INT57555

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Context Info
Confidence 0.06
First Reported 1994
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.05
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1, Oprl1) plasma membrane (Oprl1)
Oprm1 (Rattus norvegicus)
Oprl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 6 100.00 Very High Very High Very High
Opioid 3 100.00 Very High Very High Very High
Delta opioid receptors 1 99.56 Very High Very High Very High
narcan 3 99.42 Very High Very High Very High
Thalamus 3 97.84 Very High Very High Very High
medulla 1 85.20 High High
Hippocampus 2 83.20 Quite High
midbrain 1 81.92 Quite High
cerebral cortex 1 79.68 Quite High
Nucleus accumbens 1 56.48 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1 52.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The deduced amino-acid sequence of rat mu-opioid receptor consists of 398 residues with the features shared by the members of the G-protein coupled receptor family, and is 59% and 60% identical with those of rat kappa-opioid and mouse delta-opioid receptors, respectively.
mu-opioid receptor Binding (those) of kappa-opioid associated with delta opioid receptors, opioid receptor and opioid
1) Confidence 0.06 Published 1994 Journal Neurosci. Res. Section Abstract Doc Link 8190373 Disease Relevance 0.05 Pain Relevance 0.65
Although naloxone benzoylhydrazone has higher affinity for the MOR-1/KOR-3 chimera in binding studies than KOR-3 itself, it is inactive in cyclase studies using the MOR-1/KOR-3 chimera, implying that the replacement of the first coding exon increases affinity while decreasing intrinsic activity.
MOR-1 Binding (affinity) of KOR-3 associated with narcan
2) Confidence 0.01 Published 1996 Journal FEBS Lett. Section Abstract Doc Link 8898097 Disease Relevance 0 Pain Relevance 0.32

General Comments

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