INT57525

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.20
Pain Relevance 4.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ltf) transport (Ltf) extracellular region (Ltf)
cytoplasm (Ltf)
Anatomy Link Frequency
neuronal 2
plasma 2
brainstem 1
lung 1
Ltf (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 18 98.32 Very High Very High Very High
tolerance 12 97.84 Very High Very High Very High
medulla 2 97.16 Very High Very High Very High
Inflammation 156 90.28 High High
cytokine 41 84.96 Quite High
Inflammatory stimuli 2 84.20 Quite High
analgesia 8 83.00 Quite High
tail-flick 2 73.20 Quite High
fibrosis 95 71.20 Quite High
Endogenous opioid 2 71.04 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 4 98.24 Very High Very High Very High
Reperfusion Injury 2 97.12 Very High Very High Very High
Targeted Disruption 44 96.24 Very High Very High Very High
Cough 5 95.76 Very High Very High Very High
Stress 7 94.52 High High
INFLAMMATION 164 90.28 High High
Disease 51 89.92 High High
Chemotherapy-induced Neutropenia 2 86.64 High High
Pneumonia 15 77.76 Quite High
Pulmonary Fibrosis 56 71.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After protamine infusion, C3a levels reached 3,301 +/- 324 ng/ml, while the plasma lactoferrin levels declined to 522 +/- 57 ng/ml.
Negative_regulation (declined) of lactoferrin in plasma
1) Confidence 0.50 Published 1994 Journal ASAIO J. Section Abstract Doc Link 8186493 Disease Relevance 0 Pain Relevance 0.06
Furthermore, the potentiative effect of bLF was partially blocked by pre-treatment with N(G)-nitro-L-arginine methyl ester (L-NAME), a nonselective nitric oxide synthase (NOS) inhibitor, and completely blocked by 7-nitroindazole (7-NI), a selective neuronal NOS (nNOS) inhibitor.
Negative_regulation (blocked) of bLF in neuronal
2) Confidence 0.43 Published 2006 Journal Brain Res. Section Abstract Doc Link 16380099 Disease Relevance 0.07 Pain Relevance 1.28
Furthermore, the potentiative effect of bLF was partially blocked by pre-treatment with N(G)-nitro-L-arginine methyl ester (L-NAME), a nonselective nitric oxide synthase (NOS) inhibitor, and completely blocked by 7-nitroindazole (7-NI), a selective neuronal NOS (nNOS) inhibitor.
Negative_regulation (blocked) of bLF in neuronal
3) Confidence 0.43 Published 2006 Journal Brain Res. Section Abstract Doc Link 16380099 Disease Relevance 0.07 Pain Relevance 1.38
One possible explanation for the elimination of these expulsive processes is that the blockade of the LTF neurons may remove an important source of a facilitatory input to the brainstem circuitries that mediate cough and expiration reflexes.
Negative_regulation (blockade) of LTF in brainstem associated with medulla and cough
4) Confidence 0.42 Published 2000 Journal Physiol Res Section Abstract Doc Link 11043927 Disease Relevance 0.39 Pain Relevance 0.15
and IL-6 levels via inhibition of TLR4 signalling [188, 189] and lactoferrin can protect from lethal E.coli injection [190].
Negative_regulation (inhibition) of lactoferrin
5) Confidence 0.13 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.63 Pain Relevance 0.14
as a key mediator in the stimulation of hepatocellular proliferation, recent findings suggest that down-regulation of the iron-binding protein lactoferrin (LF) upon PP treatment may play a role in initiating the growth response [90].
Negative_regulation (regulation) of lactoferrin
6) Confidence 0.11 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 0.20 Pain Relevance 0.12
Indeed, IPF patients have higher numbers of neutrophils and higher concentrations of granule enzymes, such as neutrophil elastase, myeloperoxydase, collagenase and lactoferrin in BALF, plasma and lung tissue [30,31].
Negative_regulation (numbers) of lactoferrin in plasma
7) Confidence 0.09 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 1.23 Pain Relevance 0.44
Indeed, IPF patients have higher numbers of neutrophils and higher concentrations of granule enzymes, such as neutrophil elastase, myeloperoxydase, collagenase and lactoferrin in BALF, plasma and lung tissue [30,31].
Negative_regulation (numbers) of lactoferrin in lung
8) Confidence 0.03 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 1.23 Pain Relevance 0.44
Hasmall et al. (2002) reported a 3- to 7-fold down-regulation of lactoferrin mRNA in response to DEHP in wild-type versus PPAR?
Negative_regulation (regulation) of lactoferrin mRNA
9) Confidence 0.03 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.38 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox