INT5756

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Context Info
Confidence 0.59
First Reported 1992
Last Reported 2004
Negated 2
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.07
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNN1)
Anatomy Link Frequency
peripheral nerves 2
neuronal 1
skeletal muscle 1
brain 1
oocytes 1
KCNN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 10 98.44 Very High Very High Very High
Action potential 2 98.28 Very High Very High Very High
sodium channel 21 98.04 Very High Very High Very High
Pain 4 93.48 High High
Potency 2 92.84 High High
potassium channel 7 88.24 High High
conotoxin 1 85.40 High High
Inflammation 2 58.00 Quite High
Nerve growth factor 8 25.00 Low Low
neurotrophin 3 6 25.00 Low Low
Disease Link Frequency Relevance Heat
Nervous System Injury 4 94.40 High High
Pain 4 93.48 High High
Myotonic Disorders 3 82.40 Quite High
Hyperkalemic Periodic Paralysis 3 81.32 Quite High
INFLAMMATION 2 58.00 Quite High
Injury 6 54.00 Quite High
Salivary Gland Disease 1 51.68 Quite High
Wallerian Degeneration 2 25.00 Low Low
Paralysis 3 5.00 Very Low Very Low Very Low
Functional Bowel Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SK1 mRNA was detected almost exclusively in neuronal tissues.
Gene_expression (detected) of SK1 mRNA in neuronal
1) Confidence 0.59 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15127180 Disease Relevance 0.11 Pain Relevance 0.07
We studied the presence and changes of human SK1 (hSK1)- and hIK1-like immunoreactivity in control and injured human dorsal root ganglia (DRG) and peripheral nerves and their regulation by key neurotrophic factors in cultured rat sensory neurones.
Gene_expression (presence) of SK1 in peripheral nerves
2) Confidence 0.15 Published 2002 Journal Brain Section Abstract Doc Link 11844726 Disease Relevance 0.24 Pain Relevance 0.18
We studied the presence and changes of human SK1 (hSK1)- and hIK1-like immunoreactivity in control and injured human dorsal root ganglia (DRG) and peripheral nerves and their regulation by key neurotrophic factors in cultured rat sensory neurones.
Gene_expression (presence) of hSK1 in peripheral nerves
3) Confidence 0.15 Published 2002 Journal Brain Section Abstract Doc Link 11844726 Disease Relevance 0.24 Pain Relevance 0.18
Specific hSkM1 RNA transcripts are expressed in adult human skeletal muscle but not in heart, brain, or uterus.
Neg (not) Gene_expression (expressed) of hSkM1 in heart
4) Confidence 0.00 Published 1992 Journal Ann. Neurol. Section Abstract Doc Link 1315496 Disease Relevance 0.16 Pain Relevance 0.44
The SCN4A gene product, hSkM1, is the human homologue of rSkM1, the tetrodotoxin-sensitive sodium channel characteristic of adult rat skeletal muscle.
Gene_expression (product) of hSkM1 in skeletal muscle associated with tetrodotoxin and sodium channel
5) Confidence 0.00 Published 1992 Journal Ann. Neurol. Section Abstract Doc Link 1315496 Disease Relevance 0.15 Pain Relevance 0.44
Single-channel recordings were obtained from outside-out patches of oocytes expressing hSkM1.
Gene_expression (expressing) of hSkM1 in oocytes
6) Confidence 0.00 Published 1994 Journal Pflugers Arch. Section Abstract Doc Link 8058462 Disease Relevance 0 Pain Relevance 0.52
Specific hSkM1 RNA transcripts are expressed in adult human skeletal muscle but not in heart, brain, or uterus.
Neg (not) Gene_expression (expressed) of hSkM1 in brain
7) Confidence 0.00 Published 1992 Journal Ann. Neurol. Section Abstract Doc Link 1315496 Disease Relevance 0.16 Pain Relevance 0.44

General Comments

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