INT57526

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Context Info
Confidence 0.45
First Reported 1994
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.73
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ltf) transport (Ltf) extracellular region (Ltf)
cytoplasm (Ltf)
Anatomy Link Frequency
tear 1
brain 1
Ltf (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 4 100.00 Very High Very High Very High
Inflammation 12 86.00 High High
cytokine 14 84.96 Quite High
nud 4 69.28 Quite High
cINOD 5 66.16 Quite High
hypoalgesia 2 50.00 Quite Low
Angina 1 50.00 Quite Low
agonist 34 28.96 Quite Low
Bile 4 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorders Of The Lacrimal System 3 98.40 Very High Very High Very High
Dry Eye 2 97.48 Very High Very High Very High
Targeted Disruption 42 96.24 Very High Very High Very High
Stress 7 94.52 High High
Infection 5 93.92 High High
Syndrome 1 93.64 High High
Toxicity 18 92.24 High High
Iron-deficiency Anemia 1 86.24 High High
INFLAMMATION 14 86.00 High High
Idiopathic Thrombocytopenic Purpura 1 84.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined also the possible additional beneficial effect of some novel non antibiotic agents such as lactoferrin, probiotics and natural substances.
Spec (possible) Regulation (effect) of lactoferrin
1) Confidence 0.45 Published 2007 Journal Recent patents on anti-infective drug discovery Section Abstract Doc Link 18221177 Disease Relevance 0.82 Pain Relevance 0.10
Since no significant interaction was found, the effect of alphaLF and LF/HF ratio on pain perception was assumed to be similar in normotensive and hypertensive subjects.
Regulation (effect) of alphaLF
2) Confidence 0.28 Published 2002 Journal Auton Neurosci Section Body Doc Link 12241087 Disease Relevance 0 Pain Relevance 0
In individual patients, however, the changes in lactoferrin during bypass did not correlate with changes in C3a levels (r = -0.06).
Regulation (changes) of lactoferrin
3) Confidence 0.26 Published 1994 Journal ASAIO J. Section Abstract Doc Link 8186493 Disease Relevance 0 Pain Relevance 0.07
CONCLUSIONS: Fecal lactoferrin is sensitive and specific for detecting inflammation in chronic IBD.
Regulation (sensitive) of lactoferrin
4) Confidence 0.23 Published 2003 Journal Am. J. Gastroenterol. Section Body Doc Link 12818275 Disease Relevance 0.18 Pain Relevance 0
The aim of this study was to compare the influence of topical anesthesia on the mean values of Schirmer's test, tear lysozyme, tear lactoferrin, and tear osmolarity in patients suffering from blepharitis-associated dry eye syndrome.
Regulation (influence) of lactoferrin in tear associated with disorders of the lacrimal system, anesthesia and dry eye
5) Confidence 0.21 Published 1997 Journal Ocul. Immunol. Inflamm. Section Abstract Doc Link 9145691 Disease Relevance 0.53 Pain Relevance 0.27
Both were transported into the brain at significantly higher levels (approximately 10 fold higher) than lactoferrin control [48].
Regulation (control) of lactoferrin in brain
6) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.47 Pain Relevance 0
as a key mediator in the stimulation of hepatocellular proliferation, recent findings suggest that down-regulation of the iron-binding protein lactoferrin (LF) upon PP treatment may play a role in initiating the growth response [90].
Regulation (regulation) of lactoferrin
7) Confidence 0.11 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 0.20 Pain Relevance 0.12
RESULTS: Myeloperoxydase, lactoferrin and elastase levels remained unchanged following catheterization, whereas a significant increase in myeloperoxydase (P = 0.0009) and lactoferrin (P = 0.004) was observed after stenting.
Neg (unchanged) Regulation (unchanged) of lactoferrin
8) Confidence 0.07 Published 2005 Journal Coron. Artery Dis. Section Body Doc Link 15654202 Disease Relevance 0.08 Pain Relevance 0
Hasmall et al. (2002) reported a 3- to 7-fold down-regulation of lactoferrin mRNA in response to DEHP in wild-type versus PPAR?
Regulation (regulation) of lactoferrin mRNA
9) Confidence 0.03 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 0.38 Pain Relevance 0

General Comments

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