vagal nerve input, the nerve was exposed to allow reversible blockade of the conductance (including pulmonary SARs conductance) by topical application of local anaesthetic.
Gene_expression (conductance) of SARs in nerve
1) Confidence 0.43 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538935 Disease Relevance 0.37 Pain Relevance 0.20
Synthesis and SARS of some 2-heteroaryl derivatives with antiinflammatory and related activities.
Gene_expression (Synthesis) of SARS associated with inflammation and severe acute respiratory syndrome
2) Confidence 0.36 Published 1994 Journal Farmaco Section Title Doc Link 8185747 Disease Relevance 0.42 Pain Relevance 0.12
-fibres in ASIC3 null mutants in that the mechanical threshold of RARs, but not that of SARs, was lowered [27].
Gene_expression (threshold) of SARs
3) Confidence 0.09 Published 2006 Journal Respir Res Section Body Doc Link PMC1524950 Disease Relevance 0.18 Pain Relevance 0.15
Furthermore, pulmonary smooth muscle associated receptors (likely SARs) and laryngeal mechanosensors express calretinin in rats [21,40,41], and parvalbumin and calbindin have been shown to be reliable markers for a variety of other vagal (or other visceral) mechanosensory neurons [42-44].
Gene_expression (express) of SARs in mechanosensory neurons
4) Confidence 0.05 Published 2008 Journal Cough Section Body Doc Link PMC2586627 Disease Relevance 0.28 Pain Relevance 0.06
Few capsaicin-sensitive airway afferents arising from the nodose ganglia innervate the guinea pig trachea (most originate from the jugular ganglia) and in guinea pigs the mechanically-sensitive nodose nerve endings in the trachea don't display the characteristics of RARs or SARs (although other species such as dogs and rabbits possess RARs and/or SARs in the trachea) [1,2,19,20].
Gene_expression (possess) of SARs in ganglia associated with qutenza
5) Confidence 0.05 Published 2008 Journal Cough Section Body Doc Link PMC2586627 Disease Relevance 0.37 Pain Relevance 0.37
Few capsaicin-sensitive airway afferents arising from the nodose ganglia innervate the guinea pig trachea (most originate from the jugular ganglia) and in guinea pigs the mechanically-sensitive nodose nerve endings in the trachea don't display the characteristics of RARs or SARs (although other species such as dogs and rabbits possess RARs and/or SARs in the trachea) [1,2,19,20].
Gene_expression (possess) of SARs in ganglia associated with qutenza
6) Confidence 0.05 Published 2008 Journal Cough Section Body Doc Link PMC2586627 Disease Relevance 0.36 Pain Relevance 0.42
In virtually all mammals studied thus far inhalation of a smooth muscle spasmogen, such as histamine, leads to action potential discharge in RARs, and less commonly in SARs.
Gene_expression (less) of SARs in smooth muscle associated with action potential
7) Confidence 0.05 Published 2001 Journal Respir Res Section Body Doc Link PMC59581 Disease Relevance 0.11 Pain Relevance 0.09

General Comments

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